Beta-arrestin-2 - FZD1 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD1 72.8
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 A 439 4x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 A 439 4x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM4 G 436 4x34 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 Y 350 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 T 525 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 525 - S6 D 79 N.S6.04
Hydrophobic TM2 P 351 2x40 s5s6 L 72 N.s5s6.08
Hydrophobic N-term Q 152 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term Q 152 - s11s12 L 192 C.s11s12.02
Hydrophobic TM4 G 436 4x34 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 I 516 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 I 516 5x72 S6 F 76 N.S6.01
Hydrophobic TM5 I 516 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 L 533 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 533 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic N-term P 210 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term P 210 - s11s12 M 193 C.s11s12.03
Hydrophobic ICL2 W 435 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 W 435 - s8s9 K 139 N.s8s9.09
Hydrophobic TM3 W 427 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 W 435 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 W 435 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 W 435 - s8s9 T 137 N.s8s9.07
Hydrophobic TM5 M 520 5x76 S6 F 76 N.S6.01
Hydrophobic TM6 I 537 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 434 - s15s16 S 246 C.s15s16.04
Hydrophobic TM6 L 530 6x26 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 530 6x26 s5s6 L 74 N.s5s6.10
Polar ICL2 K 434 - S5 Y 64 N.S5.12
Hydrophobic ICL2 K 434 - S5 Y 64 N.S5.12
Van-der-waals ICL2 K 434 - S5 Y 64 N.S5.12
Hydrophobic TM3 A 430 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 513 5x69 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 M 520 5x76 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 520 5x76 s15s16 F 245 C.s15s16.03
Polar ICL2 K 434 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 K 434 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 K 434 - s15s16 F 245 C.s15s16.03
Hydrophobic TM4 H 437 4x35 s5s6 L 69 N.s5s6.05
Van-der-waals TM4 H 437 4x35 s5s6 L 69 N.s5s6.05
Polar ICL3 T 525 - S6 R 77 N.S6.02
Hydrophobic ICL3 T 525 - S6 R 77 N.S6.02
Hydrophobic TM4 H 437 4x35 s5s6 V 71 N.s5s6.07
Ionic TM4 E 438 4x36 s5s6 R 66 N.s5s6.02
Polar TM4 E 438 4x36 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 E 438 4x36 s5s6 R 66 N.s5s6.02
Van-der-waals TM4 E 438 4x36 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 P 351 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 351 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM5 M 520 5x76 S6 R 77 N.S6.02
Polar ICL2 K 434 - s8s9 K 139 N.s8s9.09
Hydrophobic TM4 G 436 4x34 s8s9 K 139 N.s8s9.09
Van-der-waals TM4 G 436 4x34 s8s9 K 139 N.s8s9.09
Polar N-term G 206 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term G 206 - s18s19 R 332 C.s18s19.02
Van-der-waals N-term G 206 - s18s19 R 332 C.s18s19.02
Polar TM5 I 519 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 I 519 5x75 S6 K 78 N.S6.03
Ionic N-term R 49 - s8s9 E 135 N.s8s9.05
Polar N-term R 49 - s8s9 E 135 N.s8s9.05
Hydrophobic N-term R 49 - s8s9 E 135 N.s8s9.05
Van-der-waals N-term R 49 - s8s9 E 135 N.s8s9.05
Polar TM4 G 436 4x34 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 G 436 4x34 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 I 519 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 I 519 5x75 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 T 525 - S6 K 78 N.S6.03
Hydrophobic TM6 L 533 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 533 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic N-term T 212 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term T 212 - s11s12 M 193 C.s11s12.03
Ionic TM5 D 523 5x79 S6 K 78 N.S6.03
Polar TM5 D 523 5x79 S6 K 78 N.S6.03
Hydrophobic TM5 D 523 5x79 S6 K 78 N.S6.03
Van-der-waals TM5 D 523 5x79 S6 K 78 N.S6.03