Beta-arrestin-1 - FZD2 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
FZD2 79.9
Beta-arrestin-1 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 W 360 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 W 360 - s8s9 K 138 N.s8s9.09
Hydrophobic TM6 L 458 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 458 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 K 359 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 K 359 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 359 - s15s16 N 245 C.s15s16.04
Hydrophobic TM4 G 361 4x34 s8s9 K 138 N.s8s9.09
Van-der-waals TM4 G 361 4x34 s8s9 K 138 N.s8s9.09
Polar ICL2 K 359 - S5 Y 63 N.S5.12
Hydrophobic ICL2 K 359 - S5 Y 63 N.S5.12
Van-der-waals ICL2 K 359 - S5 Y 63 N.S5.12
Hydrophobic TM2 P 276 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 P 276 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 462 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 W 352 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 M 358 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 M 358 - s15s16 N 245 C.s15s16.04
Hydrophobic TM7 W 538 7x55 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 355 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic N-term F 130 - s18s19 G 333 C.s18s19.04
Hydrophobic ICL1 R 274 12x51 s5s6 L 68 N.s5s6.05
Van-der-waals ICL1 R 274 12x51 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 P 276 2x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 454 6x25 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 454 6x25 s5s6 L 73 N.s5s6.10
Hydrophobic N-term E 72 - s11s12 L 191 C.s11s12.02
Van-der-waals N-term E 72 - s11s12 L 191 C.s11s12.02
Hydrophobic TM6 L 455 6x26 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 455 6x26 s5s6 L 73 N.s5s6.10
Polar N-term R 135 - S11 Q 189 C.S11.06
Hydrophobic TM5 M 445 5x76 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 M 445 5x76 s15s16 F 244 C.s15s16.03
Hydrophobic TM4 H 362 4x35 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 444 5x75 s15s16 F 244 C.s15s16.03
Ionic TM4 E 363 4x36 s5s6 R 65 N.s5s6.02
Polar TM4 E 363 4x36 s5s6 R 65 N.s5s6.02
Hydrophobic TM4 E 363 4x36 s5s6 R 65 N.s5s6.02
Van-der-waals TM4 E 363 4x36 s5s6 R 65 N.s5s6.02
Polar N-term Q 75 - s18s19 R 331 C.s18s19.02
Hydrophobic N-term Q 75 - s18s19 R 331 C.s18s19.02
Van-der-waals N-term Q 75 - s18s19 R 331 C.s18s19.02
Hydrophobic TM5 M 445 5x76 S6 F 75 N.S6.01
Hydrophobic TM5 I 441 5x72 s15s16 F 244 C.s15s16.03
Ionic ICL3 D 448 - S6 K 77 N.S6.03
Polar ICL3 D 448 - S6 K 77 N.S6.03
Hydrophobic ICL3 D 448 - S6 K 77 N.S6.03
Van-der-waals ICL3 D 448 - S6 K 77 N.S6.03
Hydrophobic ICL3 D 448 - S6 D 78 N.S6.04
Van-der-waals ICL3 D 448 - S6 D 78 N.S6.04
Hydrophobic ICL3 T 450 - S6 D 78 N.S6.04
Hydrophobic ICL2 K 359 - s8s9 K 138 N.s8s9.09
Hydrophobic TM5 I 444 5x75 S6 K 77 N.S6.03
Hydrophobic N-term Q 75 - s11s12 L 191 C.s11s12.02
Van-der-waals N-term Q 75 - s11s12 L 191 C.s11s12.02
Polar ICL3 T 450 - S6 R 76 N.S6.02
Hydrophobic ICL3 T 450 - S6 R 76 N.S6.02
Hydrophobic N-term F 130 - s11s12 M 192 C.s11s12.03
Hydrophobic ICL3 T 450 - S6 K 77 N.S6.03
Hydrophobic TM2 E 277 2x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 444 5x75 s15s16 L 243 C.s15s16.02
Hydrophobic TM6 L 458 6x29 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 458 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 A 364 4x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 A 364 4x37 s8s9 T 136 N.s8s9.07
Polar TM4 G 361 4x34 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 G 361 4x34 s8s9 T 136 N.s8s9.07
Polar ICL2 W 360 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 W 360 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 W 360 - s8s9 T 136 N.s8s9.07
Hydrophobic N-term F 76 - s11s12 L 191 C.s11s12.02
Hydrophobic TM4 H 362 4x35 s5s6 L 68 N.s5s6.05
Van-der-waals TM4 H 362 4x35 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 441 5x72 S6 F 75 N.S6.01
Van-der-waals TM5 I 441 5x72 S6 F 75 N.S6.01