Beta-arrestin-2 - FZD3 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD3 68.5
Beta-arrestin-2 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 317 - s15s16 S 246 C.s15s16.04
Hydrophobic TM6 K 413 6x25 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 413 6x25 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 397 5x69 s5s6 L 72 N.s5s6.08
Ionic TM4 K 326 4x40 s8s9 E 135 N.s8s9.05
Polar TM4 K 326 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 326 4x40 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 326 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 404 5x76 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 404 5x76 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 N 410 6x22 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 N 410 6x22 s5s6 L 74 N.s5s6.10
Ionic C-term E 529 - s20c K 400 C.s20c.10
Polar C-term E 529 - s20c K 400 C.s20c.10
Hydrophobic C-term E 529 - s20c K 400 C.s20c.10
Van-der-waals C-term E 529 - s20c K 400 C.s20c.10
Hydrophobic TM6 F 417 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 417 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 318 - s15s16 S 246 C.s15s16.04
Polar ICL2 K 318 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 K 318 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 K 318 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term L 527 - s20c K 400 C.s20c.10
Van-der-waals C-term L 527 - s20c K 400 C.s20c.10
Polar TM4 K 326 4x40 s8s9 P 134 N.s8s9.04
Hydrophobic TM4 K 326 4x40 s8s9 P 134 N.s8s9.04
Van-der-waals TM4 K 326 4x40 s8s9 P 134 N.s8s9.04
Hydrophobic TM4 G 320 4x34 s5s6 V 71 N.s5s6.07
Ionic ICL1 R 232 12x51 s5s6 D 70 N.s5s6.06
Polar ICL1 R 232 12x51 s5s6 D 70 N.s5s6.06
Van-der-waals ICL1 R 232 12x51 s5s6 D 70 N.s5s6.06
Ionic ICL3 E 407 - S6 R 77 N.S6.02
Polar ICL3 E 407 - S6 R 77 N.S6.02
Hydrophobic ICL3 E 407 - S6 R 77 N.S6.02
Polar TM6 N 410 6x22 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 N 410 6x22 s5s6 S 75 N.s5s6.11
Hydrophobic ICL3 L 406 - S6 F 76 N.S6.01
Hydrophobic C-term Q 528 - s20c K 400 C.s20c.10
Hydrophobic TM2 P 234 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 234 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 414 6x26 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 414 6x26 s5s6 L 74 N.s5s6.10
Hydrophobic TM4 A 323 4x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 A 323 4x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM4 G 320 4x34 s8s9 K 139 N.s8s9.09
Van-der-waals TM4 G 320 4x34 s8s9 K 139 N.s8s9.09
Polar ICL2 K 318 - S5 Y 64 N.S5.12
Polar ICL2 W 319 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 W 319 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 W 319 - s8s9 K 139 N.s8s9.09
Hydrophobic TM5 V 400 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 V 400 5x72 S6 F 76 N.S6.01
Polar TM4 G 320 4x34 s8s9 T 137 N.s8s9.07
Van-der-waals TM4 G 320 4x34 s8s9 T 137 N.s8s9.07
Hydrophobic TM4 S 321 4x35 s5s6 V 71 N.s5s6.07
Polar ICL2 W 319 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 W 319 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 W 319 - s8s9 T 137 N.s8s9.07
Ionic TM4 E 322 4x36 s5s6 R 66 N.s5s6.02
Polar TM4 E 322 4x36 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 K 318 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 K 318 - s8s9 K 139 N.s8s9.09
Hydrophobic TM3 A 314 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 A 314 3x53 s5s6 V 71 N.s5s6.07