Beta-arrestin-2 - FZD5 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD5 76.2
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic N-term P 128 - s11s12 L 192 C.s11s12.02
Polar TM4 N 350 4x35 s5s6 V 71 N.s5s6.07
Hydrophobic TM4 N 350 4x35 s5s6 V 71 N.s5s6.07
Van-der-waals TM4 N 350 4x35 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 433 5x76 S6 F 76 N.S6.01
Hydrophobic TM5 I 433 5x76 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 433 5x76 s15s16 F 245 C.s15s16.03
Hydrophobic N-term L 73 - s11s12 L 192 C.s11s12.02
Polar ICL3 T 438 - S6 R 77 N.S6.02
Van-der-waals ICL3 T 438 - S6 R 77 N.S6.02
Hydrophobic TM2 P 267 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 P 267 2x40 s5s6 V 71 N.s5s6.07
Polar ICL2 W 348 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 W 348 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 W 348 - s8s9 T 137 N.s8s9.07
Hydrophobic N-term F 125 - s11s12 S 194 C.s11s12.04
Van-der-waals N-term F 125 - s11s12 S 194 C.s11s12.04
Hydrophobic TM5 I 429 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic N-term E 66 - s18s19 G 334 C.s18s19.04
Van-der-waals N-term E 66 - s18s19 G 334 C.s18s19.04
Ionic N-term D 58 - S15 R 237 C.S15.09
Polar N-term D 58 - S15 R 237 C.S15.09
Hydrophobic N-term F 70 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term F 70 - s11s12 L 192 C.s11s12.02
Hydrophobic TM5 L 426 5x69 s5s6 L 72 N.s5s6.08
Hydrophobic N-term F 125 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term F 125 - s11s12 L 192 C.s11s12.02
Hydrophobic TM4 E 351 4x36 s5s6 L 69 N.s5s6.05
Van-der-waals TM4 E 351 4x36 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 A 343 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 344 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 G 349 4x34 s8s9 K 139 N.s8s9.09
Van-der-waals TM4 G 349 4x34 s8s9 K 139 N.s8s9.09
Hydrophobic N-term L 65 - S15 K 230 C.S15.02
Hydrophobic N-term F 125 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term F 125 - s11s12 M 193 C.s11s12.03
Hydrophobic N-term F 125 - s11s12 F 191 C.s11s12.01
Van-der-waals N-term F 125 - s11s12 F 191 C.s11s12.01
Polar N-term E 66 - S19 D 335 C.S19.02
Hydrophobic N-term M 120 - s11s12 L 192 C.s11s12.02
Van-der-waals N-term M 120 - s11s12 L 192 C.s11s12.02
Hydrophobic ICL3 G 436 - S6 K 78 N.S6.03
Polar N-term N 56 - S18 K 327 C.S18.10
Van-der-waals N-term N 56 - S18 K 327 C.S18.10
Ionic TM4 E 351 4x36 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 W 340 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 A 352 4x37 s8s9 T 137 N.s8s9.07
Polar ICL3 G 436 - S6 D 79 N.S6.04
Hydrophobic ICL3 G 436 - S6 D 79 N.S6.04
Van-der-waals ICL3 G 436 - S6 D 79 N.S6.04
Polar N-term L 65 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term L 65 - s18s19 R 332 C.s18s19.02
Van-der-waals N-term L 65 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term E 66 - s18s19 G 333 C.s18s19.03
Hydrophobic TM6 I 450 6x33 s5s6 L 72 N.s5s6.08
Ionic N-term D 58 - S18 K 327 C.S18.10
Polar N-term D 58 - S18 K 327 C.S18.10
Van-der-waals N-term D 58 - S18 K 327 C.S18.10
Hydrophobic TM5 V 432 5x75 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 432 5x75 s15s16 F 245 C.s15s16.03
Polar TM4 N 350 4x35 s5s6 D 70 N.s5s6.06
Hydrophobic TM4 N 350 4x35 s5s6 D 70 N.s5s6.06
Van-der-waals TM4 N 350 4x35 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 K 442 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 K 442 - s5s6 L 74 N.s5s6.10
Ionic TM5 R 428 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 R 428 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 L 443 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 L 443 - s5s6 L 74 N.s5s6.10
Hydrophobic N-term L 73 - s11s12 M 193 C.s11s12.03
Hydrophobic TM5 V 432 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 V 432 5x75 S6 K 78 N.S6.03
Hydrophobic N-term E 62 - S19 D 335 C.S19.02
Hydrophobic TM5 V 432 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 W 348 - s8s9 K 139 N.s8s9.09
Ionic N-term E 62 - S18 K 327 C.S18.10
Polar N-term E 62 - S18 K 327 C.S18.10
Hydrophobic N-term E 62 - S18 K 327 C.S18.10
Van-der-waals N-term E 62 - S18 K 327 C.S18.10
Polar TM3 K 347 3x57 S5 Y 64 N.S5.12
Hydrophobic TM3 K 347 3x57 S5 Y 64 N.S5.12
Van-der-waals TM3 K 347 3x57 S5 Y 64 N.S5.12
Hydrophobic TM3 A 343 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 A 343 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 446 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 446 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic N-term E 62 - S18 V 329 C.S18.12
Hydrophobic N-term K 29 - s8s9 E 135 N.s8s9.05
Van-der-waals N-term K 29 - s8s9 E 135 N.s8s9.05
Hydrophobic N-term L 65 - s18s19 S 331 C.s18s19.01
Hydrophobic TM2 P 267 2x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 P 267 2x40 s5s6 L 72 N.s5s6.08
Hydrophobic N-term Q 69 - s11s12 F 191 C.s11s12.01
Van-der-waals N-term Q 69 - s11s12 F 191 C.s11s12.01
Ionic N-term E 66 - S11 R 189 C.S11.05
Polar N-term E 66 - S11 R 189 C.S11.05
Van-der-waals N-term E 66 - S11 R 189 C.S11.05
Polar TM4 G 349 4x34 s8s9 T 137 N.s8s9.07
Polar N-term R 130 - S19 D 335 C.S19.02
Van-der-waals N-term R 130 - S19 D 335 C.S19.02
Polar N-term A 30 - s8s9 E 135 N.s8s9.05
Hydrophobic N-term A 30 - s8s9 E 135 N.s8s9.05
Van-der-waals N-term A 30 - s8s9 E 135 N.s8s9.05
Hydrophobic TM6 L 446 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 446 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic N-term R 130 - S11 R 189 C.S11.05
Van-der-waals N-term R 130 - S11 R 189 C.S11.05
Polar N-term Q 69 - s18s19 G 333 C.s18s19.03
Hydrophobic N-term Q 69 - s18s19 G 333 C.s18s19.03
Van-der-waals N-term Q 69 - s18s19 G 333 C.s18s19.03
Ionic N-term H 57 - S19 D 335 C.S19.02
Polar N-term H 57 - S19 D 335 C.S19.02
Hydrophobic N-term H 57 - S19 D 335 C.S19.02
Van-der-waals N-term H 57 - S19 D 335 C.S19.02
Hydrophobic N-term Y 123 - s11s12 M 193 C.s11s12.03
Van-der-waals N-term Y 123 - s11s12 M 193 C.s11s12.03
Hydrophobic N-term L 65 - S18 V 329 C.S18.12
Van-der-waals N-term L 65 - S18 V 329 C.S18.12
Polar N-term L 65 - s18s19 G 334 C.s18s19.04
Hydrophobic N-term L 65 - s18s19 G 334 C.s18s19.04
Polar N-term Q 69 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term Q 69 - s18s19 R 332 C.s18s19.02
Van-der-waals N-term Q 69 - s18s19 R 332 C.s18s19.02
Aromatic N-term H 68 - s18s19 R 332 C.s18s19.02
Hydrophobic N-term H 68 - s18s19 R 332 C.s18s19.02
Ionic N-term E 62 - S15 K 233 C.S15.05
Polar N-term E 62 - S15 K 233 C.S15.05
Hydrophobic N-term E 62 - S15 K 233 C.S15.05
Van-der-waals N-term E 62 - S15 K 233 C.S15.05
Polar TM4 N 350 4x35 s8s9 K 139 N.s8s9.09
Polar N-term L 65 - s18s19 G 333 C.s18s19.03
Van-der-waals N-term L 65 - s18s19 G 333 C.s18s19.03
Hydrophobic TM5 I 429 5x72 S6 F 76 N.S6.01
Van-der-waals TM5 I 429 5x72 S6 F 76 N.S6.01
Hydrophobic ICL3 T 438 - S6 D 79 N.S6.04
Van-der-waals ICL3 T 438 - S6 D 79 N.S6.04
Polar TM3 K 347 3x57 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 K 347 3x57 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 K 347 3x57 s15s16 F 245 C.s15s16.03
Polar N-term Q 69 - s11s12 L 192 C.s11s12.02
Hydrophobic TM3 K 347 3x57 s15s16 S 246 C.s15s16.04
Hydrophobic N-term L 65 - S18 V 330 C.S18.13
Van-der-waals N-term L 65 - S18 V 330 C.S18.13