Beta-arrestin-1 - FZD6 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FZD6 63.8
Beta-arrestin-1 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 20.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 314 - s15s16 N 245 C.s15s16.04
Hydrophobic TM5 I 400 5x76 S6 F 75 N.S6.01
Hydrophobic TM4 A 319 4x37 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 F 413 6x29 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 K 409 6x25 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 410 6x26 s5s6 L 71 N.s5s6.08
Polar ICL2 K 314 - s15s16 F 244 C.s15s16.03
Aromatic ICL2 K 314 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 K 314 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 K 314 - s15s16 F 244 C.s15s16.03
Polar TM2 R 228 2x38 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 228 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM4 S 316 4x34 s8s9 K 138 N.s8s9.09
Polar TM4 Q 322 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 Q 322 4x40 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 Q 322 4x40 s8s9 E 134 N.s8s9.05
Polar TM6 K 409 6x25 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 409 6x25 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 409 6x25 s5s6 G 72 N.s5s6.09
Ionic TM6 K 409 6x25 s5s6 E 66 N.s5s6.03
Polar TM6 K 409 6x25 s5s6 E 66 N.s5s6.03
Van-der-waals TM6 K 409 6x25 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 A 310 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 A 310 3x53 s5s6 V 70 N.s5s6.07
Polar TM4 C 317 4x35 s5s6 L 68 N.s5s6.05
Hydrophobic TM4 C 317 4x35 s5s6 L 68 N.s5s6.05
Van-der-waals TM4 C 317 4x35 s5s6 L 68 N.s5s6.05
Hydrophobic TM4 A 319 4x37 s8s9 D 135 N.s8s9.06
Hydrophobic TM2 R 228 2x38 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 R 228 2x38 s5s6 L 68 N.s5s6.05
Polar TM4 A 319 4x37 s8s9 P 133 N.s8s9.04
Van-der-waals TM4 A 319 4x37 s8s9 P 133 N.s8s9.04
Hydrophobic TM6 L 410 6x26 s5s6 L 73 N.s5s6.10
Polar C-term T 560 - s17s18 E 296 C.s17s18.22
Polar TM4 S 316 4x34 s8s9 T 136 N.s8s9.07
Hydrophobic TM4 S 316 4x34 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 S 316 4x34 s8s9 T 136 N.s8s9.07
Polar ICL2 K 314 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 K 314 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 K 314 - s8s9 K 138 N.s8s9.09
Hydrophobic TM5 I 400 5x76 s15s16 F 244 C.s15s16.03
Polar TM4 S 316 4x34 s8s9 G 137 N.s8s9.08
Hydrophobic TM4 S 316 4x34 s8s9 G 137 N.s8s9.08
Van-der-waals TM4 S 316 4x34 s8s9 G 137 N.s8s9.08
Polar TM4 S 316 4x34 s8s9 D 135 N.s8s9.06
Van-der-waals TM4 S 316 4x34 s8s9 D 135 N.s8s9.06
Polar ICL2 W 315 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 W 315 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 W 315 - s8s9 K 138 N.s8s9.09
Polar TM6 N 406 6x22 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 N 406 6x22 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 N 406 6x22 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 N 406 6x22 s5s6 L 73 N.s5s6.10
Polar C-term T 560 - s20c K 397 C.s20c.07
Hydrophobic C-term T 560 - s20c K 397 C.s20c.07
Van-der-waals C-term T 560 - s20c K 397 C.s20c.07
Hydrophobic TM2 P 230 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 P 230 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic C-term M 558 - s20c Q 394 C.s20c.04
Polar TM4 Q 322 4x40 s8s9 P 133 N.s8s9.04
Hydrophobic TM4 Q 322 4x40 s8s9 P 133 N.s8s9.04
Van-der-waals TM4 Q 322 4x40 s8s9 P 133 N.s8s9.04
Hydrophobic TM4 E 318 4x36 s8s9 P 133 N.s8s9.04
Van-der-waals TM4 E 318 4x36 s8s9 P 133 N.s8s9.04
Hydrophobic TM5 L 393 5x69 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 393 5x69 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 A 319 4x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 A 319 4x37 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 W 315 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 W 315 - s8s9 T 136 N.s8s9.07
Hydrophobic TM6 F 413 6x29 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 413 6x29 s5s6 L 71 N.s5s6.08
Polar C-term T 562 - s20c K 397 C.s20c.07
Van-der-waals C-term T 562 - s20c K 397 C.s20c.07
Polar TM4 C 317 4x35 s5s6 V 70 N.s5s6.07
Hydrophobic TM4 C 317 4x35 s5s6 V 70 N.s5s6.07
Van-der-waals TM4 C 317 4x35 s5s6 V 70 N.s5s6.07