Beta-arrestin-2 - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR137 57.0
Beta-arrestin-2 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 Q 119 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Q 119 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 A 210 - S16 A 248 C.S16.01
Van-der-waals ICL3 A 210 - S16 A 248 C.S16.01
Van-der-waals ICL3 S 203 - s17s18 R 286 C.s17s18.11
Polar C-term D 330 - s15s16 S 246 C.s15s16.04
Hydrophobic C-term D 330 - s15s16 S 246 C.s15s16.04
Van-der-waals C-term D 330 - s15s16 S 246 C.s15s16.04
Hydrophobic TM2 Q 59 2x43 s5s6 L 74 N.s5s6.10
Van-der-waals TM2 Q 59 2x43 s5s6 L 74 N.s5s6.10
Polar ICL3 A 210 - S16 Q 249 C.S16.02
Hydrophobic ICL3 A 210 - S16 Q 249 C.S16.02
Van-der-waals ICL3 A 210 - S16 Q 249 C.S16.02
Ionic TM3 K 127 3x61 s5s6 D 68 N.s5s6.04
Polar TM3 K 127 3x61 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 127 3x61 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 127 3x61 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 Y 116 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 Y 116 3x50 s5s6 L 72 N.s5s6.08
Polar TM3 K 127 3x61 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 K 127 3x61 s8s9 T 137 N.s8s9.07
Van-der-waals TM3 K 127 3x61 s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 I 206 - s17s18 G 287 C.s17s18.12
Ionic ICL1 K 54 - s5s6 D 70 N.s5s6.06
Polar ICL1 K 54 - s5s6 D 70 N.s5s6.06
Van-der-waals ICL1 K 54 - s5s6 D 70 N.s5s6.06
Polar TM3 K 123 3x57 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 K 123 3x57 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 K 123 3x57 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 P 202 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL3 P 202 - s8s9 E 135 N.s8s9.05
Van-der-waals C-term G 332 - s15s16 T 247 C.s15s16.05
Polar TM2 Q 59 2x43 s5s6 L 72 N.s5s6.08
Polar ICL3 K 211 - S5 Y 64 N.S5.12
Aromatic ICL1 H 53 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 H 53 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL1 H 53 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 K 54 - s5s6 G 73 N.s5s6.09
Hydrophobic TM3 K 123 3x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 K 123 3x57 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 I 206 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL3 I 206 - s17s18 R 286 C.s17s18.11
Ionic TM3 R 128 3x62 s8s9 E 135 N.s8s9.05
Polar TM3 R 128 3x62 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 R 128 3x62 s8s9 E 135 N.s8s9.05
Van-der-waals TM3 R 128 3x62 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 A 210 - S16 Y 250 C.S16.03
Van-der-waals ICL3 A 210 - S16 Y 250 C.S16.03
Polar ICL1 K 54 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL1 K 54 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL1 K 54 - s5s6 S 75 N.s5s6.11
Polar ICL3 K 211 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 K 211 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL3 K 211 - s15s16 S 246 C.s15s16.04
Ionic TM3 K 127 3x61 s5s6 E 67 N.s5s6.03
Polar ICL3 S 203 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 S 203 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL3 S 203 - s8s9 D 136 N.s8s9.06
Hydrophobic TM3 K 123 3x57 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 123 3x57 s5s6 D 68 N.s5s6.04
Van-der-waals C-term D 330 - s5s6 L 74 N.s5s6.10
Hydrophobic C-term H 327 - s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 120 3x54 s5s6 D 68 N.s5s6.04
Polar TM2 Y 58 2x42 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 Y 58 2x42 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 Y 58 2x42 s5s6 L 72 N.s5s6.08
Polar ICL3 Y 207 - S5 Y 64 N.S5.12
Hydrophobic ICL3 Y 207 - S5 Y 64 N.S5.12
Van-der-waals ICL3 Y 207 - S5 Y 64 N.S5.12
Polar ICL3 P 202 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL3 P 202 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL3 P 202 - s17s18 R 286 C.s17s18.11
Hydrophobic ICL3 Y 207 - s5s6 L 69 N.s5s6.05
Van-der-waals ICL3 Y 207 - s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 I 206 - S16 Y 250 C.S16.03
Van-der-waals ICL3 I 206 - S16 Y 250 C.S16.03
Polar TM3 K 127 3x61 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 K 127 3x61 s8s9 E 135 N.s8s9.05
Van-der-waals TM3 K 127 3x61 s8s9 E 135 N.s8s9.05
Hydrophobic TM1 Y 51 1x60 S6 F 76 N.S6.01
Van-der-waals TM1 Y 51 1x60 S6 F 76 N.S6.01
Van-der-waals ICL3 Y 207 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 K 211 - S16 A 248 C.S16.01
Aromatic ICL1 H 53 - S6 F 76 N.S6.01
Hydrophobic ICL1 H 53 - S6 F 76 N.S6.01
Van-der-waals ICL1 H 53 - S6 F 76 N.S6.01
Hydrophobic TM2 S 57 2x41 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 Y 58 2x42 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 58 2x42 s5s6 V 71 N.s5s6.07
Polar ICL3 S 203 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 S 203 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL3 S 203 - s5s6 R 66 N.s5s6.02
Polar TM2 S 57 2x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 S 57 2x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 S 57 2x41 s5s6 L 72 N.s5s6.08