Arrestin-C - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR137 54.9
Arrestin-C 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 S 203 - s15s16 L 243 C.s15s16.05
Polar C-term S 338 - s20c S 376 C.s20c.09
Hydrophobic ICL3 E 209 - S6 F 71 N.S6.01
Hydrophobic ICL3 A 210 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 A 210 - s5s6 L 69 N.s5s6.10
Polar TM3 K 127 3x61 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 K 127 3x61 s15s16 L 243 C.s15s16.05
Van-der-waals TM3 K 127 3x61 s15s16 L 243 C.s15s16.05
Hydrophobic C-term W 335 - s5s6 G 60 N.s5s6.01
Ionic TM3 K 127 3x61 S15 D 237 C.S15.13
Polar TM3 K 127 3x61 S15 D 237 C.S15.13
Hydrophobic TM3 K 127 3x61 S15 D 237 C.S15.13
Van-der-waals TM3 K 127 3x61 S15 D 237 C.S15.13
Ionic TM3 R 128 3x62 s17s18 E 310 C.s17s18.39
Polar TM3 R 128 3x62 s17s18 E 310 C.s17s18.39
Van-der-waals TM3 R 128 3x62 s17s18 E 310 C.s17s18.39
Polar ICL1 K 54 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL1 K 54 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL1 K 54 - s8s9 E 131 N.s8s9.05
Ionic TM3 K 123 3x57 S16 D 244 C.S16.01
Polar TM3 K 123 3x57 S16 D 244 C.S16.01
Hydrophobic TM3 K 123 3x57 S16 D 244 C.S16.01
Van-der-waals TM3 K 123 3x57 S16 D 244 C.S16.01
Hydrophobic ICL3 A 210 - S6 F 71 N.S6.01
Van-der-waals ICL3 A 210 - S6 F 71 N.S6.01
Hydrophobic ICL3 A 210 - s5s6 L 64 N.s5s6.05
Polar C-term S 334 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term S 334 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term D 330 - s5s6 L 64 N.s5s6.05
Hydrophobic C-term W 335 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term W 335 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 I 206 - S6 K 73 N.S6.03
Hydrophobic TM2 L 63 2x47 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 L 63 2x47 s5s6 V 66 N.s5s6.07
Polar TM3 K 127 3x61 S16 D 244 C.S16.01
Van-der-waals TM3 K 127 3x61 S16 D 244 C.S16.01
Hydrophobic TM1 Q 44 1x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM1 Q 44 1x53 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 Q 59 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 Q 59 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 A 124 3x58 s15s16 L 243 C.s15s16.05
Van-der-waals TM3 A 124 3x58 s15s16 L 243 C.s15s16.05
Hydrophobic ICL3 A 210 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 A 210 - s15s16 Y 241 C.s15s16.03
Polar TM3 Y 116 3x50 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 Y 116 3x50 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 Y 116 3x50 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 K 211 - s5s6 L 64 N.s5s6.05
Van-der-waals ICL3 K 211 - s5s6 L 64 N.s5s6.05
Polar TM3 Y 116 3x50 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 Y 116 3x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 K 211 - s5s6 L 69 N.s5s6.10
Hydrophobic C-term W 335 - s8s9 P 136 N.s8s9.10
Van-der-waals C-term W 335 - s8s9 P 136 N.s8s9.10
Polar C-term S 338 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term S 338 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term S 338 - s17s18 K 291 C.s17s18.20
Polar TM3 K 127 3x61 S15 V 238 C.S15.14
Van-der-waals TM3 K 127 3x61 S15 V 238 C.S15.14
Polar ICL3 S 203 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 S 203 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 S 203 - s17s18 E 310 C.s17s18.39
Hydrophobic C-term H 327 - s5s6 I 67 N.s5s6.08
Van-der-waals C-term H 327 - s5s6 I 67 N.s5s6.08
Polar TM2 Q 59 2x43 s5s6 L 64 N.s5s6.05
Polar C-term C 333 - s5s6 T 70 N.s5s6.11
Hydrophobic C-term C 333 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term C 333 - s5s6 T 70 N.s5s6.11
Polar ICL3 P 202 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 P 202 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 P 202 - s17s18 E 310 C.s17s18.39
Ionic ICL1 H 53 - s5s6 E 65 N.s5s6.06
Polar ICL1 H 53 - s5s6 E 65 N.s5s6.06
Hydrophobic ICL1 H 53 - s5s6 E 65 N.s5s6.06
Van-der-waals ICL1 H 53 - s5s6 E 65 N.s5s6.06
Hydrophobic TM2 Q 59 2x43 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 Q 59 2x43 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 S 203 - s15s16 V 239 C.s15s16.01
Van-der-waals ICL3 S 203 - s15s16 V 239 C.s15s16.01
Polar ICL3 S 203 - s15s16 Y 241 C.s15s16.03
Polar ICL3 Y 207 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 Y 207 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL3 Y 207 - s5s6 R 61 N.s5s6.02
Hydrophobic C-term C 328 - s5s6 I 67 N.s5s6.08
Van-der-waals C-term C 328 - s5s6 I 67 N.s5s6.08
Hydrophobic TM1 V 48 1x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM1 V 48 1x57 s5s6 V 66 N.s5s6.07
Ionic C-term R 339 - s20c E 383 C.s20c.17
Polar C-term R 339 - s20c E 383 C.s20c.17
Hydrophobic C-term R 339 - s20c E 383 C.s20c.17
Van-der-waals C-term R 339 - s20c E 383 C.s20c.17
Ionic ICL1 K 54 - s8s9 D 132 N.s8s9.06
Polar ICL1 K 54 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL1 K 54 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL1 K 54 - s8s9 D 132 N.s8s9.06
Polar ICL1 H 53 - s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 H 53 - s5s6 V 66 N.s5s6.07
Polar TM2 S 57 2x41 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 57 2x41 s5s6 D 63 N.s5s6.04
Polar C-term D 330 - s5s6 G 68 N.s5s6.09
Hydrophobic C-term D 330 - s5s6 G 68 N.s5s6.09
Van-der-waals C-term D 330 - s5s6 G 68 N.s5s6.09
Ionic ICL3 E 209 - S6 K 73 N.S6.03
Polar ICL3 E 209 - S6 K 73 N.S6.03
Van-der-waals ICL3 E 209 - S6 K 73 N.S6.03
Hydrophobic ICL3 Y 207 - s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 Y 207 - s15s16 Y 241 C.s15s16.03
Polar C-term D 330 - s5s6 L 69 N.s5s6.10
Hydrophobic C-term D 330 - s5s6 L 69 N.s5s6.10
Van-der-waals C-term D 330 - s5s6 L 69 N.s5s6.10
Hydrophobic TM2 Q 59 2x43 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 Q 59 2x43 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 A 201 5x65 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 A 201 5x65 s17s18 E 310 C.s17s18.39
Hydrophobic C-term W 335 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term W 335 - s5s6 E 65 N.s5s6.06
Polar ICL3 I 206 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 I 206 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 I 206 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 I 206 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 I 206 - s15s16 L 240 C.s15s16.02
Hydrophobic C-term D 330 - s5s6 I 67 N.s5s6.08
Van-der-waals C-term D 330 - s5s6 I 67 N.s5s6.08
Hydrophobic TM3 K 123 3x57 s15s16 L 243 C.s15s16.05
Hydrophobic C-term V 414 - s9s10 T 154 N.s9s10.09
Ionic ICL1 K 54 - s5s6 D 62 N.s5s6.03
Polar ICL1 K 54 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 K 54 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 K 54 - s5s6 D 62 N.s5s6.03