Gi1 - GPR37L1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR37L1 61.0
Gαi1 89.1
Gβ1 91.2
Gγ2 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 29.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term S 471 - G.H3 W 258 G.H3.17
Van-der-waals C-term S 471 - G.H3 W 258 G.H3.17
Hydrophobic TM4 R 244 4x38 G.hns1 R 32 G.hns1.03
Polar ICL2 L 236 34x50 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL2 L 236 34x50 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL2 L 236 34x50 G.h3s5 D 261 G.h3s5.02
Hydrophobic C-term F 465 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 465 - G.H3 S 252 G.H3.11
Hydrophobic TM4 R 244 4x38 G.H5 L 353 G.H5.25
Van-der-waals TM4 R 244 4x38 G.H5 L 353 G.H5.25
Polar ICL1 Y 159 12x48 G.HN R 24 G.HN.48
Hydrophobic ICL1 Y 159 12x48 G.HN R 24 G.HN.48
Van-der-waals ICL1 Y 159 12x48 G.HN R 24 G.HN.48
Hydrophobic ICL2 L 236 34x50 G.H5 D 350 G.H5.22
Van-der-waals ICL2 L 236 34x50 G.H5 D 350 G.H5.22
Hydrophobic C-term P 480 - G.HN E 28 G.HN.52
Van-der-waals C-term P 480 - G.HN E 28 G.HN.52
Polar ICL2 P 237 34x51 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL2 P 237 34x51 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL2 P 237 34x51 G.h3s5 D 261 G.h3s5.02
Hydrophobic C-term F 465 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term F 465 - G.h2s4 F 215 G.h2s4.01
Ionic C-term E 470 - G.H3 K 257 G.H3.16
Polar C-term E 470 - G.H3 K 257 G.H3.16
Hydrophobic C-term P 468 - G.H3 W 258 G.H3.17
Van-der-waals C-term P 468 - G.H3 W 258 G.H3.17
Hydrophobic C-term T 479 - G.HN R 24 G.HN.48
Van-der-waals C-term T 479 - G.HN R 24 G.HN.48
Polar C-term P 480 - G.HN R 24 G.HN.48
Hydrophobic C-term P 480 - G.HN R 24 G.HN.48
Van-der-waals C-term P 480 - G.HN R 24 G.HN.48
Hydrophobic C-term F 465 - G.H2 I 212 G.H2.08
Hydrophobic C-term F 465 - G.H3 I 253 G.H3.12