Beta-arrestin-2 - GAL1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GAL1 79.9
Beta-arrestin-2 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 140 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 231 5x69 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 231 5x69 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 137 3x54 s5s6 L 72 N.s5s6.08
Polar TM6 S 235 6x23 S6 R 77 N.S6.02
Hydrophobic TM6 S 235 6x23 S6 R 77 N.S6.02
Van-der-waals TM6 S 235 6x23 S6 R 77 N.S6.02
Polar TM6 T 245 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 245 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 245 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 227 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 227 5x65 S6 F 76 N.S6.01
Hydrophobic ICL1 P 66 - s8s9 P 134 N.s8s9.04
Hydrophobic TM6 K 237 6x25 S6 R 77 N.S6.02
Polar TM6 T 245 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 A 136 3x53 s5s6 L 69 N.s5s6.05
Polar TM4 S 149 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 149 4x39 s8s9 E 135 N.s8s9.05
Polar TM2 T 70 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 70 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 70 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 L 227 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 231 5x69 S6 F 76 N.S6.01
Van-der-waals TM5 L 231 5x69 S6 F 76 N.S6.01
Polar TM6 S 238 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 S 238 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 S 238 6x26 S6 R 77 N.S6.02
Polar ICL2 S 140 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 S 140 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 S 140 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 137 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 137 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 R 141 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 R 141 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 R 141 34x51 s15s16 T 247 C.s15s16.05
Polar TM6 T 245 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 245 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 245 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 S 143 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 143 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 M 234 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 M 234 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 M 234 - S6 F 76 N.S6.01
Polar TM3 R 133 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 133 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 141 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 R 141 34x51 S16 A 248 C.S16.01
Ionic ICL1 K 65 - s20c D 402 C.s20c.12
Polar ICL1 K 65 - s20c D 402 C.s20c.12
Hydrophobic ICL1 K 65 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 65 - s20c D 402 C.s20c.12
Hydrophobic ICL3 M 234 - S6 R 77 N.S6.02
Van-der-waals ICL3 M 234 - S6 R 77 N.S6.02
Hydrophobic TM6 V 249 6x37 s5s6 L 72 N.s5s6.08
Polar TM6 S 241 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 S 241 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals C-term R 323 - s20c C 409 C.s20c.19
Ionic ICL1 K 62 - s20c D 402 C.s20c.12
Polar ICL1 K 62 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 62 - s20c D 402 C.s20c.12
Hydrophobic TM6 T 248 6x36 s5s6 L 72 N.s5s6.08
Polar ICL2 S 140 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 S 140 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 S 140 34x50 S5 Y 64 N.S5.12
Polar TM6 S 241 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 S 241 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 S 241 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 S 238 6x26 S6 F 76 N.S6.01
Polar H8 K 319 8x59 s20c C 409 C.s20c.19
Van-der-waals H8 K 319 8x59 s20c C 409 C.s20c.19
Hydrophobic TM6 S 235 6x23 S6 D 79 N.S6.04
Van-der-waals TM6 S 235 6x23 S6 D 79 N.S6.04
Hydrophobic TM2 T 70 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 70 2x39 s5s6 V 71 N.s5s6.07
Polar H8 S 307 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 307 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 K 62 - s20c Y 404 C.s20c.14
Polar H8 N 309 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 N 309 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 N 309 8x49 s5s6 E 67 N.s5s6.03
Ionic ICL2 R 147 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 147 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 147 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 147 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL3 N 233 - S6 K 78 N.S6.03
Hydrophobic TM3 I 137 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 137 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL1 P 66 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 P 66 - s8s9 E 135 N.s8s9.05
Hydrophobic TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 I 74 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 74 2x43 s5s6 V 71 N.s5s6.07
Polar ICL1 K 62 - s8s9 T 137 N.s8s9.07
Polar TM5 H 226 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 226 5x64 s15s16 F 245 C.s15s16.03
Polar H8 S 307 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 307 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 307 8x47 s5s6 D 70 N.s5s6.06
Polar ICL1 K 65 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 K 65 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 M 234 - S6 K 78 N.S6.03
Hydrophobic ICL2 S 144 34x54 s5s6 R 66 N.s5s6.02
Polar H8 E 308 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 E 308 8x48 s5s6 D 70 N.s5s6.06
Polar H8 N 309 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 N 309 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 309 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM7 Y 303 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 303 7x53 s5s6 V 71 N.s5s6.07