Arrestin-C - GAL1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GAL1 79.6
Arrestin-C 82.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM5 K 230 5x68 s17s18 E 310 C.s17s18.39
Polar TM5 K 230 5x68 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 K 230 5x68 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 K 230 5x68 s17s18 E 310 C.s17s18.39
Polar ICL3 N 233 - S6 K 73 N.S6.03
Hydrophobic ICL3 N 233 - S6 K 73 N.S6.03
Van-der-waals ICL3 N 233 - S6 K 73 N.S6.03
Polar C-term R 323 - s20c S 388 C.s20c.22
Hydrophobic C-term R 323 - s20c S 388 C.s20c.22
Van-der-waals C-term R 323 - s20c S 388 C.s20c.22
Polar TM6 S 241 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 S 241 6x29 s5s6 G 68 N.s5s6.09
Polar ICL2 S 143 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 143 34x53 s5s6 R 61 N.s5s6.02
Polar ICL2 S 144 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 S 144 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 S 144 34x54 s8s9 D 132 N.s8s9.06
Polar TM6 T 245 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 245 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 245 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 T 70 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 70 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 L 231 5x69 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 231 5x69 s15s16 Y 241 C.s15s16.03
Polar ICL2 S 140 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 S 140 34x50 S5 Y 59 N.S5.12
Ionic ICL2 R 141 34x51 S15 D 237 C.S15.13
Polar ICL2 R 141 34x51 S15 D 237 C.S15.13
Hydrophobic TM6 V 249 6x37 s5s6 I 67 N.s5s6.08
Polar H8 N 309 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 N 309 8x49 s5s6 D 62 N.s5s6.03
Ionic H8 K 312 8x52 s5s6 E 65 N.s5s6.06
Polar H8 K 312 8x52 s5s6 E 65 N.s5s6.06
Ionic ICL1 K 62 - s20c E 383 C.s20c.17
Polar ICL1 K 62 - s20c E 383 C.s20c.17
Polar C-term R 323 - s20c G 387 C.s20c.21
Hydrophobic C-term R 323 - s20c G 387 C.s20c.21
Van-der-waals C-term R 323 - s20c G 387 C.s20c.21
Polar ICL2 S 140 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 S 140 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 S 140 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 S 140 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 140 34x50 s5s6 R 61 N.s5s6.02
Polar ICL2 R 141 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 R 141 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 R 141 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic TM2 S 68 2x37 s5s6 D 63 N.s5s6.04
Polar TM6 S 238 6x26 S6 R 72 N.S6.02
Hydrophobic TM6 S 238 6x26 S6 R 72 N.S6.02
Van-der-waals TM6 S 238 6x26 S6 R 72 N.S6.02
Polar ICL2 S 140 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 S 140 34x50 s15s16 Y 241 C.s15s16.03
Ionic TM6 K 236 6x24 s9s10 E 152 N.s9s10.07
Polar TM6 K 236 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 236 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 236 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 M 234 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 M 234 - s15s16 Y 241 C.s15s16.03
Polar TM6 S 235 6x23 S6 D 74 N.S6.04
Hydrophobic TM6 S 235 6x23 S6 D 74 N.S6.04
Van-der-waals TM6 S 235 6x23 S6 D 74 N.S6.04
Hydrophobic TM3 R 133 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 I 67 N.s5s6.08
Polar H8 S 307 8x47 s5s6 E 65 N.s5s6.06
Polar H8 N 309 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 309 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 309 8x49 s5s6 E 65 N.s5s6.06
Polar ICL2 R 141 34x51 S15 V 238 C.S15.14
Polar TM6 S 238 6x26 s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 147 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 147 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 147 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 147 34x57 s5s6 D 63 N.s5s6.04
Polar TM6 S 241 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 S 241 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 A 136 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 136 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 137 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 137 3x54 S6 F 71 N.S6.01
Hydrophobic TM5 L 227 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 227 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 S 241 6x29 s5s6 L 69 N.s5s6.10
Polar ICL2 S 144 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 S 144 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 144 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 T 248 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 248 6x36 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 141 34x51 S16 D 244 C.S16.01
Polar ICL2 R 141 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 R 141 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 R 141 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 R 141 34x51 S16 K 245 C.S16.02
Hydrophobic TM3 R 133 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 S 140 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 S 140 34x50 S16 D 244 C.S16.01
Hydrophobic ICL3 M 234 - S6 K 73 N.S6.03
Van-der-waals ICL3 M 234 - S6 K 73 N.S6.03
Polar C-term R 323 - s20c E 386 C.s20c.20
Hydrophobic C-term R 323 - s20c E 386 C.s20c.20
Van-der-waals C-term R 323 - s20c E 386 C.s20c.20
Hydrophobic TM5 Y 220 5x58 s5s6 I 67 N.s5s6.08
Polar TM5 H 226 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 226 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 S 238 6x26 S6 K 73 N.S6.03
Polar TM6 T 245 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 T 245 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 245 6x33 s5s6 L 69 N.s5s6.10