Beta-arrestin-2 - GAL2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GAL2 74.5
Beta-arrestin-2 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term C 362 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 362 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 362 - s17s18 R 286 C.s17s18.11
Hydrophobic TM2 T 60 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 234 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 234 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 130 34x50 s15s16 S 246 C.s15s16.04
Ionic H8 H 298 8x49 s5s6 E 67 N.s5s6.03
Polar H8 H 298 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 H 298 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 H 298 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 L 131 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 131 34x51 S16 Y 250 C.S16.03
Polar C-term A 387 - s6h1 N 93 N.s6h1.06
Hydrophobic C-term A 387 - s6h1 N 93 N.s6h1.06
Van-der-waals C-term A 387 - s6h1 N 93 N.s6h1.06
Ionic C-term E 365 - S16 K 251 C.S16.04
Polar C-term E 365 - S16 K 251 C.S16.04
Hydrophobic C-term E 365 - S16 K 251 C.S16.04
Van-der-waals C-term E 365 - S16 K 251 C.S16.04
Polar TM2 S 58 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 58 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 58 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 Y 213 5x64 S6 F 76 N.S6.01
Hydrophobic ICL2 R 134 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 134 34x54 s5s6 R 66 N.s5s6.02
Polar TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 60 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 127 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 127 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 214 5x65 S6 F 76 N.S6.01
Hydrophobic TM3 I 127 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 127 3x54 S6 F 76 N.S6.01
Hydrophobic C-term Q 360 - S16 P 253 C.S16.06
Ionic ICL2 R 134 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 134 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 134 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 134 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 137 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 127 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 I 64 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 131 34x51 S16 A 248 C.S16.01
Hydrophobic C-term C 362 - s17s18 K 285 C.s17s18.10
Polar C-term I 363 - S16 K 251 C.S16.04
Van-der-waals C-term I 363 - S16 K 251 C.S16.04
Hydrophobic C-term C 362 - s17s18 G 287 C.s17s18.12
Hydrophobic C-term W 372 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term W 372 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term C 367 - S16 Q 249 C.S16.02
Van-der-waals C-term C 367 - S16 Q 249 C.S16.02
Hydrophobic C-term L 364 - S16 A 248 C.S16.01
Polar C-term C 362 - S16 C 252 C.S16.05
Hydrophobic C-term C 362 - S16 C 252 C.S16.05
Van-der-waals C-term C 362 - S16 C 252 C.S16.05
Hydrophobic TM3 R 123 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 123 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 134 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 R 134 34x54 s8s9 A 140 N.s8s9.10
Ionic H8 H 298 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 H 298 8x49 s5s6 D 70 N.s5s6.06
Polar TM2 T 59 2x38 s5s6 D 68 N.s5s6.04
Polar TM5 Y 213 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Y 213 5x64 s15s16 F 245 C.s15s16.03
Polar H8 H 298 8x49 s20c Q 407 C.s20c.17
Hydrophobic H8 H 298 8x49 s20c Q 407 C.s20c.17
Van-der-waals H8 H 298 8x49 s20c Q 407 C.s20c.17
Hydrophobic TM6 V 234 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 234 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 131 34x51 S8 L 130 N.S8.03
Polar ICL2 H 132 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 H 132 34x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 H 132 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic TM3 A 126 3x53 s5s6 L 69 N.s5s6.05
Polar C-term V 386 - s6h1 N 93 N.s6h1.06
Polar H8 K 297 8x48 s20c C 409 C.s20c.19
Van-der-waals H8 K 297 8x48 s20c C 409 C.s20c.19
Polar C-term E 365 - S16 Q 249 C.S16.02
Van-der-waals C-term E 365 - S16 Q 249 C.S16.02
Hydrophobic H8 S 296 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 131 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 214 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 214 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic C-term C 362 - S16 K 251 C.S16.04
Van-der-waals C-term C 362 - S16 K 251 C.S16.04
Polar C-term C 323 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 323 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 323 - s1s2 C 17 N.s1s2.04
Polar C-term Q 360 - S16 Q 256 C.S16.09
Polar ICL2 L 131 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 131 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 131 34x51 S5 Y 64 N.S5.12
Van-der-waals C-term L 364 - S16 Q 249 C.S16.02
Polar ICL2 H 132 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 H 132 34x52 s15s16 S 246 C.s15s16.04
Polar ICL2 P 130 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 130 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 130 34x50 S5 Y 64 N.S5.12
Ionic ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 137 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 V 218 5x69 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 V 218 5x69 S6 F 76 N.S6.01
Van-der-waals TM5 V 218 5x69 S6 F 76 N.S6.01
Hydrophobic TM6 V 234 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 I 127 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 H 132 34x52 S16 A 248 C.S16.01
Van-der-waals ICL2 H 132 34x52 S16 A 248 C.S16.01
Hydrophobic ICL2 L 131 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 131 34x51 S15 I 242 C.S15.14
Hydrophobic C-term L 364 - S16 Y 250 C.S16.03
Van-der-waals C-term L 364 - S16 Y 250 C.S16.03