S-arrestin - GAL3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GAL3 76.0
S-arrestin 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 F 210 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 R 134 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 134 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 124 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 M 237 6x37 s5s6 V 78 N.s5s6.07
Ionic H8 H 297 8x49 s5s6 E 74 N.s5s6.03
Polar H8 H 297 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 H 297 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 H 297 8x49 s5s6 E 74 N.s5s6.03
Ionic TM6 R 228 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 228 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 228 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 228 6x28 s9s10 E 164 N.s9s10.06
Ionic H8 R 303 8x55 s20c E 405 C.s20c.24
Polar H8 R 303 8x55 s20c E 405 C.s20c.24
Hydrophobic H8 R 303 8x55 s20c E 405 C.s20c.24
Van-der-waals H8 R 303 8x55 s20c E 405 C.s20c.24
Ionic H8 R 296 8x48 s9s10 D 166 N.s9s10.08
Polar ICL2 R 129 34x52 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 R 129 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 L 128 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 128 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 L 128 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 128 34x51 S8 L 136 N.S8.03
Polar ICL2 L 128 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 128 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 128 34x51 S16 Y 259 C.S16.03
Polar ICL2 P 127 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 127 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 127 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 128 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 128 34x51 S16 D 257 C.S16.01
Hydrophobic TM5 L 211 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 R 131 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 131 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 Y 204 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 V 124 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 124 3x54 S6 F 83 N.S6.01
Ionic ICL2 R 129 34x52 S16 D 257 C.S16.01
Polar ICL2 R 129 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 R 129 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 R 129 34x52 S16 D 257 C.S16.01
Hydrophobic TM3 A 123 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 R 131 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 R 131 34x54 s8s9 P 138 N.s8s9.02
Hydrophobic TM6 R 226 6x26 S6 R 85 N.S6.03
Ionic C-term R 310 - s20c D 404 C.s20c.23
Polar C-term R 310 - s20c D 404 C.s20c.23
Hydrophobic C-term R 310 - s20c D 404 C.s20c.23
Van-der-waals C-term R 310 - s20c D 404 C.s20c.23
Ionic ICL2 R 131 34x54 s8s9 D 142 N.s8s9.06
Ionic TM6 R 232 6x32 s9s10 D 166 N.s9s10.08
Polar TM6 R 232 6x32 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 232 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 A 221 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL2 L 128 34x51 S9 C 147 N.S9.01
Hydrophobic TM6 A 233 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 233 6x33 s5s6 L 81 N.s5s6.10
Polar TM2 Q 51 2x33 s20c R 398 C.s20c.17
Hydrophobic TM6 A 236 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 236 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 R 131 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 131 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 131 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 M 237 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 237 6x37 s5s6 I 79 N.s5s6.08
Ionic ICL2 R 134 34x57 s5s6 D 75 N.s5s6.04
Polar ICL2 R 134 34x57 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 R 134 34x57 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 R 134 34x57 s5s6 D 75 N.s5s6.04
Polar H8 S 295 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 295 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 295 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 P 127 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 L 211 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 M 237 6x37 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 M 237 6x37 s5s6 L 81 N.s5s6.10
Polar H8 H 297 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 H 297 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 H 297 8x49 s5s6 D 77 N.s5s6.06
Polar TM2 Q 51 2x33 s5s6 E 74 N.s5s6.03
Van-der-waals TM2 Q 51 2x33 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 L 128 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 128 34x51 S5 Y 71 N.S5.12
Polar H8 R 296 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 296 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 296 8x48 s5s6 D 77 N.s5s6.06
Polar TM2 T 57 2x39 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 57 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 120 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 120 3x50 s5s6 V 78 N.s5s6.07