Beta-arrestin-1 - CCK2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
CCK2 75.1
Beta-arrestin-1 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 R 319 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 R 319 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 319 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 Q 166 34x57 s5s6 L 68 N.s5s6.05
Ionic H8 R 396 8x49 s5s6 E 66 N.s5s6.03
Polar H8 R 396 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 R 396 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 396 8x49 s5s6 E 66 N.s5s6.03
Polar C-term E 423 - s20c N 416 C.s20c.26
Hydrophobic TM3 I 156 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 V 164 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 164 34x55 S16 Y 249 C.S16.03
Hydrophobic TM6 M 334 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 334 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 R 163 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 159 34x50 S5 Y 63 N.S5.12
Hydrophobic TM3 I 156 3x54 S6 F 75 N.S6.01
Polar TM4 T 167 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 T 167 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 163 34x54 S9 C 140 N.S9.01
Van-der-waals ICL2 R 163 34x54 S9 C 140 N.S9.01
Hydrophobic TM3 A 155 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 245 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 245 5x65 s5s6 L 73 N.s5s6.10
Ionic H8 H 394 8x47 s5s6 D 69 N.s5s6.06
Polar H8 H 394 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 H 394 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 H 394 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 160 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 160 34x51 S16 A 247 C.S16.01
Hydrophobic H8 H 394 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 H 394 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 160 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL1 R 84 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 R 84 12x49 s20c E 404 C.s20c.14
Ionic ICL1 R 84 12x49 s20c E 407 C.s20c.17
Polar ICL1 R 84 12x49 s20c E 407 C.s20c.17
Hydrophobic ICL1 R 84 12x49 s20c E 407 C.s20c.17
Van-der-waals ICL1 R 84 12x49 s20c E 407 C.s20c.17
Polar TM2 T 87 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 T 87 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 87 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 A 327 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 V 88 2x38 s5s6 L 68 N.s5s6.05
Hydrophobic TM4 T 167 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 T 167 4x38 s17s18 R 285 C.s17s18.11
Polar TM4 R 168 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 168 4x39 s8s9 E 134 N.s8s9.05
Polar ICL2 Q 166 34x57 s17s18 R 285 C.s17s18.11
Polar TM4 S 169 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 S 169 4x40 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 S 169 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 V 331 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 L 160 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 160 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 160 34x51 S16 Y 249 C.S16.03
Polar ICL2 R 163 34x54 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 R 163 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 163 34x54 s17s18 R 285 C.s17s18.11
Polar TM6 K 324 6x26 S6 R 76 N.S6.02
Polar TM2 T 89 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 152 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 152 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 R 163 34x54 s8s9 P 131 N.s8s9.02
Polar ICL2 R 163 34x54 S8 L 129 N.S8.03
Van-der-waals ICL2 R 163 34x54 S8 L 129 N.S8.03
Polar C-term D 424 - s20c N 416 C.s20c.26
Hydrophobic C-term D 424 - s20c N 416 C.s20c.26
Van-der-waals C-term D 424 - s20c N 416 C.s20c.26
Polar ICL2 Q 166 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 166 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 166 34x57 s5s6 R 65 N.s5s6.02
Ionic TM6 K 324 6x26 S6 D 78 N.S6.04
Polar TM6 K 324 6x26 S6 D 78 N.S6.04
Hydrophobic TM6 L 335 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 335 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 155 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 160 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 160 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 V 331 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 331 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 160 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 R 163 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 R 163 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic ICL2 L 160 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 160 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 K 328 6x30 s5s6 L 73 N.s5s6.10
Polar TM3 C 157 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 C 157 3x55 s15s16 N 245 C.s15s16.04
Polar ICL2 V 164 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 V 164 34x55 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 V 164 34x55 s17s18 R 285 C.s17s18.11