ArrestinDb

Beta-arrestin-2 - CCK₂ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
CCK₂	75.0
Beta-arrestin-2	81.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.6

PAE mean: 15.4

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL1	R	84	12x49	s20c	Y	404	C.s20c.14
Hydrophobic	TM4	S	169	4x40	s8s9	E	135	N.s8s9.05
Hydrophobic	ICL2	R	163	34x54	S8	L	130	N.S8.03
Hydrophobic	ICL2	P	159	34x50	S5	Y	64	N.S5.12
Hydrophobic	TM3	I	156	3x54	S6	F	76	N.S6.01
Hydrophobic	ICL2	L	160	34x51	S15	I	242	C.S15.14
Hydrophobic	TM4	T	167	4x38	s17s18	R	286	C.s17s18.11
Hydrophobic	TM4	T	167	4x38	s8s9	E	135	N.s8s9.05
Hydrophobic	TM3	A	155	3x53	s5s6	L	69	N.s5s6.05
Hydrophobic	TM3	I	156	3x54	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	R	163	34x54	s8s9	A	140	N.s8s9.10
Hydrophobic	TM3	R	152	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	L	160	34x51	s15s16	T	247	C.s15s16.05
Hydrophobic	H8	H	394	8x47	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	I	156	3x54	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL1	R	84	12x49	s20c	Y	404	C.s20c.14
Hydrophobic	TM5	L	245	5x65	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	P	159	34x50	s15s16	S	246	C.s15s16.04
Hydrophobic	TM5	L	245	5x65	S6	F	76	N.S6.01
Hydrophobic	ICL2	Q	166	34x57	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL3	R	319	-	s9s10	E	156	N.s9s10.07
Hydrophobic	TM4	R	168	4x39	s8s9	E	135	N.s8s9.05
Hydrophobic	H8	R	396	8x49	s5s6	E	67	N.s5s6.03
Hydrophobic	TM2	T	87	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	ICL2	R	163	34x54	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	R	163	34x54	s8s9	Q	131	N.s8s9.01
Hydrophobic	TM2	T	89	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	L	160	34x51	S16	A	248	C.S16.01
Hydrophobic	ICL2	R	163	34x54	S9	C	141	N.S9.01
Hydrophobic	TM6	M	334	6x36	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	V	331	6x33	s5s6	L	74	N.s5s6.10
Hydrophobic	TM6	K	328	6x30	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	V	164	34x55	S16	Y	250	C.S16.03
Hydrophobic	ICL2	R	163	34x54	s8s9	P	132	N.s8s9.02
Hydrophobic	ICL2	L	160	34x51	s15s16	S	246	C.s15s16.04
Hydrophobic	H8	H	394	8x47	s5s6	L	72	N.s5s6.08
Hydrophobic	H8	R	396	8x49	s5s6	D	70	N.s5s6.06
Hydrophobic	TM6	L	335	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	L	160	34x51	S16	Y	250	C.S16.03
Hydrophobic	TM6	V	331	6x33	s5s6	L	72	N.s5s6.08
Ionic	ICL2	R	163	34x54	s8s9	D	136	N.s8s9.06
Ionic	H8	R	396	8x49	s5s6	E	67	N.s5s6.03
Ionic	TM6	K	324	6x26	S6	D	79	N.S6.04
Ionic	H8	R	396	8x49	s5s6	D	70	N.s5s6.06
Polar	TM4	S	169	4x40	s8s9	E	135	N.s8s9.05
Polar	ICL2	R	163	34x54	S8	L	130	N.S8.03
Polar	C-term	Y	438	-	ns1	E	3	N.ns1.10
Polar	ICL2	R	163	34x54	s8s9	D	136	N.s8s9.06
Polar	TM4	T	167	4x38	s8s9	E	135	N.s8s9.05
Polar	H8	H	394	8x47	s5s6	V	71	N.s5s6.07
Polar	TM6	K	324	6x26	S6	R	77	N.S6.02
Polar	TM2	V	88	2x38	s5s6	D	68	N.s5s6.04
Polar	ICL2	Q	166	34x57	s5s6	R	66	N.s5s6.02
Polar	ICL3	R	319	-	s9s10	E	156	N.s9s10.07
Polar	TM4	R	168	4x39	s8s9	E	135	N.s8s9.05
Polar	H8	R	396	8x49	s5s6	E	67	N.s5s6.03
Polar	ICL2	R	163	34x54	s5s6	R	66	N.s5s6.02
Polar	ICL2	R	163	34x54	s8s9	Q	131	N.s8s9.01
Polar	TM6	K	324	6x26	S6	D	79	N.S6.04
Polar	H8	R	396	8x49	s5s6	D	70	N.s5s6.06
Polar	ICL2	L	160	34x51	S16	Y	250	C.S16.03
Van-der-waals	TM4	S	169	4x40	s8s9	E	135	N.s8s9.05
Van-der-waals	ICL2	R	163	34x54	S8	L	130	N.S8.03
Van-der-waals	ICL2	P	159	34x50	S5	Y	64	N.S5.12
Van-der-waals	ICL2	L	160	34x51	S15	I	242	C.S15.14
Van-der-waals	TM4	T	167	4x38	s17s18	R	286	C.s17s18.11
Van-der-waals	TM4	T	167	4x38	s8s9	E	135	N.s8s9.05
Van-der-waals	TM3	A	155	3x53	s5s6	L	69	N.s5s6.05
Van-der-waals	TM3	I	156	3x54	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	R	163	34x54	s8s9	A	140	N.s8s9.10
Van-der-waals	H8	H	394	8x47	s5s6	V	71	N.s5s6.07
Van-der-waals	TM3	I	156	3x54	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL1	R	84	12x49	s20c	Y	404	C.s20c.14
Van-der-waals	TM5	L	245	5x65	s5s6	L	74	N.s5s6.10
Van-der-waals	TM2	V	88	2x38	s5s6	D	68	N.s5s6.04
Van-der-waals	ICL2	Q	166	34x57	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL3	R	319	-	s9s10	E	156	N.s9s10.07
Van-der-waals	TM4	R	168	4x39	s8s9	E	135	N.s8s9.05
Van-der-waals	H8	R	396	8x49	s5s6	E	67	N.s5s6.03
Van-der-waals	TM2	T	87	2x37	s5s6	D	68	N.s5s6.04
Van-der-waals	TM3	R	152	3x50	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	R	163	34x54	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	L	160	34x51	S16	A	248	C.S16.01
Van-der-waals	ICL2	R	163	34x54	S9	C	141	N.S9.01
Van-der-waals	TM6	M	334	6x36	s5s6	L	72	N.s5s6.08
Van-der-waals	TM6	K	328	6x30	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	R	163	34x54	s8s9	P	132	N.s8s9.02
Van-der-waals	TM6	K	324	6x26	S6	D	79	N.S6.04
Van-der-waals	ICL2	L	160	34x51	s15s16	S	246	C.s15s16.04
Van-der-waals	H8	R	396	8x49	s5s6	D	70	N.s5s6.06
Van-der-waals	ICL2	L	160	34x51	S16	Y	250	C.S16.03
Van-der-waals	TM6	V	331	6x33	s5s6	L	72	N.s5s6.08

Showing 1 to 92 of 92 entries

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Main reference

Beta-arrestin-2 - CCK2 receptor complex model Download Full