Beta-arrestin-2 - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GHRH 78.8
Beta-arrestin-2 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 156 12x49 s20c L 408 C.s20c.18
Hydrophobic TM3 L 227 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 227 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 H 165 2x50 s5s6 V 71 N.s5s6.07
Polar ICL2 P 236 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 236 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 236 - s8s9 T 137 N.s8s9.07
Hydrophobic TM5 I 303 5x57 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 236 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 P 236 - s8s9 E 135 N.s8s9.05
Polar H8 E 382 8x49 s20c C 409 C.s20c.19
Hydrophobic TM3 L 231 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 231 3x58 s5s6 L 69 N.s5s6.05
Polar ICL2 T 234 - S16 Y 250 C.S16.03
Aromatic TM5 K 310 5x64 S6 F 76 N.S6.01
Hydrophobic TM5 K 310 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 310 5x64 S6 F 76 N.S6.01
Hydrophobic ICL3 A 314 - S6 K 78 N.S6.03
Van-der-waals ICL3 A 314 - S6 K 78 N.S6.03
Hydrophobic TM3 L 231 3x58 S6 F 76 N.S6.01
Polar TM2 C 159 2x44 s20c C 409 C.s20c.19
Hydrophobic TM2 C 159 2x44 s20c C 409 C.s20c.19
Van-der-waals TM2 C 159 2x44 s20c C 409 C.s20c.19
Van-der-waals ICL2 T 234 - s15s16 S 246 C.s15s16.04
Polar TM6 S 330 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 330 6x41 s5s6 L 72 N.s5s6.08
Polar TM3 S 233 3x60 s5s6 R 66 N.s5s6.02
Hydrophobic H8 E 386 8x53 s20c L 408 C.s20c.18
Hydrophobic ICL1 H 158 12x51 s20c C 409 C.s20c.19
Ionic ICL1 R 156 12x49 s20c D 406 C.s20c.16
Polar ICL1 R 156 12x49 s20c D 406 C.s20c.16
Van-der-waals ICL1 R 156 12x49 s20c D 406 C.s20c.16
Hydrophobic ICL2 S 238 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 238 - s8s9 T 137 N.s8s9.07
Hydrophobic H8 E 382 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 E 382 8x49 s20c L 408 C.s20c.18
Polar TM2 N 162 2x47 s20c C 409 C.s20c.19
Hydrophobic TM2 N 162 2x47 s20c C 409 C.s20c.19
Van-der-waals TM2 N 162 2x47 s20c C 409 C.s20c.19
Polar TM2 R 161 2x46 s20c C 409 C.s20c.19
Hydrophobic TM2 R 161 2x46 s20c C 409 C.s20c.19
Hydrophobic ICL2 T 234 - S16 A 248 C.S16.01
Van-der-waals ICL2 T 234 - S16 A 248 C.S16.01
Hydrophobic TM3 L 230 3x57 s5s6 D 68 N.s5s6.04
Ionic H8 R 403 8x70 S20 D 390 C.S20.05
Polar H8 R 403 8x70 S20 D 390 C.S20.05
Polar ICL1 L 157 12x50 s20c C 409 C.s20c.19
Hydrophobic ICL1 L 157 12x50 s20c C 409 C.s20c.19
Van-der-waals ICL1 L 157 12x50 s20c C 409 C.s20c.19
Hydrophobic TM2 R 161 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 161 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 S 330 6x41 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 S 330 6x41 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 334 6x45 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 334 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 227 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 227 3x54 s5s6 L 69 N.s5s6.05
Polar ICL2 S 235 - s8s9 T 137 N.s8s9.07
Hydrophobic TM5 K 310 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 310 5x64 s15s16 F 245 C.s15s16.03
Polar TM2 R 161 2x46 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 R 161 2x46 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 P 236 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 236 - s8s9 D 136 N.s8s9.06
Hydrophobic TM7 Y 376 7x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 376 7x57 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 307 5x61 S6 F 76 N.S6.01
Van-der-waals TM5 L 307 5x61 S6 F 76 N.S6.01
Hydrophobic TM5 L 307 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 307 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 T 234 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 T 234 - s15s16 T 247 C.s15s16.05
Polar TM3 L 230 3x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 230 3x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 230 3x57 s5s6 R 66 N.s5s6.02
Ionic TM2 R 161 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 161 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 161 2x46 s5s6 D 68 N.s5s6.04