S-arrestin - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GHRH 78.4
S-arrestin 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 H 165 2x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 H 165 2x50 s5s6 V 78 N.s5s6.07
Polar ICL3 E 312 - S6 R 85 N.S6.03
Van-der-waals ICL3 E 312 - S6 R 85 N.S6.03
Hydrophobic ICL2 T 234 - S16 D 257 C.S16.01
Van-der-waals ICL2 T 234 - S16 D 257 C.S16.01
Van-der-waals H8 Q 381 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 L 227 3x54 s5s6 I 79 N.s5s6.08
Polar ICL2 T 234 - S16 Y 259 C.S16.03
Hydrophobic TM5 L 307 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 307 5x61 s5s6 L 81 N.s5s6.10
Polar ICL2 T 234 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 234 - s8s9 K 145 N.s8s9.09
Polar TM3 S 233 3x60 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 S 233 3x60 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 A 314 - S6 R 85 N.S6.03
Ionic H8 R 405 8x72 s20c E 392 C.s20c.11
Polar H8 R 405 8x72 s20c E 392 C.s20c.11
Hydrophobic H8 R 405 8x72 s20c E 392 C.s20c.11
Van-der-waals H8 R 405 8x72 s20c E 392 C.s20c.11
Hydrophobic TM3 L 231 3x58 S6 F 83 N.S6.01
Hydrophobic C-term W 408 - s20c K 388 C.s20c.07
Van-der-waals C-term W 408 - s20c K 388 C.s20c.07
Hydrophobic ICL2 T 234 - s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 P 236 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 236 - s8s9 K 145 N.s8s9.09
Polar TM5 K 310 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 310 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 310 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 S 330 6x41 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 330 6x41 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 K 310 5x64 S6 F 83 N.S6.01
Aromatic TM5 K 310 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 K 310 5x64 S6 F 83 N.S6.01
Hydrophobic ICL2 P 236 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 P 236 - s8s9 D 142 N.s8s9.06
Hydrophobic TM5 L 307 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 334 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 307 5x61 S6 F 83 N.S6.01
Van-der-waals TM5 L 307 5x61 S6 F 83 N.S6.01
Hydrophobic TM2 R 161 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 161 2x46 s5s6 V 78 N.s5s6.07
Polar TM2 R 161 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 R 161 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 161 2x46 s5s6 D 75 N.s5s6.04
Polar TM6 H 319 6x30 s9s10 A 163 N.s9s10.05
Hydrophobic TM6 H 319 6x30 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 H 319 6x30 s9s10 A 163 N.s9s10.05
Polar TM6 S 330 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 330 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 330 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 A 314 - S6 L 87 N.S6.05
Hydrophobic H8 E 382 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 E 382 8x49 s5s6 D 75 N.s5s6.04
Polar ICL3 P 313 - S6 R 85 N.S6.03
Hydrophobic TM7 Y 376 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 376 7x57 s5s6 V 78 N.s5s6.07