Beta-arrestin-1 - ghrelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
ghrelin 82.4
Beta-arrestin-1 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 76 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 76 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 R 150 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 150 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 150 34x52 s15s16 N 245 C.s15s16.04
Polar ICL2 K 152 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 K 152 34x54 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 K 152 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 V 153 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 153 34x55 S16 Y 249 C.S16.03
Polar TM5 R 242 5x68 S5 Y 63 N.S5.12
Hydrophobic TM5 R 242 5x68 S5 Y 63 N.S5.12
Van-der-waals TM5 R 242 5x68 S5 Y 63 N.S5.12
Hydrophobic ICL1 E 73 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 V 155 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 155 34x57 s5s6 R 65 N.s5s6.02
Ionic TM4 K 161 4x43 s8s9 E 134 N.s8s9.05
Aromatic TM5 R 242 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 242 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 242 5x68 s15s16 F 244 C.s15s16.03
Ionic H8 K 328 8x48 s20c E 405 C.s20c.15
Polar H8 K 328 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 K 328 8x48 s20c E 405 C.s20c.15
Hydrophobic TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Polar ICL2 K 152 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 K 152 34x54 s8s9 A 139 N.s8s9.10
Ionic H8 K 329 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 329 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 329 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 A 144 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 149 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 L 149 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic TM3 I 145 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 I 145 3x54 s5s6 L 68 N.s5s6.05
Polar TM6 T 261 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 261 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 261 6x33 s5s6 L 71 N.s5s6.08
Polar H8 S 327 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 327 8x47 s5s6 V 70 N.s5s6.07
Ionic H8 R 336 8x56 s20c E 405 C.s20c.15
Polar TM2 T 77 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 77 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 148 34x50 S6 F 75 N.S6.01
Hydrophobic ICL2 K 152 34x54 s5s6 R 65 N.s5s6.02
Polar TM2 T 77 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 148 34x50 S5 Y 63 N.S5.12
Ionic TM3 E 140 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 E 140 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 E 140 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 A 144 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 144 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 149 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 149 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 149 34x51 s15s16 N 245 C.s15s16.04
Polar TM4 G 158 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 H 258 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 258 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 T 261 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 T 261 6x33 s5s6 L 73 N.s5s6.10
Polar TM4 K 157 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 K 157 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 K 157 4x39 s8s9 E 134 N.s8s9.05
Ionic H8 K 328 8x48 s20c E 407 C.s20c.17
Polar H8 K 328 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 K 328 8x48 s20c E 407 C.s20c.17
Hydrophobic ICL2 L 149 34x51 S9 C 140 N.S9.01
Polar TM6 R 254 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 R 254 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 R 254 6x26 S6 R 76 N.S6.02
Ionic H8 K 329 8x49 s5s6 E 66 N.s5s6.03
Polar H8 K 329 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 329 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 329 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic C-term S 349 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term S 349 - s9s10 R 161 N.s9s10.13
Hydrophobic ICL2 L 149 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 149 34x51 S15 I 241 C.S15.14
Polar C-term L 348 - s9s10 R 161 N.s9s10.13
Hydrophobic ICL2 P 148 34x50 s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 P 148 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 L 265 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 R 242 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 242 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 L 239 5x65 s5s6 L 73 N.s5s6.10
Polar C-term R 346 - s20c G 411 C.s20c.21
Hydrophobic TM2 T 78 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals ICL2 K 152 34x54 S9 C 140 N.S9.01
Polar ICL2 L 149 34x51 S16 Y 249 C.S16.03
Polar ICL2 K 152 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 K 152 34x54 s8s9 K 138 N.s8s9.09
Ionic TM6 R 254 6x26 S6 D 78 N.S6.04
Polar TM6 R 254 6x26 S6 D 78 N.S6.04
Hydrophobic TM6 R 254 6x26 S6 D 78 N.S6.04
Van-der-waals TM6 R 254 6x26 S6 D 78 N.S6.04
Hydrophobic TM7 M 326 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 M 326 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 A 151 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 141 3x50 s5s6 L 71 N.s5s6.08