Beta-arrestin-2 - GIP receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GIP 77.6
Beta-arrestin-2 77.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 244 3x57 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 L 244 3x57 s5s6 D 68 N.s5s6.04
Ionic TM2 R 169 2x46 s5s6 D 68 N.s5s6.04
Polar TM2 R 169 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 169 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 169 2x46 s5s6 D 68 N.s5s6.04
Polar ICL2 E 252 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 E 252 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 E 252 - s8s9 T 137 N.s8s9.07
Polar TM6 R 338 6x37 s5s6 S 75 N.s5s6.11
Polar TM3 L 244 3x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 244 3x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 244 3x57 s5s6 R 66 N.s5s6.02
Polar ICL1 H 166 12x51 s20c C 409 C.s20c.19
Hydrophobic ICL1 H 166 12x51 s20c C 409 C.s20c.19
Van-der-waals ICL1 H 166 12x51 s20c C 409 C.s20c.19
Polar ICL2 G 250 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 G 250 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 G 250 - s8s9 T 137 N.s8s9.07
Polar TM5 R 328 5x68 S6 R 77 N.S6.02
Hydrophobic TM5 R 328 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 R 328 5x68 S6 R 77 N.S6.02
Hydrophobic ICL2 V 248 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 V 248 - s15s16 T 247 C.s15s16.05
Hydrophobic TM7 Y 392 7x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 392 7x57 s5s6 V 71 N.s5s6.07
Polar ICL1 L 165 12x50 s20c C 409 C.s20c.19
Hydrophobic ICL1 L 165 12x50 s20c C 409 C.s20c.19
Van-der-waals ICL1 L 165 12x50 s20c C 409 C.s20c.19
Polar TM6 S 342 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 342 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic H8 E 402 8x53 s20c L 408 C.s20c.18
Van-der-waals H8 E 402 8x53 s20c L 408 C.s20c.18
Polar H8 E 398 8x49 s20c C 409 C.s20c.19
Hydrophobic H8 E 398 8x49 s20c C 409 C.s20c.19
Van-der-waals H8 E 398 8x49 s20c C 409 C.s20c.19
Hydrophobic H8 E 398 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 E 398 8x49 s20c L 408 C.s20c.18
Polar ICL1 R 164 12x49 s20c C 409 C.s20c.19
Hydrophobic ICL1 R 164 12x49 s20c C 409 C.s20c.19
Van-der-waals ICL1 R 164 12x49 s20c C 409 C.s20c.19
Hydrophobic ICL2 V 248 - S16 A 248 C.S16.01
Van-der-waals ICL2 V 248 - S16 A 248 C.S16.01
Hydrophobic TM2 R 169 2x46 s5s6 E 67 N.s5s6.03
Ionic ICL2 E 252 - s5s6 R 66 N.s5s6.02
Polar ICL2 E 252 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 E 252 - s5s6 R 66 N.s5s6.02
Hydrophobic H8 N 396 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 346 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 R 169 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 169 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 K 324 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 324 5x64 s15s16 F 245 C.s15s16.03
Aromatic TM5 K 324 5x64 S6 F 76 N.S6.01
Hydrophobic TM5 K 324 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 324 5x64 S6 F 76 N.S6.01
Hydrophobic ICL2 S 251 - s8s9 T 137 N.s8s9.07
Polar TM2 R 169 2x46 s20c L 408 C.s20c.18
Van-der-waals TM2 R 169 2x46 s20c L 408 C.s20c.18
Hydrophobic TM6 T 345 6x44 s5s6 L 72 N.s5s6.08
Polar TM2 C 167 2x44 s20c C 409 C.s20c.19
Hydrophobic TM2 C 167 2x44 s20c C 409 C.s20c.19
Van-der-waals TM2 C 167 2x44 s20c C 409 C.s20c.19
Hydrophobic TM3 L 241 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic H8 S 401 8x52 s20c L 408 C.s20c.18
Van-der-waals H8 S 401 8x52 s20c L 408 C.s20c.18
Ionic TM6 R 331 6x30 s9s10 E 156 N.s9s10.07
Polar TM6 R 331 6x30 s9s10 E 156 N.s9s10.07
Hydrophobic TM6 R 331 6x30 s9s10 E 156 N.s9s10.07
Van-der-waals TM6 R 331 6x30 s9s10 E 156 N.s9s10.07
Polar TM5 R 328 5x68 s5s6 S 75 N.s5s6.11
Van-der-waals TM5 R 328 5x68 s5s6 S 75 N.s5s6.11
Ionic H8 R 405 8x56 s20c D 406 C.s20c.16
Hydrophobic ICL2 G 249 - S16 A 248 C.S16.01
Ionic ICL1 R 164 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 164 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 164 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL2 S 251 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 S 251 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 E 253 - s8s9 P 134 N.s8s9.04
Hydrophobic TM5 L 321 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 321 5x61 s5s6 L 74 N.s5s6.10
Polar TM2 N 170 2x47 s20c C 409 C.s20c.19
Hydrophobic TM2 N 170 2x47 s20c C 409 C.s20c.19
Van-der-waals TM2 N 170 2x47 s20c C 409 C.s20c.19
Hydrophobic TM2 R 169 2x46 s20c C 409 C.s20c.19
Van-der-waals TM2 R 169 2x46 s20c C 409 C.s20c.19
Hydrophobic TM3 L 241 3x54 s5s6 L 72 N.s5s6.08
Polar TM6 R 338 6x37 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 338 6x37 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 L 245 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 245 3x58 s5s6 L 69 N.s5s6.05