S-arrestin - GIP receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GIP 76.7
S-arrestin 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 328 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 R 328 5x68 S6 F 83 N.S6.01
Hydrophobic TM6 S 342 6x41 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 342 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 R 169 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 169 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 S 342 6x41 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 342 6x41 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 L 245 3x58 S6 F 83 N.S6.01
Hydrophobic TM3 L 244 3x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 248 - S16 D 257 C.S16.01
Van-der-waals ICL2 V 248 - S16 D 257 C.S16.01
Polar TM5 K 324 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 324 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 324 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 G 250 - s8s9 K 145 N.s8s9.09
Aromatic TM5 K 324 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 K 324 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 K 324 5x64 S6 F 83 N.S6.01
Hydrophobic TM7 Y 392 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 392 7x57 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 L 321 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 321 5x61 s5s6 L 81 N.s5s6.10
Polar TM5 R 328 5x68 s5s6 T 82 N.s5s6.11
Van-der-waals TM5 R 328 5x68 s5s6 T 82 N.s5s6.11
Polar TM5 R 328 5x68 s15s16 Y 254 C.s15s16.03
Ionic H8 K 397 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 397 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 397 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 397 8x48 s5s6 D 77 N.s5s6.06
Polar TM3 L 244 3x57 S5 Y 71 N.S5.12
Hydrophobic TM6 R 338 6x37 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 338 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 H 173 2x50 s5s6 V 78 N.s5s6.07
Polar TM2 R 169 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 169 2x46 s5s6 D 75 N.s5s6.04
Ionic ICL2 E 252 - s8s9 K 145 N.s8s9.09
Polar ICL2 E 252 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 E 252 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 E 252 - s8s9 K 145 N.s8s9.09
Polar ICL2 E 253 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 E 253 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 E 253 - s8s9 Q 141 N.s8s9.05
Polar TM5 T 327 5x67 S6 R 85 N.S6.03
Hydrophobic TM5 T 327 5x67 S6 R 85 N.S6.03
Van-der-waals TM5 T 327 5x67 S6 R 85 N.S6.03
Hydrophobic TM6 L 346 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 R 328 5x68 S6 R 85 N.S6.03
Polar TM5 R 328 5x68 S6 R 84 N.S6.02
Hydrophobic TM5 R 328 5x68 S6 R 84 N.S6.02
Van-der-waals TM5 R 328 5x68 S6 R 84 N.S6.02
Van-der-waals ICL2 V 248 - s15s16 S 255 C.s15s16.04
Ionic TM6 R 331 6x30 s9s10 D 162 N.s9s10.04
Polar TM6 R 331 6x30 s9s10 D 162 N.s9s10.04
Van-der-waals TM6 R 331 6x30 s9s10 D 162 N.s9s10.04
Polar ICL2 G 249 - S16 D 257 C.S16.01
Van-der-waals ICL2 G 249 - S16 D 257 C.S16.01
Hydrophobic H8 E 398 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 G 249 - S16 Y 259 C.S16.03
Hydrophobic ICL2 G 249 - S16 Y 259 C.S16.03
Van-der-waals ICL2 G 249 - S16 Y 259 C.S16.03
Hydrophobic ICL2 V 248 - s15s16 S 256 C.s15s16.05
Ionic TM6 R 331 6x30 s9s10 E 164 N.s9s10.06
Polar TM6 R 331 6x30 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 331 6x30 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 331 6x30 s9s10 E 164 N.s9s10.06
Hydrophobic ICL2 V 248 - S16 Y 258 C.S16.02
Van-der-waals ICL2 V 248 - S16 Y 258 C.S16.02
Hydrophobic TM5 L 321 5x61 S6 F 83 N.S6.01
Van-der-waals TM5 L 321 5x61 S6 F 83 N.S6.01