S-arrestin - GIP receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GIP 76.7
S-arrestin 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
01
iPTM Score: 0.3
01
PAE mean: 24.1
031


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
D04s5s6R02R03S6Q05K09s8s9E06s9s10Y03s15s16Y03S16ArrestinK5x64G-R5x68R2x46E-T5x67G-R6x30GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsArrestin segments:s5s6S6s8s9s9s10s15s16S16GPCR segments:TM2ICL2TM5TM6

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x433x533x545x655x685x715x726x256x326x366x407x538x488x49C.S16.03C.S16.02C.S16.01C.s15s16.05C.s15s16.04C.s15s16.03N.s9s10.06N.s9s10.04N.s8s9.09N.s8s9.05N.S6.03N.S6.02N.S6.01N.s5s6.11N.s5s6.10N.s5s6.08N.s5s6.07N.s5s6.06N.s5s6.04N.S5.12Res. Pos.GIP (AFM_GIPR_HUMAN_ARRS_HUMAN)- (AFM_GIPR_HUMAN_ARRS_HUMAN)----------------RHLLLKTRRRSLYKERHLLLKTRRRSLYKEVDVYKFLYRRTDEIDDYYSSQ

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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