Gs - GIP receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GIP 81.7
Gαs 86.0
Gβ1 92.7
Gγ2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 244 3x57 G.H5 Y 391 G.H5.23
Polar TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 324 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Polar TM5 R 328 5x68 G.h4s6 H 357 G.h4s6.13
Van-der-waals TM5 R 328 5x68 G.h4s6 H 357 G.h4s6.13
Polar TM5 T 327 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 327 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 244 3x57 G.H5 H 387 G.H5.19
Ionic ICL2 E 253 - G.hns1 R 38 G.hns1.02
Polar ICL2 E 253 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 253 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 253 - G.hns1 R 38 G.hns1.02
Ionic ICL2 E 252 - G.H5 H 387 G.H5.19
Polar ICL2 E 252 - G.H5 H 387 G.H5.19
Hydrophobic TM6 T 345 6x44 G.H5 L 393 G.H5.25
Ionic C-term E 461 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 461 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term E 461 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 461 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 H 173 2x50 G.H5 Y 391 G.H5.23
Ionic ICL2 E 253 - G.HN K 34 G.HN.51
Polar ICL2 E 253 - G.HN K 34 G.HN.51
Hydrophobic ICL2 E 253 - G.HN K 34 G.HN.51
Polar TM6 R 338 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 338 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 338 6x37 G.H5 L 394 G.H5.26
Ionic C-term E 463 - G.H5 R 389 G.H5.21
Polar C-term E 463 - G.H5 R 389 G.H5.21
Hydrophobic C-term E 463 - G.H5 R 389 G.H5.21
Van-der-waals C-term E 463 - G.H5 R 389 G.H5.21
Hydrophobic TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Polar TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic C-term E 463 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 L 321 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 346 6x45 G.H5 L 393 G.H5.25
Polar TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 248 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 248 - G.H5 R 380 G.H5.12
Polar TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Ionic C-term E 463 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 G 249 - G.S3 V 217 G.S3.01
Polar TM6 R 331 6x30 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 R 331 6x30 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM6 R 331 6x30 G.h4s6 T 350 G.h4s6.03
Ionic H8 K 397 8x48 G.H5 E 392 G.H5.24
Polar H8 K 397 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 397 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 397 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 396 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 396 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 248 - G.S3 V 217 G.S3.01
Hydrophobic TM3 L 245 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 324 5x64 G.H5 L 388 G.H5.20
Polar TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 342 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 325 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 321 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM7 Y 392 7x57 G.H5 Y 391 G.H5.23
Hydrophobic C-term L 462 - G.H3 W 281 G.H3.17
Van-der-waals C-term L 462 - G.H3 W 281 G.H3.17
Hydrophobic TM6 L 349 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 321 5x61 G.H5 L 393 G.H5.25
Polar TM5 R 328 5x68 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 R 328 5x68 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM5 R 328 5x68 G.h4s6 G 355 G.h4s6.11
Polar TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Ionic C-term E 461 - G.H5 R 389 G.H5.21
Hydrophobic TM3 L 245 3x58 G.H5 L 388 G.H5.20
Ionic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 324 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 324 5x64 G.H5 D 381 G.H5.13
Polar ICL3 Q 329 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 Q 329 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 328 5x68 G.H5 R 385 G.H5.17
Hydrophobic C-term Y 465 - G.H5 Q 390 G.H5.22
Van-der-waals C-term Y 465 - G.H5 Q 390 G.H5.22
Polar C-term Y 465 - G.H5 R 389 G.H5.21
Van-der-waals C-term Y 465 - G.H5 R 389 G.H5.21
Hydrophobic ICL2 V 248 - G.H5 I 383 G.H5.15
Van-der-waals C-term A 458 - G.h3s5 R 283 G.h3s5.01
Ionic TM6 R 341 6x40 G.H5 E 392 G.H5.24
Polar TM6 R 341 6x40 G.H5 E 392 G.H5.24
Polar C-term P 454 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term P 454 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term P 454 - G.h3s5 R 283 G.h3s5.01
Polar C-term A 458 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term A 458 - G.h4s6 R 356 G.h4s6.12