Beta-arrestin-2 - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GLP-1 78.2
Beta-arrestin-2 77.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 258 - S16 Y 250 C.S16.03
Hydrophobic ICL2 S 258 - S16 Y 250 C.S16.03
Van-der-waals ICL2 S 258 - S16 Y 250 C.S16.03
Hydrophobic TM2 R 176 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 176 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 356 6x45 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 356 6x45 s5s6 L 72 N.s5s6.08
Polar TM6 S 352 6x41 s5s6 L 72 N.s5s6.08
Polar TM3 Y 250 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic H8 E 412 8x53 s20c L 408 C.s20c.18
Van-der-waals H8 E 412 8x53 s20c L 408 C.s20c.18
Polar TM2 C 174 2x44 s5s6 D 68 N.s5s6.04
Polar TM2 N 177 2x47 s20c C 409 C.s20c.19
Hydrophobic TM2 N 177 2x47 s20c C 409 C.s20c.19
Van-der-waals TM2 N 177 2x47 s20c C 409 C.s20c.19
Hydrophobic ICL1 H 171 12x49 s20c Q 407 C.s20c.17
Polar TM3 L 254 3x57 S5 Y 64 N.S5.12
Van-der-waals TM4 E 262 4x39 s8s9 D 136 N.s8s9.06
Polar TM3 L 255 3x58 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 259 - S16 Y 250 C.S16.03
Van-der-waals ICL2 V 259 - S16 Y 250 C.S16.03
Ionic H8 K 415 8x56 s20c D 406 C.s20c.16
Polar H8 K 415 8x56 s20c D 406 C.s20c.16
Hydrophobic H8 K 415 8x56 s20c D 406 C.s20c.16
Van-der-waals H8 K 415 8x56 s20c D 406 C.s20c.16
Hydrophobic ICL1 H 171 12x49 s20c L 408 C.s20c.18
Hydrophobic H8 E 408 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 E 408 8x49 s20c L 408 C.s20c.18
Polar H8 E 408 8x49 s20c C 409 C.s20c.19
Hydrophobic H8 E 408 8x49 s20c C 409 C.s20c.19
Van-der-waals H8 E 408 8x49 s20c C 409 C.s20c.19
Hydrophobic ICL1 H 171 12x49 s20c C 409 C.s20c.19
Van-der-waals ICL1 H 171 12x49 s20c C 409 C.s20c.19
Hydrophobic TM3 L 255 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 255 3x58 s5s6 L 69 N.s5s6.05
Polar TM4 Q 263 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 Q 263 4x40 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 Q 263 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 L 251 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 251 3x54 s5s6 L 69 N.s5s6.05
Polar TM5 N 338 5x68 S6 K 78 N.S6.03
Hydrophobic TM5 N 338 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 N 338 5x68 S6 K 78 N.S6.03
Hydrophobic H8 K 415 8x56 s20c L 408 C.s20c.18
Van-der-waals H8 K 415 8x56 s20c L 408 C.s20c.18
Hydrophobic H8 L 411 8x52 s20c L 408 C.s20c.18
Van-der-waals H8 L 411 8x52 s20c L 408 C.s20c.18
Hydrophobic ICL1 H 171 12x49 s20c D 406 C.s20c.16
Van-der-waals ICL1 H 171 12x49 s20c D 406 C.s20c.16
Van-der-waals TM5 K 334 5x64 S5 Y 64 N.S5.12
Hydrophobic TM2 C 174 2x44 s20c C 409 C.s20c.19
Van-der-waals TM2 C 174 2x44 s20c C 409 C.s20c.19
Hydrophobic TM4 E 262 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 E 262 4x39 s8s9 E 135 N.s8s9.05
Polar TM3 A 256 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 Y 402 7x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 402 7x57 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 254 3x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 254 3x57 s5s6 R 66 N.s5s6.02
Polar TM5 N 338 5x68 S6 R 77 N.S6.02
Hydrophobic TM5 N 338 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 N 338 5x68 S6 R 77 N.S6.02
Hydrophobic H8 L 411 8x52 s20c D 406 C.s20c.16
Van-der-waals ICL2 S 258 - S16 A 248 C.S16.01
Ionic TM4 E 262 4x39 s5s6 R 66 N.s5s6.02
Polar TM4 E 262 4x39 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 E 262 4x39 s5s6 R 66 N.s5s6.02
Van-der-waals TM4 E 262 4x39 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 V 331 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 V 331 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals ICL2 S 258 - S5 Y 64 N.S5.12
Hydrophobic TM5 A 337 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 A 337 5x67 S6 K 78 N.S6.03
Polar ICL1 L 172 12x50 s20c C 409 C.s20c.19
Hydrophobic ICL1 L 172 12x50 s20c C 409 C.s20c.19
Van-der-waals ICL1 L 172 12x50 s20c C 409 C.s20c.19
Hydrophobic TM5 K 334 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 334 5x64 S6 F 76 N.S6.01
Hydrophobic TM5 N 338 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 L 251 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 251 3x54 s5s6 L 72 N.s5s6.08
Ionic TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Polar TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Ionic TM4 E 262 4x39 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 A 337 5x67 s15s16 F 245 C.s15s16.03
Polar TM2 R 176 2x46 s20c C 409 C.s20c.19
Van-der-waals TM2 R 176 2x46 s20c C 409 C.s20c.19
Hydrophobic H8 N 406 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 K 334 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 334 5x64 s15s16 F 245 C.s15s16.03