S-arrestin - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GLP-1 77.3
S-arrestin 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 254 3x57 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 L 254 3x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 L 356 6x45 s5s6 I 79 N.s5s6.08
Polar TM5 A 337 5x67 S6 R 85 N.S6.03
Hydrophobic TM5 A 337 5x67 S6 R 85 N.S6.03
Van-der-waals TM5 A 337 5x67 S6 R 85 N.S6.03
Hydrophobic TM2 R 176 2x46 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 R 176 2x46 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 T 355 6x44 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 355 6x44 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 R 176 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 176 2x46 s5s6 V 78 N.s5s6.07
Polar ICL1 H 171 12x49 s20c R 398 C.s20c.17
Hydrophobic ICL1 H 171 12x49 s20c R 398 C.s20c.17
Van-der-waals ICL1 H 171 12x49 s20c R 398 C.s20c.17
Hydrophobic ICL2 V 259 - s17s18 R 295 C.s17s18.11
Hydrophobic TM2 H 180 2x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 H 180 2x50 s5s6 V 78 N.s5s6.07
Polar ICL2 S 258 - S16 Y 259 C.S16.03
Hydrophobic ICL2 S 258 - S16 Y 259 C.S16.03
Van-der-waals ICL2 S 258 - S16 Y 259 C.S16.03
Polar TM3 L 255 3x58 S5 Y 71 N.S5.12
Hydrophobic TM3 A 256 3x59 S16 D 257 C.S16.01
Van-der-waals TM3 A 256 3x59 S16 D 257 C.S16.01
Polar ICL2 S 258 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 S 258 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 S 258 - s8s9 K 145 N.s8s9.09
Van-der-waals TM3 L 255 3x58 s15s16 S 255 C.s15s16.04
Polar TM3 F 257 3x60 s8s9 K 145 N.s8s9.09
Polar TM5 K 334 5x64 s15s16 L 253 C.s15s16.02
Hydrophobic TM5 K 334 5x64 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 K 334 5x64 s15s16 L 253 C.s15s16.02
Polar TM5 N 338 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 N 338 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 N 338 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 I 330 5x60 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 E 408 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 E 408 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 V 259 - s17s18 G 296 C.s17s18.12
Polar TM5 K 334 5x64 s15s16 Y 254 C.s15s16.03
Aromatic TM5 K 334 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 334 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 334 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 Y 402 7x57 s5s6 I 79 N.s5s6.08
Hydrophobic TM4 E 262 4x39 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 E 262 4x39 s8s9 D 142 N.s8s9.06
Polar TM2 R 176 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 176 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 R 348 6x37 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 348 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 V 259 - S16 Y 259 C.S16.03
Van-der-waals ICL2 V 259 - S16 Y 259 C.S16.03
Hydrophobic TM7 Y 402 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 402 7x57 s5s6 V 78 N.s5s6.07