Beta-arrestin-1 - GLP-2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GLP-2 65.1
Beta-arrestin-1 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 22.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 361 5x57 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 364 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 365 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 365 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 389 6x44 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 V 389 6x44 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 390 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 R 210 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 365 5x61 s5s6 L 71 N.s5s6.08
Ionic ICL1 K 205 12x49 s20c D 402 C.s20c.12
Polar ICL1 K 205 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 205 12x49 s20c D 402 C.s20c.12
Hydrophobic TM5 K 368 5x64 S6 F 75 N.S6.01
Hydrophobic TM3 P 291 3x60 s15s16 T 246 C.s15s16.05
Van-der-waals TM3 P 291 3x60 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 P 295 - s8s9 T 136 N.s8s9.07
Hydrophobic TM3 P 291 3x60 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 P 291 3x60 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 E 296 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 E 296 - s8s9 T 136 N.s8s9.07
Polar TM2 C 208 2x44 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 C 208 2x44 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 C 208 2x44 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 V 389 6x44 s5s6 L 71 N.s5s6.08
Polar ICL3 H 372 - S6 R 76 N.S6.02
Hydrophobic ICL3 H 372 - S6 R 76 N.S6.02
Van-der-waals ICL3 H 372 - S6 R 76 N.S6.02
Ionic H8 E 442 8x49 s8s9 K 138 N.s8s9.09
Polar H8 E 442 8x49 s8s9 K 138 N.s8s9.09
Van-der-waals H8 E 442 8x49 s8s9 K 138 N.s8s9.09
Polar TM2 N 211 2x47 s5s6 E 66 N.s5s6.03
Hydrophobic TM5 L 369 5x65 s5s6 L 73 N.s5s6.10
Ionic ICL2 R 297 - s8s9 E 134 N.s8s9.05
Polar ICL2 R 297 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 297 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 297 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL3 H 372 - S6 K 77 N.S6.03
Polar H8 K 449 8x56 s20c K 403 C.s20c.13
Hydrophobic TM3 L 288 3x57 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 L 288 3x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 L 289 3x58 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 386 6x41 s5s6 L 73 N.s5s6.10
Polar TM3 L 288 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 L 288 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 L 288 3x57 s5s6 R 65 N.s5s6.02
Ionic TM6 D 378 6x33 s9s10 K 157 N.s9s10.09
Polar TM6 D 378 6x33 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 D 378 6x33 s9s10 K 157 N.s9s10.09
Hydrophobic TM5 K 368 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 368 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 386 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 386 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic H8 E 442 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 E 442 8x49 s5s6 E 66 N.s5s6.03
Polar TM7 Q 435 7x56 s5s6 V 70 N.s5s6.07
Ionic ICL3 H 372 - S6 D 78 N.S6.04
Polar ICL3 H 372 - S6 D 78 N.S6.04
Hydrophobic ICL3 H 372 - S6 D 78 N.S6.04
Van-der-waals ICL3 H 372 - S6 D 78 N.S6.04
Hydrophobic TM2 R 210 2x46 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 Y 436 7x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 436 7x57 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 L 285 3x54 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 L 289 3x58 s5s6 L 68 N.s5s6.05
Ionic TM2 R 210 2x46 s5s6 E 66 N.s5s6.03
Polar TM2 R 210 2x46 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 R 210 2x46 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 R 210 2x46 s5s6 E 66 N.s5s6.03