Beta-arrestin-2 - glucagon receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
glucagon 79.1
Beta-arrestin-2 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 A 256 - S5 Y 64 N.S5.12
Hydrophobic ICL2 A 256 - S5 Y 64 N.S5.12
Van-der-waals ICL2 A 256 - S5 Y 64 N.S5.12
Hydrophobic TM5 K 332 5x64 S5 Y 64 N.S5.12
Van-der-waals TM5 K 332 5x64 S5 Y 64 N.S5.12
Hydrophobic TM3 L 253 3x58 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 253 3x58 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 T 257 - S8 L 130 N.S8.03
Van-der-waals ICL2 T 257 - S8 L 130 N.S8.03
Hydrophobic ICL2 T 257 - s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 T 257 - s17s18 G 287 C.s17s18.12
Hydrophobic ICL3 R 336 - S6 F 76 N.S6.01
Ionic TM2 R 173 2x46 s5s6 D 68 N.s5s6.04
Polar TM2 R 173 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 173 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 173 2x46 s5s6 D 68 N.s5s6.04
Ionic ICL1 K 168 12x49 s20c D 402 C.s20c.12
Polar ICL1 K 168 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 168 12x49 s20c D 402 C.s20c.12
Ionic H8 K 405 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 405 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 405 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 258 - s8s9 E 135 N.s8s9.05
Hydrophobic H8 N 404 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 Y 400 7x57 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 400 7x57 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 249 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 258 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 258 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 253 3x58 S6 F 76 N.S6.01
Hydrophobic TM5 K 332 5x64 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 K 332 5x64 s5s6 L 74 N.s5s6.10
Polar TM3 L 255 3x60 S5 Y 64 N.S5.12
Van-der-waals TM3 L 255 3x60 S5 Y 64 N.S5.12
Hydrophobic H8 S 409 8x52 s20c L 408 C.s20c.18
Polar ICL3 R 336 - S6 R 77 N.S6.02
Hydrophobic ICL3 R 336 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 336 - S6 R 77 N.S6.02
Polar TM2 C 171 2x44 s20c C 409 C.s20c.19
Hydrophobic TM2 C 171 2x44 s20c C 409 C.s20c.19
Van-der-waals TM2 C 171 2x44 s20c C 409 C.s20c.19
Hydrophobic TM3 L 252 3x57 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 252 3x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 256 - S16 A 248 C.S16.01
Van-der-waals ICL2 A 256 - S16 A 248 C.S16.01
Polar TM3 Y 248 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 249 3x54 s5s6 L 72 N.s5s6.08
Aromatic TM5 K 332 5x64 S6 F 76 N.S6.01
Hydrophobic TM5 K 332 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 332 5x64 S6 F 76 N.S6.01
Polar ICL3 R 336 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL3 R 336 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL3 R 336 - s5s6 S 75 N.s5s6.11
Polar ICL2 T 257 - S16 Y 250 C.S16.03
Hydrophobic ICL2 T 257 - S16 Y 250 C.S16.03
Van-der-waals ICL2 T 257 - S16 Y 250 C.S16.03
Ionic H8 R 413 8x56 s20c D 406 C.s20c.16
Polar H8 R 413 8x56 s20c D 406 C.s20c.16
Hydrophobic H8 R 413 8x56 s20c D 406 C.s20c.16
Van-der-waals H8 R 413 8x56 s20c D 406 C.s20c.16
Hydrophobic TM6 L 354 6x45 s5s6 L 72 N.s5s6.08
Polar TM2 N 174 2x47 s20c C 409 C.s20c.19
Hydrophobic TM2 N 174 2x47 s20c C 409 C.s20c.19
Van-der-waals TM2 N 174 2x47 s20c C 409 C.s20c.19
Hydrophobic ICL2 A 256 - s15s16 S 246 C.s15s16.04
Hydrophobic TM3 L 252 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 252 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 H 339 - S6 I 82 N.S6.07
Van-der-waals ICL3 H 339 - S6 I 82 N.S6.07
Polar TM3 L 253 3x58 S5 Y 64 N.S5.12
Hydrophobic H8 E 406 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 E 406 8x49 s20c L 408 C.s20c.18
Polar TM3 Y 248 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 A 335 5x67 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 335 5x67 s15s16 F 245 C.s15s16.03
Polar TM2 R 173 2x46 s20c C 409 C.s20c.19
Hydrophobic TM2 R 173 2x46 s20c C 409 C.s20c.19
Van-der-waals TM2 R 173 2x46 s20c C 409 C.s20c.19
Polar ICL2 A 256 - S16 Y 250 C.S16.03
Hydrophobic ICL2 A 256 - S16 Y 250 C.S16.03
Van-der-waals ICL2 A 256 - S16 Y 250 C.S16.03
Hydrophobic TM2 R 173 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 173 2x46 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 328 5x60 S6 F 76 N.S6.01
Van-der-waals TM5 L 328 5x60 S6 F 76 N.S6.01
Hydrophobic ICL1 K 168 12x49 s20c L 408 C.s20c.18
Hydrophobic ICL2 L 258 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 L 258 - s8s9 D 136 N.s8s9.06
Polar TM6 S 350 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 350 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 329 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 329 5x61 s5s6 L 74 N.s5s6.10
Polar TM3 G 254 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 G 254 3x59 s15s16 S 246 C.s15s16.04
Hydrophobic H8 E 410 8x53 s20c L 408 C.s20c.18
Hydrophobic TM5 K 332 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 A 256 - S15 I 242 C.S15.14
Van-der-waals ICL2 A 256 - S15 I 242 C.S15.14
Polar ICL1 H 170 12x51 s20c C 409 C.s20c.19
Hydrophobic ICL1 H 170 12x51 s20c C 409 C.s20c.19
Van-der-waals ICL1 H 170 12x51 s20c C 409 C.s20c.19
Polar ICL1 L 169 12x50 s20c C 409 C.s20c.19
Hydrophobic ICL1 L 169 12x50 s20c C 409 C.s20c.19
Van-der-waals ICL1 L 169 12x50 s20c C 409 C.s20c.19
Polar TM2 R 173 2x46 s20c L 408 C.s20c.18
Polar ICL1 K 168 12x49 s20c C 409 C.s20c.19
Hydrophobic ICL1 K 168 12x49 s20c C 409 C.s20c.19
Van-der-waals ICL1 K 168 12x49 s20c C 409 C.s20c.19