Arrestin-C - glucagon receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
glucagon 77.7
Arrestin-C 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 325 5x57 s5s6 I 67 N.s5s6.08
Ionic H8 R 412 8x55 s20c E 383 C.s20c.17
Polar H8 R 412 8x55 s20c E 383 C.s20c.17
Hydrophobic H8 R 412 8x55 s20c E 383 C.s20c.17
Van-der-waals H8 R 412 8x55 s20c E 383 C.s20c.17
Hydrophobic TM3 L 252 3x57 s5s6 D 62 N.s5s6.03
Polar H8 H 416 8x59 s20c A 379 C.s20c.12
Hydrophobic H8 H 416 8x59 s20c A 379 C.s20c.12
Hydrophobic TM6 L 357 6x48 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 L 357 6x48 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 L 354 6x45 s5s6 I 67 N.s5s6.08
Polar ICL2 A 256 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 256 - s5s6 R 61 N.s5s6.02
Hydrophobic TM5 L 329 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 L 329 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 329 5x61 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 S 350 6x41 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 S 350 6x41 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 249 3x54 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 249 3x54 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 L 253 3x58 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 258 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 L 258 - s8s9 A 133 N.s8s9.07
Hydrophobic TM5 L 329 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 329 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 L 252 3x57 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 252 3x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 L 249 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 253 3x58 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 L 253 3x58 s5s6 D 63 N.s5s6.04
Polar TM3 L 252 3x57 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 L 252 3x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 H 339 - S6 V 77 N.S6.07
Hydrophobic TM5 L 333 5x65 s5s6 L 69 N.s5s6.10
Polar ICL3 R 336 - S6 R 72 N.S6.02
Hydrophobic ICL3 R 336 - S6 R 72 N.S6.02
Van-der-waals ICL3 R 336 - S6 R 72 N.S6.02
Ionic TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Polar TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 R 173 2x46 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 H 177 2x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 L 249 3x54 s5s6 V 66 N.s5s6.07
Ionic ICL3 H 340 - S6 D 74 N.S6.04
Polar ICL3 H 340 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 336 - S6 K 73 N.S6.03
Van-der-waals ICL3 R 336 - S6 K 73 N.S6.03
Polar ICL3 R 336 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 R 336 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 R 336 - s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 L 253 3x58 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 R 346 6x37 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 258 - s8s9 G 134 N.s8s9.08
Ionic TM2 R 173 2x46 s5s6 E 65 N.s5s6.06
Polar TM2 R 173 2x46 s5s6 E 65 N.s5s6.06
Polar ICL3 R 336 - S6 F 71 N.S6.01
Aromatic ICL3 R 336 - S6 F 71 N.S6.01
Hydrophobic ICL3 R 336 - S6 F 71 N.S6.01
Van-der-waals ICL3 R 336 - S6 F 71 N.S6.01
Ionic H8 H 416 8x59 s20c E 383 C.s20c.17
Polar H8 H 416 8x59 s20c E 383 C.s20c.17
Hydrophobic H8 H 416 8x59 s20c E 383 C.s20c.17
Van-der-waals H8 H 416 8x59 s20c E 383 C.s20c.17
Hydrophobic TM2 R 173 2x46 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 R 173 2x46 s5s6 V 66 N.s5s6.07
Polar TM7 Y 400 7x57 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 Y 400 7x57 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 400 7x57 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 K 332 5x64 S6 F 71 N.S6.01
Van-der-waals TM5 K 332 5x64 S6 F 71 N.S6.01
Polar TM3 L 255 3x60 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 L 255 3x60 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 S 350 6x41 s5s6 L 69 N.s5s6.10