Beta-arrestin-2 - GnRH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GnRH1 72.9
Beta-arrestin-2 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 s15s16 S 246 C.s15s16.04
Polar TM6 Q 253 6x21 S6 L 80 N.S6.05
Hydrophobic TM6 Q 253 6x21 S6 L 80 N.S6.05
Polar ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 147 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 147 34x51 s15s16 S 246 C.s15s16.04
Polar ICL2 S 151 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 S 151 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL3 L 249 - S6 K 78 N.S6.03
Polar ICL1 K 71 12x48 s20c Y 404 C.s20c.14
Aromatic ICL1 K 71 12x48 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 71 12x48 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 71 12x48 s20c Y 404 C.s20c.14
Hydrophobic ICL3 L 249 - s17s18 E 314 C.s17s18.39
Polar TM2 R 75 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 75 2x38 s5s6 D 68 N.s5s6.04
Polar TM6 T 265 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 265 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 265 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 251 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 L 251 - s17s18 V 315 C.s17s18.40
Polar ICL2 S 151 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 S 151 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 S 151 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 147 34x51 S9 C 141 N.S9.01
Polar TM6 T 265 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 265 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 265 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 249 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 L 249 - s17s18 V 315 C.s17s18.40
Hydrophobic ICL3 L 249 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 L 249 - s17s18 N 312 C.s17s18.37
Aromatic TM6 R 262 6x30 S6 F 76 N.S6.01
Hydrophobic TM6 R 262 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 R 262 6x30 S6 F 76 N.S6.01
Hydrophobic ICL2 L 147 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 147 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 147 34x51 S8 L 130 N.S8.03
Hydrophobic TM6 S 254 6x22 S6 I 82 N.S6.07
Hydrophobic TM6 R 262 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 N 252 - S6 L 80 N.S6.05
Hydrophobic TM6 P 259 6x27 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 P 259 6x27 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 I 143 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 143 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 M 76 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 M 76 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 P 146 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 146 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 146 34x50 S5 Y 64 N.S5.12
Polar TM4 S 153 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 153 4x39 s8s9 E 135 N.s8s9.05
Polar ICL1 K 71 12x48 s20c D 403 C.s20c.13
Hydrophobic ICL1 K 71 12x48 s20c D 403 C.s20c.13
Van-der-waals ICL1 K 71 12x48 s20c D 403 C.s20c.13
Hydrophobic TM5 V 241 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 241 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 261 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 A 261 6x29 s5s6 G 73 N.s5s6.09
Polar TM5 Q 244 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 Q 244 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 L 251 - s7s8 L 124 N.s7s8.06
Van-der-waals ICL3 L 251 - s7s8 L 124 N.s7s8.06
Hydrophobic ICL1 S 74 12x51 s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 S 74 12x51 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 143 3x54 S6 F 76 N.S6.01
Polar TM6 S 254 6x22 S6 D 79 N.S6.04
Hydrophobic TM6 S 254 6x22 S6 D 79 N.S6.04
Van-der-waals TM6 S 254 6x22 S6 D 79 N.S6.04
Hydrophobic TM6 P 259 6x27 S6 R 77 N.S6.02
Van-der-waals TM6 P 259 6x27 S6 R 77 N.S6.02
Hydrophobic ICL3 L 251 - s7s8 N 123 N.s7s8.05
Polar ICL2 S 151 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 S 151 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 S 151 - s8s9 D 136 N.s8s9.06
Polar TM6 R 262 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 262 6x30 s5s6 G 73 N.s5s6.09
Polar TM6 T 265 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 T 265 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic ICL1 S 74 12x51 s5s6 V 71 N.s5s6.07
Polar ICL2 K 150 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 150 - s5s6 R 66 N.s5s6.02
Polar ICL2 L 147 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 147 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 147 34x51 S5 Y 64 N.S5.12
Polar ICL2 L 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 149 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 149 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 147 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 147 34x51 S15 I 242 C.S15.14
Aromatic TM6 R 262 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 R 262 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 R 262 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 M 76 2x39 s5s6 V 71 N.s5s6.07
Polar TM6 Q 253 6x21 S6 K 78 N.S6.03
Hydrophobic TM6 Q 253 6x21 S6 K 78 N.S6.03
Van-der-waals TM6 Q 253 6x21 S6 K 78 N.S6.03