Beta-arrestin-2 - GPR101 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR101 75.8
Beta-arrestin-2 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 226 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 L 226 5x72 S6 R 77 N.S6.02
Hydrophobic TM6 A 397 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 397 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 133 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 133 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 140 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 140 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic H8 T 460 8x49 s5s6 E 67 N.s5s6.03
Polar TM4 Q 145 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 Q 145 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 Q 145 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 K 230 - S6 I 82 N.S6.07
Van-der-waals ICL3 K 230 - S6 I 82 N.S6.07
Hydrophobic TM5 V 229 5x75 S6 D 79 N.S6.04
Van-der-waals TM5 V 229 5x75 S6 D 79 N.S6.04
Hydrophobic TM5 Q 222 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 222 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 225 5x71 S6 K 78 N.S6.03
Hydrophobic ICL2 L 137 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 L 137 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 P 136 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic TM3 R 129 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 129 3x50 s5s6 V 71 N.s5s6.07
Polar TM2 Q 64 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 Q 64 2x37 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 Q 64 2x37 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 136 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 226 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 L 226 5x72 S6 K 78 N.S6.03
Hydrophobic TM6 V 400 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 400 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 133 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 133 3x54 s5s6 L 69 N.s5s6.05
Polar ICL1 Q 61 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 Q 61 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 Q 61 12x49 s20c D 402 C.s20c.12
Polar TM1 K 59 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM1 K 59 1x60 s20c Y 404 C.s20c.14
Van-der-waals TM1 K 59 1x60 s20c Y 404 C.s20c.14
Ionic ICL3 K 230 - S6 D 79 N.S6.04
Hydrophobic TM5 Y 212 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Y 139 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 139 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 K 396 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 V 229 5x75 S6 L 80 N.S6.05
Van-der-waals TM5 V 229 5x75 S6 L 80 N.S6.05
Polar TM2 Q 64 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 Q 64 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 Q 64 2x37 s5s6 D 68 N.s5s6.04
Polar ICL2 S 138 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 S 138 34x52 S16 Y 250 C.S16.03
Hydrophobic TM5 V 215 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 229 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 V 229 5x75 S6 K 78 N.S6.03
Hydrophobic TM5 L 226 5x72 S6 D 79 N.S6.04
Van-der-waals TM5 L 226 5x72 S6 D 79 N.S6.04
Hydrophobic ICL2 P 140 34x54 s8s9 D 136 N.s8s9.06
Ionic H8 K 459 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 459 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 459 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 459 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 137 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 L 137 34x51 S8 L 130 N.S8.03
Hydrophobic ICL1 Q 61 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 Q 61 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 L 137 34x51 S5 Y 64 N.S5.12
Polar TM2 Q 64 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 Q 64 2x37 s8s9 T 137 N.s8s9.07
Polar ICL2 P 136 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 136 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 136 34x50 S5 Y 64 N.S5.12
Polar TM3 R 129 3x50 s5s6 D 68 N.s5s6.04
Polar ICL3 R 381 - S6 T 84 N.S6.09
Hydrophobic TM6 I 401 6x37 s5s6 L 72 N.s5s6.08
Polar H8 E 464 8x53 s20c Y 404 C.s20c.14
Hydrophobic TM5 V 215 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 V 215 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 133 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 133 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 137 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 137 34x51 S15 I 242 C.S15.14
Polar TM3 I 134 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic H8 H 458 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 H 458 8x47 s5s6 V 71 N.s5s6.07
Polar TM6 Y 393 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 Y 393 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Y 393 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 A 219 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 219 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 I 404 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 S 132 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 132 3x53 s5s6 L 69 N.s5s6.05
Polar TM5 Q 222 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 Q 222 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 Q 222 5x68 S6 F 76 N.S6.01
Polar ICL1 Q 61 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 Q 61 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 Q 61 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 137 34x51 S16 Y 250 C.S16.03
Polar ICL2 L 137 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 137 34x51 S16 Y 250 C.S16.03