ArrestinDb

S-arrestin - GPR101 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR101	73.8
S-arrestin	79.7

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 20.4

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	ICL2	L	137	34x51	S9	C	147	N.S9.01
Hydrophobic	TM6	A	397	6x33	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	L	226	5x72	S6	L	87	N.S6.05
Hydrophobic	H8	H	458	8x47	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL3	K	230	-	S6	F	89	N.S6.07
Hydrophobic	TM6	A	397	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	L	137	34x51	S16	Y	259	C.S16.03
Hydrophobic	TM2	Q	64	2x37	s5s6	Q	73	N.s5s6.02
Hydrophobic	TM6	I	404	6x40	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	V	229	5x75	s7s8	Y	129	N.s7s8.05
Hydrophobic	H8	H	458	8x47	s5s6	D	77	N.s5s6.06
Hydrophobic	ICL2	P	136	34x50	S5	Y	71	N.S5.12
Hydrophobic	ICL2	P	140	34x54	s8s9	D	142	N.s8s9.06
Hydrophobic	TM3	I	133	3x54	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	P	136	34x50	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL2	Y	139	34x53	s8s9	K	145	N.s8s9.09
Hydrophobic	TM5	Q	222	5x68	S6	R	85	N.S6.03
Hydrophobic	TM5	V	215	5x61	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL1	L	62	12x50	s5s6	D	75	N.s5s6.04
Hydrophobic	TM6	V	400	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	L	225	5x71	s17s18	V	324	C.s17s18.40
Hydrophobic	ICL2	L	137	34x51	S15	V	251	C.S15.14
Hydrophobic	TM5	A	219	5x65	s5s6	L	81	N.s5s6.10
Hydrophobic	TM3	I	134	3x55	s15s16	S	255	C.s15s16.04
Hydrophobic	TM5	V	229	5x75	S6	L	87	N.S6.05
Hydrophobic	TM3	H	135	3x56	S16	D	257	C.S16.01
Hydrophobic	TM5	L	226	5x72	S6	R	85	N.S6.03
Hydrophobic	ICL2	L	137	34x51	S8	L	136	N.S8.03
Hydrophobic	TM5	L	226	5x72	S6	D	86	N.S6.04
Hydrophobic	TM6	I	401	6x37	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	K	396	6x32	s5s6	G	80	N.s5s6.09
Hydrophobic	TM5	Y	212	5x58	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	P	140	34x54	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL3	S	233	-	S6	Y	88	N.S6.06
Hydrophobic	ICL2	L	137	34x51	S5	Y	71	N.S5.12
Hydrophobic	TM5	L	225	5x71	S6	R	85	N.S6.03
Hydrophobic	TM5	Q	222	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM5	V	215	5x61	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	S	138	34x52	S16	D	257	C.S16.01
Hydrophobic	TM3	H	135	3x56	s15s16	S	255	C.s15s16.04
Hydrophobic	TM3	R	129	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	TM3	I	133	3x54	S6	F	83	N.S6.01
Hydrophobic	TM5	V	229	5x75	s17s18	V	324	C.s17s18.40
Hydrophobic	ICL2	S	138	34x52	S16	Y	259	C.S16.03
Hydrophobic	H8	K	459	8x48	s5s6	D	77	N.s5s6.06
Hydrophobic	H8	T	460	8x49	s5s6	D	75	N.s5s6.04
Hydrophobic	TM6	Y	393	6x29	s5s6	L	81	N.s5s6.10
Ionic	ICL2	K	142	34x56	S16	D	257	C.S16.01
Ionic	H8	K	459	8x48	s9s10	D	166	N.s9s10.08
Ionic	TM6	K	396	6x32	s5s6	D	77	N.s5s6.06
Ionic	TM3	H	135	3x56	S16	D	257	C.S16.01
Polar	ICL1	Q	61	12x49	s20c	E	395	C.s20c.14
Polar	TM6	Y	393	6x29	s5s6	T	82	N.s5s6.11
Polar	ICL2	L	137	34x51	S16	Y	259	C.S16.03
Polar	TM2	Q	64	2x37	s5s6	Q	73	N.s5s6.02
Polar	H8	H	458	8x47	s5s6	D	77	N.s5s6.06
Polar	ICL2	P	136	34x50	S5	Y	71	N.S5.12
Polar	TM5	Q	222	5x68	S6	R	85	N.S6.03
Polar	TM5	Q	222	5x68	S6	R	84	N.S6.02
Polar	ICL1	Q	61	12x49	s5s6	Q	73	N.s5s6.02
Polar	TM3	I	134	3x55	s15s16	S	255	C.s15s16.04
Polar	TM3	H	135	3x56	S16	D	257	C.S16.01
Polar	TM6	K	396	6x32	s5s6	G	80	N.s5s6.09
Polar	ICL2	P	136	34x50	S16	D	257	C.S16.01
Polar	ICL2	L	137	34x51	S5	Y	71	N.S5.12
Polar	H8	H	458	8x47	s5s6	I	79	N.s5s6.08
Polar	TM5	Q	222	5x68	s15s16	Y	254	C.s15s16.03
Polar	ICL2	S	138	34x52	S16	D	257	C.S16.01
Polar	ICL2	S	138	34x52	S16	Y	259	C.S16.03
Polar	H8	K	459	8x48	s5s6	D	77	N.s5s6.06
Polar	H8	T	460	8x49	s5s6	D	75	N.s5s6.04
Van-der-waals	TM6	Y	393	6x29	s5s6	T	82	N.s5s6.11
Van-der-waals	ICL2	L	137	34x51	S9	C	147	N.S9.01
Van-der-waals	H8	H	458	8x47	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL2	L	137	34x51	S16	Y	259	C.S16.03
Van-der-waals	TM2	Q	64	2x37	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM5	V	229	5x75	s7s8	Y	129	N.s7s8.05
Van-der-waals	H8	H	458	8x47	s5s6	D	77	N.s5s6.06
Van-der-waals	ICL2	P	136	34x50	S5	Y	71	N.S5.12
Van-der-waals	ICL2	P	140	34x54	s8s9	D	142	N.s8s9.06
Van-der-waals	ICL2	P	136	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	Y	139	34x53	s8s9	K	145	N.s8s9.09
Van-der-waals	TM5	Q	222	5x68	S6	R	85	N.S6.03
Van-der-waals	TM5	Q	222	5x68	S6	R	84	N.S6.02
Van-der-waals	TM6	V	400	6x36	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL1	Q	61	12x49	s5s6	Q	73	N.s5s6.02
Van-der-waals	ICL2	L	137	34x51	S15	V	251	C.S15.14
Van-der-waals	TM3	I	134	3x55	s15s16	S	255	C.s15s16.04
Van-der-waals	TM5	V	229	5x75	S6	L	87	N.S6.05
Van-der-waals	TM3	H	135	3x56	S16	D	257	C.S16.01
Van-der-waals	TM5	L	226	5x72	S6	R	85	N.S6.03
Van-der-waals	TM3	I	134	3x55	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	L	137	34x51	S8	L	136	N.S8.03
Van-der-waals	TM5	L	226	5x72	S6	D	86	N.S6.04
Van-der-waals	TM6	K	396	6x32	s5s6	G	80	N.s5s6.09
Van-der-waals	TM5	Y	212	5x58	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	P	140	34x54	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	L	137	34x51	S5	Y	71	N.S5.12
Van-der-waals	H8	H	458	8x47	s5s6	I	79	N.s5s6.08
Van-der-waals	TM5	L	225	5x71	S6	R	85	N.S6.03
Van-der-waals	TM5	Q	222	5x68	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	S	138	34x52	S16	D	257	C.S16.01
Van-der-waals	TM3	R	129	3x50	s5s6	V	78	N.s5s6.07
Van-der-waals	TM3	I	133	3x54	S6	F	83	N.S6.01
Van-der-waals	ICL2	S	138	34x52	S16	Y	259	C.S16.03
Van-der-waals	H8	K	459	8x48	s5s6	D	77	N.s5s6.06
Van-der-waals	H8	T	460	8x49	s5s6	D	75	N.s5s6.04

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Main reference

S-arrestin - GPR101 complex model Download Full