Beta-arrestin-1 - GPR119 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR119 82.1
Beta-arrestin-1 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 199 5x73 S6 K 77 N.S6.03
Hydrophobic ICL2 R 112 34x52 s8s9 D 135 N.s8s9.06
Hydrophobic TM5 H 195 5x69 S6 F 75 N.S6.01
Van-der-waals TM5 H 195 5x69 S6 F 75 N.S6.01
Hydrophobic H8 L 288 8x52 s20c E 407 C.s20c.17
Hydrophobic TM5 M 188 5x62 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 111 34x51 S8 L 129 N.S8.03
Polar ICL2 F 111 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 F 111 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 F 111 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 A 192 5x66 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 192 5x66 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 M 202 5x76 S6 K 77 N.S6.03
Van-der-waals TM5 M 202 5x76 S6 K 77 N.S6.03
Polar ICL2 P 110 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 110 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 110 34x50 S5 Y 63 N.S5.12
Ionic H8 K 284 8x48 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 R 103 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 107 3x54 S6 F 75 N.S6.01
Van-der-waals ICL2 L 114 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic H8 E 285 8x49 s5s6 D 67 N.s5s6.04
Polar ICL3 Y 212 - S6 N 83 N.S6.09
Hydrophobic ICL3 Y 212 - S6 N 83 N.S6.09
Van-der-waals ICL3 Y 212 - S6 N 83 N.S6.09
Hydrophobic ICL2 F 111 34x51 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 F 111 34x51 s8s9 G 137 N.s8s9.08
Polar ICL2 Y 113 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 Y 113 34x53 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 Y 113 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 L 114 34x54 s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 L 114 34x54 s8s9 P 133 N.s8s9.04
Hydrophobic TM5 I 199 5x73 s15s16 F 244 C.s15s16.03
Ionic TM6 R 216 6x26 s9s10 E 155 N.s9s10.07
Polar TM6 R 216 6x26 s9s10 E 155 N.s9s10.07
Hydrophobic TM6 R 216 6x26 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 R 216 6x26 s9s10 E 155 N.s9s10.07
Polar ICL2 L 114 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 L 114 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 L 114 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 Y 113 34x53 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Y 113 34x53 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Y 113 34x53 s8s9 T 136 N.s8s9.07
Polar ICL2 P 110 34x50 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 P 110 34x50 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 P 110 34x50 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 L 114 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 L 114 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic TM5 M 202 5x76 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 M 202 5x76 s17s18 I 314 C.s17s18.40
Hydrophobic ICL3 Y 212 - S6 A 82 N.S6.08
Van-der-waals ICL3 Y 212 - S6 A 82 N.S6.08
Hydrophobic ICL2 F 111 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 111 34x51 S15 I 241 C.S15.14
Hydrophobic TM6 T 226 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 226 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 114 34x54 s8s9 G 132 N.s8s9.03
Van-der-waals ICL2 L 114 34x54 s8s9 G 132 N.s8s9.03
Hydrophobic TM5 I 199 5x73 S6 R 76 N.S6.02
Hydrophobic ICL3 Y 212 - S6 V 81 N.S6.07
Van-der-waals ICL3 Y 212 - S6 V 81 N.S6.07
Polar ICL2 K 115 34x55 s8s9 D 135 N.s8s9.06
Polar TM5 Q 198 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 Q 198 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 Q 198 5x72 S6 K 77 N.S6.03
Polar ICL2 K 115 34x55 s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 K 115 34x55 s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 K 115 34x55 s8s9 P 133 N.s8s9.04
Polar TM5 Q 198 5x72 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 Q 198 5x72 s17s18 E 313 C.s17s18.39
Ionic TM6 K 222 6x32 s5s6 D 69 N.s5s6.06
Polar TM5 Q 198 5x72 s15s16 F 244 C.s15s16.03
Polar TM5 H 195 5x69 s15s16 F 244 C.s15s16.03
Aromatic TM5 H 195 5x69 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 195 5x69 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 195 5x69 s15s16 F 244 C.s15s16.03
Aromatic ICL2 F 111 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 F 111 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 111 34x51 S16 Y 249 C.S16.03
Polar ICL2 R 112 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 112 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 112 34x52 s8s9 T 136 N.s8s9.07
Ionic TM6 R 213 6x23 s9s10 E 155 N.s9s10.07
Polar TM6 R 213 6x23 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 R 213 6x23 s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 P 110 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 110 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 V 227 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 227 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 111 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 111 34x51 S5 Y 63 N.S5.12
Polar TM3 Q 109 3x56 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 Q 109 3x56 s8s9 T 136 N.s8s9.07
Van-der-waals TM3 Q 109 3x56 s8s9 T 136 N.s8s9.07
Ionic ICL2 K 115 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 K 115 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 K 115 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 K 115 34x55 s8s9 E 134 N.s8s9.05
Polar TM6 K 222 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 K 222 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 222 6x32 s5s6 G 72 N.s5s6.09
Polar TM3 A 106 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 A 106 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 A 106 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 F 111 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 F 111 34x51 S16 A 247 C.S16.01
Hydrophobic TM5 Q 198 5x72 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 Y 185 5x59 s5s6 L 71 N.s5s6.08
Polar TM2 S 40 2x39 s5s6 D 67 N.s5s6.04
Polar TM2 S 40 2x39 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 A 223 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 P 110 34x50 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 110 34x50 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 P 110 34x50 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 I 107 3x54 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 I 107 3x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 F 111 34x51 s8s9 D 135 N.s8s9.06
Polar TM6 T 226 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 226 6x36 s5s6 L 71 N.s5s6.08