G14 - GPR119 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR119 85.3
subunit alpha-14 88.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
01
iPTM Score: 0.8
01
PAE mean: 11.9
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
K52G.HNR02G.hns1F08Q17E22L25G.H5GproteinD-S2x39H5x69A6x33F34x51GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.hns1G.H5GPCR segments:ICL1TM2ICL2TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x393x503x533x5434x5034x5134x5434x554x385x625x655x665x695x736x236x256x326x336x366x377x56G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.h4s6.20G.h4s6.11G.H4.17G.H4.13G.S3.03G.S3.01G.s2s3.02G.S1.02G.hns1.03G.hns1.02G.HN.52G.HN.48Res. Pos.GPR119 (AFM_GP119_HUMAN_GNA14_HUMAN)- (AFM_GP119_HUMAN_GNA14_HUMAN)-----------------------GSRAIPFLKSMIAHIRPKATVWGSPFLKRAISMIAHIRPKATVWAREKIFVLIFNFNLLLRDQVKNVKDRK

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.