S-arrestin - GPR135 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR135 53.6
S-arrestin 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 F 324 6x28 S6 R 84 N.S6.02
Van-der-waals TM6 F 324 6x28 S6 R 84 N.S6.02
Hydrophobic H8 M 396 8x52 s15s16 S 256 C.s15s16.05
Van-der-waals H8 M 396 8x52 s15s16 S 256 C.s15s16.05
Hydrophobic C-term L 415 - s17s18 R 294 C.s17s18.10
Van-der-waals C-term L 415 - s17s18 R 294 C.s17s18.10
Hydrophobic ICL3 P 313 - S6 F 89 N.S6.07
Van-der-waals ICL3 P 313 - S6 F 89 N.S6.07
Ionic C-term R 437 - s19s20 E 370 C.s19s20.09
Polar C-term R 437 - s19s20 E 370 C.s19s20.09
Van-der-waals C-term R 437 - s19s20 E 370 C.s19s20.09
Hydrophobic TM5 V 304 5x65 S6 F 83 N.S6.01
Hydrophobic TM5 R 312 5x73 S6 F 89 N.S6.07
Hydrophobic TM6 V 327 6x31 S6 F 83 N.S6.01
Van-der-waals TM6 V 327 6x31 S6 F 83 N.S6.01
Hydrophobic C-term T 408 - S16 K 261 C.S16.05
Van-der-waals C-term T 408 - S16 K 261 C.S16.05
Ionic H8 R 402 8x58 S16 D 257 C.S16.01
Polar H8 R 402 8x58 S16 D 257 C.S16.01
Ionic C-term R 437 - s19s20 E 365 C.s19s20.04
Hydrophobic C-term R 437 - s19s20 E 365 C.s19s20.04
Van-der-waals C-term R 437 - s19s20 E 365 C.s19s20.04
Hydrophobic ICL3 Y 317 - s7s8 P 131 N.s7s8.07
Hydrophobic TM6 L 321 6x25 s17s18 V 324 C.s17s18.40
Hydrophobic C-term G 405 - S16 V 260 C.S16.04
Hydrophobic TM5 V 309 5x70 s9s10 E 165 N.s9s10.07
Hydrophobic ICL3 Y 317 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL3 Y 317 - s15s16 L 253 C.s15s16.02
Hydrophobic TM5 V 304 5x65 s5s6 G 80 N.s5s6.09
Polar ICL3 Y 317 - s17s18 V 324 C.s17s18.40
Hydrophobic ICL3 Y 317 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 Y 317 - s17s18 V 324 C.s17s18.40
Hydrophobic H8 P 392 8x48 s15s16 S 255 C.s15s16.04
Van-der-waals H8 P 392 8x48 s15s16 S 255 C.s15s16.04
Ionic C-term D 412 - S15 K 242 C.S15.05
Polar C-term D 412 - S15 K 242 C.S15.05
Van-der-waals C-term D 412 - S15 K 242 C.S15.05
Polar C-term Y 406 - S16 Y 258 C.S16.02
Van-der-waals C-term Y 406 - S16 Y 258 C.S16.02
Hydrophobic TM6 L 321 6x25 s15s16 L 253 C.s15s16.02
Polar TM6 V 320 6x24 S6 R 85 N.S6.03
Hydrophobic TM6 V 320 6x24 S6 R 85 N.S6.03
Van-der-waals TM6 V 320 6x24 S6 R 85 N.S6.03
Polar ICL3 N 315 - s7s8 Y 129 N.s7s8.05
Polar TM6 F 324 6x28 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 F 324 6x28 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 F 324 6x28 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 F 324 6x28 S6 F 83 N.S6.01
Van-der-waals TM6 F 324 6x28 S6 F 83 N.S6.01
Hydrophobic TM6 T 331 6x35 s5s6 L 81 N.s5s6.10
Aromatic C-term Y 406 - S16 Y 259 C.S16.03
Hydrophobic C-term Y 406 - S16 Y 259 C.S16.03
Van-der-waals C-term Y 406 - S16 Y 259 C.S16.03
Polar C-term Y 406 - S16 K 261 C.S16.05
Hydrophobic C-term Y 406 - S16 K 261 C.S16.05
Van-der-waals C-term Y 406 - S16 K 261 C.S16.05
Ionic TM5 R 310 5x71 s9s10 E 164 N.s9s10.06
Polar TM5 R 310 5x71 s9s10 E 164 N.s9s10.06
Hydrophobic TM5 R 310 5x71 s9s10 E 164 N.s9s10.06
Van-der-waals TM5 R 310 5x71 s9s10 E 164 N.s9s10.06
Polar ICL3 Y 317 - S6 R 85 N.S6.03
Aromatic ICL3 Y 317 - S6 R 85 N.S6.03
Hydrophobic ICL3 Y 317 - S6 R 85 N.S6.03
Van-der-waals ICL3 Y 317 - S6 R 85 N.S6.03
Hydrophobic C-term G 405 - S16 Y 258 C.S16.02
Van-der-waals C-term G 405 - S16 Y 258 C.S16.02
Hydrophobic C-term Y 406 - S16 V 260 C.S16.04
Van-der-waals C-term Y 406 - S16 V 260 C.S16.04
Hydrophobic TM5 V 311 5x72 S6 R 85 N.S6.03
Polar TM6 R 328 6x32 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 328 6x32 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 328 6x32 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 321 6x25 S6 R 85 N.S6.03
Van-der-waals TM6 L 321 6x25 S6 R 85 N.S6.03
Ionic TM5 R 310 5x71 s9s10 D 166 N.s9s10.08
Polar TM5 R 310 5x71 s9s10 D 166 N.s9s10.08
Van-der-waals TM5 R 310 5x71 s9s10 D 166 N.s9s10.08
Polar ICL3 Y 317 - s17s18 L 325 C.s17s18.41
Polar C-term R 407 - S16 V 260 C.S16.04
Hydrophobic C-term R 407 - S16 V 260 C.S16.04
Van-der-waals C-term R 407 - S16 V 260 C.S16.04
Hydrophobic TM6 L 321 6x25 s17s18 T 323 C.s17s18.39
Van-der-waals TM6 L 321 6x25 s17s18 T 323 C.s17s18.39
Polar C-term Y 406 - s8s9 D 142 N.s8s9.06
Van-der-waals C-term Y 406 - s8s9 D 142 N.s8s9.06
Polar TM5 D 308 5x69 S6 R 84 N.S6.02
Hydrophobic C-term Y 434 - s19s20 E 365 C.s19s20.04
Polar ICL3 Y 317 - s17s18 T 323 C.s17s18.39
Hydrophobic ICL3 Y 317 - s17s18 T 323 C.s17s18.39
Van-der-waals ICL3 Y 317 - s17s18 T 323 C.s17s18.39
Hydrophobic TM5 V 309 5x70 s9s10 D 166 N.s9s10.08
Van-der-waals TM5 V 309 5x70 s9s10 D 166 N.s9s10.08
Hydrophobic TM5 V 311 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 V 311 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 D 308 5x69 s5s6 T 82 N.s5s6.11
Hydrophobic C-term V 411 - S16 P 262 C.S16.06
Hydrophobic TM6 R 328 6x32 s15s16 S 255 C.s15s16.04
Van-der-waals TM6 R 328 6x32 s15s16 S 255 C.s15s16.04
Hydrophobic C-term T 408 - S16 P 262 C.S16.06
Van-der-waals C-term T 408 - S16 P 262 C.S16.06
Hydrophobic TM6 F 324 6x28 S6 R 85 N.S6.03
Van-der-waals TM6 F 324 6x28 S6 R 85 N.S6.03
Hydrophobic C-term V 411 - S15 F 244 C.S15.07
Van-der-waals C-term V 411 - S15 F 244 C.S15.07
Polar TM5 R 305 5x66 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 R 305 5x66 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 R 305 5x66 s5s6 I 79 N.s5s6.08
Polar ICL3 Y 317 - s17s18 G 326 C.s17s18.42
Hydrophobic C-term L 415 - S16 M 265 C.S16.09
Van-der-waals C-term L 415 - S16 M 265 C.S16.09
Ionic C-term R 407 - S19 E 354 C.S19.06
Hydrophobic ICL3 Y 317 - S6 L 87 N.S6.05
Van-der-waals ICL3 Y 317 - S6 L 87 N.S6.05
Hydrophobic TM5 R 305 5x66 s5s6 G 80 N.s5s6.09