Beta-arrestin-2 - GPR139 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR139 73.5
Beta-arrestin-2 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 229 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 229 6x36 s5s6 L 72 N.s5s6.08
Polar ICL3 R 217 - S6 R 77 N.S6.02
Hydrophobic ICL3 R 217 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 217 - S6 R 77 N.S6.02
Aromatic ICL3 F 216 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 F 216 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 F 216 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 P 133 34x50 S6 F 76 N.S6.01
Hydrophobic ICL2 L 134 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 134 34x51 S15 I 242 C.S15.14
Polar ICL3 L 218 - S6 R 77 N.S6.02
Polar ICL2 L 134 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 134 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 134 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL3 F 216 - S6 R 77 N.S6.02
Van-der-waals ICL3 F 216 - S6 R 77 N.S6.02
Polar TM5 K 213 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 213 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 213 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 F 216 - S5 F 62 N.S5.10
Hydrophobic TM3 A 129 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 129 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 H 137 34x54 s5s6 R 66 N.s5s6.02
Aromatic ICL2 H 137 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 H 137 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 H 137 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 V 130 3x54 s5s6 L 74 N.s5s6.10
Polar TM2 K 60 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 K 60 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 V 130 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 130 3x54 S6 F 76 N.S6.01
Hydrophobic ICL3 F 216 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 216 - S6 K 78 N.S6.03
Hydrophobic TM2 L 66 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 66 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 S 62 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 Y 136 34x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 Y 136 34x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 F 216 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 F 216 - s15s16 L 244 C.s15s16.02
Polar ICL1 R 58 12x52 s20c Q 407 C.s20c.17
Van-der-waals ICL1 R 58 12x52 s20c Q 407 C.s20c.17
Ionic H8 R 291 8x49 s5s6 D 68 N.s5s6.04
Polar H8 R 291 8x49 s5s6 D 68 N.s5s6.04
Polar ICL2 P 133 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 133 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 133 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 133 34x50 s5s6 L 69 N.s5s6.05
Polar ICL3 R 219 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL3 R 219 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL1 Q 59 12x53 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 Q 59 12x53 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 T 226 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 226 6x33 s5s6 L 74 N.s5s6.10
Ionic C-term K 350 - ns1 E 3 N.ns1.10
Polar C-term K 350 - ns1 E 3 N.ns1.10
Hydrophobic C-term M 337 - S20 V 387 C.S20.02
Van-der-waals ICL3 R 219 - S10 R 166 N.S10.03
Hydrophobic ICL2 L 134 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 134 34x51 S16 A 248 C.S16.01
Ionic C-term H 333 - s19s20 D 384 C.s19s20.50
Polar C-term H 333 - s19s20 D 384 C.s19s20.50
Hydrophobic C-term H 333 - s19s20 D 384 C.s19s20.50
Hydrophobic TM6 T 226 6x33 s5s6 L 72 N.s5s6.08
Ionic ICL3 R 217 - S6 D 79 N.S6.04
Polar ICL3 R 217 - S6 D 79 N.S6.04
Hydrophobic ICL3 R 217 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 217 - S6 D 79 N.S6.04
Hydrophobic TM7 I 288 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 126 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 K 213 5x68 S6 F 76 N.S6.01
Hydrophobic TM6 Y 221 6x28 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 Y 221 6x28 s5s6 L 72 N.s5s6.08
Ionic TM3 R 126 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 R 126 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 126 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 126 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 R 219 - S6 R 77 N.S6.02
Hydrophobic ICL3 L 218 - S6 F 76 N.S6.01
Van-der-waals ICL3 L 218 - S6 F 76 N.S6.01
Hydrophobic TM6 G 220 6x27 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 G 220 6x27 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 L 134 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 134 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 210 5x65 s5s6 L 74 N.s5s6.10
Polar ICL3 R 219 - s20c L 408 C.s20c.18
Hydrophobic ICL3 R 219 - s20c L 408 C.s20c.18
Van-der-waals ICL3 R 219 - s20c L 408 C.s20c.18
Ionic TM2 K 60 2x37 s5s6 D 68 N.s5s6.04
Polar TM2 K 60 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 K 60 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 L 210 5x65 S6 F 76 N.S6.01
Hydrophobic TM7 Y 285 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 285 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic C-term I 335 - H1 K 108 N.H1.09
Van-der-waals C-term I 335 - H1 K 108 N.H1.09
Polar ICL2 L 134 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 134 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 134 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 230 6x37 s5s6 L 72 N.s5s6.08
Polar H8 S 289 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 289 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 289 8x47 s5s6 V 71 N.s5s6.07
Polar ICL1 R 58 12x52 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 58 12x52 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 58 12x52 s20c Y 404 C.s20c.14
Hydrophobic ICL3 L 218 - s5s6 S 75 N.s5s6.11