Beta-arrestin-2 - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR141 77.6
Beta-arrestin-2 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 52 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 W 222 6x32 s5s6 L 74 N.s5s6.10
Polar TM4 K 129 4x39 s20c Y 404 C.s20c.14
Van-der-waals TM4 K 129 4x39 s20c Y 404 C.s20c.14
Polar ICL1 N 46 12x49 s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 N 46 12x49 s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 N 46 12x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM7 F 283 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 F 283 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 M 45 12x48 s5s6 D 68 N.s5s6.04
Polar ICL2 D 122 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 D 122 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 D 122 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 A 223 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 223 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 D 122 34x52 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 D 122 34x52 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 D 122 34x52 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 I 109 3x46 s5s6 L 72 N.s5s6.08
Polar TM6 Q 219 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 Q 219 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 219 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic ICL4 G 287 - s5s6 G 73 N.s5s6.09
Van-der-waals ICL4 G 287 - s5s6 G 73 N.s5s6.09
Polar H8 H 289 8x48 S6 R 77 N.S6.02
Van-der-waals H8 H 289 8x48 S6 R 77 N.S6.02
Polar ICL2 C 120 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 C 120 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 C 120 34x50 s8s9 T 137 N.s8s9.07
Ionic ICL2 K 123 34x53 s5s6 D 68 N.s5s6.04
Polar ICL2 K 123 34x53 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 K 123 34x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 V 55 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 55 2x43 s5s6 V 71 N.s5s6.07
Polar TM6 K 226 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 K 226 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 226 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 T 51 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 F 283 7x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 F 283 7x53 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 M 45 12x48 s5s6 L 69 N.s5s6.05
Van-der-waals ICL1 M 45 12x48 s5s6 L 69 N.s5s6.05
Ionic TM3 R 113 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 R 113 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 113 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 113 3x50 s5s6 D 70 N.s5s6.06
Polar TM6 E 220 6x30 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 E 220 6x30 s15s16 S 246 C.s15s16.04
Van-der-waals TM6 E 220 6x30 s15s16 S 246 C.s15s16.04
Hydrophobic ICL1 M 45 12x48 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 M 45 12x48 s5s6 V 71 N.s5s6.07
Polar ICL2 D 122 34x52 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 D 122 34x52 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 D 122 34x52 s8s9 D 136 N.s8s9.06
Polar ICL3 H 218 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 H 218 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 H 218 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 M 45 12x48 s5s6 D 70 N.s5s6.06
Van-der-waals ICL1 M 45 12x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 51 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 113 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 113 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 Q 219 6x29 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 Q 219 6x29 s15s16 F 245 C.s15s16.03
Polar TM2 T 51 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 51 2x39 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 T 51 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM1 I 38 1x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM1 I 38 1x54 s5s6 V 71 N.s5s6.07
Polar TM6 Q 219 6x29 S6 F 76 N.S6.01
Hydrophobic TM6 Q 219 6x29 S6 F 76 N.S6.01
Van-der-waals TM6 Q 219 6x29 S6 F 76 N.S6.01
Polar TM6 Q 219 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 Q 219 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 Q 219 6x29 s5s6 L 74 N.s5s6.10
Polar TM6 K 226 6x36 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 226 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 F 230 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 230 6x40 s5s6 L 72 N.s5s6.08
Polar TM3 R 113 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 113 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 113 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 K 121 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 K 121 34x51 s8s9 T 137 N.s8s9.07
Polar H8 K 292 8x51 s5s6 S 75 N.s5s6.11
Van-der-waals H8 K 292 8x51 s5s6 S 75 N.s5s6.11
Polar H8 K 292 8x51 s5s6 G 73 N.s5s6.09
Van-der-waals H8 K 292 8x51 s5s6 G 73 N.s5s6.09
Polar ICL2 D 122 34x52 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 D 122 34x52 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 D 122 34x52 s8s9 G 138 N.s8s9.08
Hydrophobic TM6 E 220 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 E 220 6x30 s15s16 F 245 C.s15s16.03