S-arrestin - GPR142 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR142 58.2
S-arrestin 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM7 V 417 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 V 417 7x56 s5s6 I 79 N.s5s6.08
Polar N-term Q 13 - s10s11 R 193 C.s10s11.10
Hydrophobic N-term Q 13 - s10s11 R 193 C.s10s11.10
Van-der-waals N-term Q 13 - s10s11 R 193 C.s10s11.10
Hydrophobic N-term I 12 - S11 A 194 C.S11.01
Hydrophobic N-term M 5 - S11 W 198 C.S11.05
Van-der-waals N-term M 5 - S11 W 198 C.S11.05
Polar ICL2 H 265 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 H 265 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 H 265 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 P 263 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 263 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic N-term M 5 - S19 S 349 C.S19.01
Van-der-waals N-term M 5 - S19 S 349 C.S19.01
Polar H8 K 419 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 R 267 34x54 S5 Y 71 N.S5.12
Aromatic ICL2 R 267 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 267 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 267 34x54 S5 Y 71 N.S5.12
Polar N-term T 17 - s12s13 E 216 C.s12s13.03
Polar ICL2 H 265 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic N-term L 26 - S15 N 250 C.S15.13
Hydrophobic N-term M 8 - s11s12 P 206 C.s11s12.07
Ionic TM2 R 190 2x37 s5s6 D 75 N.s5s6.04
Polar TM2 R 190 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 R 190 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 190 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic N-term I 3 - s18s19 G 341 C.s18s19.04
Hydrophobic TM6 L 348 6x26 S6 D 86 N.S6.04
Hydrophobic TM3 R 256 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 256 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 S 192 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 192 2x39 s5s6 V 78 N.s5s6.07
Polar N-term Q 20 - s17s18 I 316 C.s17s18.32
Hydrophobic N-term Q 20 - s17s18 I 316 C.s17s18.32
Van-der-waals N-term Q 20 - s17s18 I 316 C.s17s18.32
Polar TM2 Y 193 2x40 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 Y 193 2x40 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 Y 193 2x40 s5s6 D 77 N.s5s6.06
Polar ICL3 R 343 - s15s16 Y 254 C.s15s16.03
Aromatic ICL3 R 343 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 R 343 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 R 343 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 R 267 34x54 S9 C 147 N.S9.01
Van-der-waals ICL2 R 267 34x54 S9 C 147 N.S9.01
Hydrophobic N-term I 3 - s11s12 F 200 C.s11s12.01
Polar N-term Q 10 - S19 A 352 C.S19.04
Van-der-waals N-term Q 10 - S19 A 352 C.S19.04
Ionic N-term D 21 - S19 R 358 C.S19.10
Polar N-term D 21 - S19 R 358 C.S19.10
Hydrophobic N-term D 21 - S19 R 358 C.S19.10
Van-der-waals N-term D 21 - S19 R 358 C.S19.10
Hydrophobic N-term W 14 - s10s11 P 192 C.s10s11.09
Van-der-waals N-term W 14 - s10s11 P 192 C.s10s11.09
Polar N-term L 6 - S11 Q 199 C.S11.06
Polar H8 T 420 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 T 420 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 420 8x49 s5s6 D 77 N.s5s6.06
Polar TM4 S 270 4x38 s8s9 K 145 N.s8s9.09
Van-der-waals TM4 S 270 4x38 s8s9 K 145 N.s8s9.09
Hydrophobic N-term M 5 - S19 V 351 C.S19.03
Van-der-waals N-term M 5 - S19 V 351 C.S19.03
Hydrophobic N-term L 26 - S18 S 330 C.S18.04
Van-der-waals N-term L 26 - S18 S 330 C.S18.04
Polar ICL2 L 264 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 264 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 264 34x51 S5 Y 71 N.S5.12
Polar N-term M 8 - S11 A 197 C.S11.04
Hydrophobic N-term M 8 - S11 A 197 C.S11.04
Van-der-waals N-term M 8 - S11 A 197 C.S11.04
Hydrophobic N-term V 25 - s17s18 R 322 C.s17s18.38
Van-der-waals N-term V 25 - s17s18 R 322 C.s17s18.38
Hydrophobic TM6 I 358 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 358 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic N-term L 26 - S16 Y 258 C.S16.02
Van-der-waals N-term L 26 - S16 Y 258 C.S16.02
Polar N-term Q 10 - S19 T 353 C.S19.05
Hydrophobic N-term I 22 - s17s18 I 316 C.s17s18.32
Van-der-waals N-term I 22 - s17s18 I 316 C.s17s18.32
Hydrophobic N-term I 22 - S18 S 330 C.S18.04
Hydrophobic N-term I 22 - S18 V 329 C.S18.03
Van-der-waals N-term I 22 - S18 V 329 C.S18.03
Hydrophobic TM6 L 348 6x26 S6 F 89 N.S6.07
Hydrophobic N-term I 12 - S19 P 356 C.S19.08
Polar N-term E 9 - S11 A 197 C.S11.04
Van-der-waals N-term E 9 - S11 A 197 C.S11.04
Hydrophobic TM3 A 259 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 259 3x53 S6 F 83 N.S6.01
Hydrophobic N-term L 19 - s17s18 I 315 C.s17s18.31
Polar N-term L 19 - S19 R 358 C.S19.10
Polar ICL2 P 263 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 P 263 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 263 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 C 261 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 359 6x37 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 359 6x37 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 264 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 264 34x51 S15 V 251 C.S15.14
Hydrophobic N-term T 17 - s10s11 G 189 C.s10s11.06
Hydrophobic N-term P 7 - S11 W 198 C.S11.05
Van-der-waals N-term P 7 - S11 W 198 C.S11.05
Hydrophobic TM6 I 362 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic N-term T 23 - S18 S 330 C.S18.04
Hydrophobic H8 S 418 8x47 s5s6 I 79 N.s5s6.08
Polar N-term K 11 - S11 E 195 C.S11.02
Van-der-waals N-term K 11 - S11 E 195 C.S11.02
Polar N-term T 17 - S19 R 358 C.S19.10
Van-der-waals N-term T 17 - S19 R 358 C.S19.10
Hydrophobic N-term M 4 - s11s12 F 201 C.s11s12.02
Van-der-waals N-term M 4 - s11s12 F 201 C.s11s12.02
Hydrophobic N-term M 8 - S11 Q 199 C.S11.06
Hydrophobic N-term I 22 - s17s18 T 314 C.s17s18.30
Van-der-waals N-term I 22 - s17s18 T 314 C.s17s18.30
Polar ICL2 L 264 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 264 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 264 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 R 267 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 267 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 267 34x54 s8s9 K 145 N.s8s9.09
Polar TM2 Y 193 2x40 s5s6 V 78 N.s5s6.07
Polar TM5 R 339 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 339 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic N-term Q 10 - S11 E 195 C.S11.02
Van-der-waals N-term Q 10 - S11 E 195 C.S11.02
Hydrophobic N-term K 11 - S11 A 194 C.S11.01
Van-der-waals N-term K 11 - S11 A 194 C.S11.01
Van-der-waals ICL2 R 267 34x54 s5s6 G 72 N.s5s6.01
Polar H8 S 418 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 418 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 418 8x47 s5s6 D 77 N.s5s6.06
Ionic TM6 R 351 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 351 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 351 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 351 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic N-term L 26 - S15 V 248 C.S15.11
Van-der-waals N-term L 26 - S15 V 248 C.S15.11
Van-der-waals ICL2 R 267 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 264 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 264 34x51 S16 D 257 C.S16.01
Hydrophobic N-term W 14 - s12s13 E 216 C.s12s13.03
Van-der-waals N-term W 14 - s12s13 E 216 C.s12s13.03
Hydrophobic N-term T 23 - S19 P 356 C.S19.08
Van-der-waals N-term T 23 - S19 P 356 C.S19.08
Polar ICL2 P 263 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 263 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 263 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 S 355 6x33 s5s6 L 81 N.s5s6.10
Polar ICL2 R 267 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic ICL2 R 267 34x54 s8s9 S 146 N.s8s9.10
Van-der-waals ICL2 R 267 34x54 s8s9 S 146 N.s8s9.10
Hydrophobic TM3 R 256 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic N-term L 19 - s3s4 V 39 N.s3s4.02
Hydrophobic ICL2 A 268 34x55 S16 D 257 C.S16.01
Hydrophobic ICL2 L 264 34x51 s15s16 S 256 C.s15s16.05
Hydrophobic N-term Q 10 - S11 A 196 C.S11.03
Hydrophobic N-term I 3 - s14s15 K 236 C.s14s15.04
Polar TM2 R 190 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 R 190 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 R 190 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic N-term L 6 - S11 W 198 C.S11.05
Polar ICL3 S 346 - S6 R 85 N.S6.03
Van-der-waals ICL3 S 346 - S6 R 85 N.S6.03
Polar TM3 H 262 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 H 262 3x56 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 H 262 3x56 s15s16 S 255 C.s15s16.04
Polar N-term W 14 - S19 P 356 C.S19.08
Hydrophobic N-term W 14 - S19 P 356 C.S19.08
Van-der-waals N-term W 14 - S19 P 356 C.S19.08
Hydrophobic ICL2 L 264 34x51 S16 Y 259 C.S16.03
Polar TM2 R 190 2x37 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 R 190 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic N-term L 19 - s17s18 K 317 C.s17s18.33
Hydrophobic N-term M 5 - s11s12 F 200 C.s11s12.01
Van-der-waals N-term M 5 - s11s12 F 200 C.s11s12.01
Van-der-waals N-term E 9 - S11 A 196 C.S11.03
Hydrophobic N-term I 22 - S18 L 328 C.S18.02
Van-der-waals N-term I 22 - S18 L 328 C.S18.02
Polar TM6 Q 349 6x27 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 Q 349 6x27 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 Q 349 6x27 s9s10 E 164 N.s9s10.06
Hydrophobic TM3 L 260 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 L 260 3x54 S6 F 83 N.S6.01
Polar N-term Q 20 - s17s18 R 322 C.s17s18.38
Van-der-waals N-term Q 20 - s17s18 R 322 C.s17s18.38
Van-der-waals N-term Y 31 - S16 V 260 C.S16.04
Hydrophobic N-term V 15 - s10s11 P 190 C.s10s11.07
Hydrophobic N-term L 19 - s17s18 I 316 C.s17s18.32
Van-der-waals N-term L 19 - s17s18 I 316 C.s17s18.32