Beta-arrestin-1 - GPR143 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR143 67.6
Beta-arrestin-1 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 141 3x50 s5s6 V 70 N.s5s6.07
Polar TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic ICL1 G 58 - s20c E 404 C.s20c.14
Van-der-waals ICL1 G 58 - s20c E 404 C.s20c.14
Hydrophobic ICL1 P 65 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 P 65 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 Y 231 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 R 245 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic C-term W 329 - S6 K 77 N.S6.03
Polar ICL1 P 60 - s20c E 404 C.s20c.14
Hydrophobic ICL1 P 60 - s20c E 404 C.s20c.14
Hydrophobic TM3 V 144 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 V 144 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 F 246 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 246 6x33 s5s6 L 71 N.s5s6.08
Polar TM3 Y 137 3x46 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 137 3x46 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 137 3x46 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 E 235 6x22 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 E 235 6x22 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 G 150 - s8s9 T 136 N.s8s9.07
Polar ICL3 Y 231 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL3 Y 231 - s5s6 D 67 N.s5s6.04
Polar C-term R 324 - s5s6 G 72 N.s5s6.09
Hydrophobic C-term R 324 - s5s6 G 72 N.s5s6.09
Van-der-waals C-term R 324 - s5s6 G 72 N.s5s6.09
Hydrophobic ICL3 Y 231 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL3 Y 231 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term P 323 - s9s10 K 157 N.s9s10.09
Hydrophobic ICL2 L 151 - s8s9 P 133 N.s8s9.04
Aromatic C-term W 329 - S6 F 75 N.S6.01
Hydrophobic C-term W 329 - S6 F 75 N.S6.01
Van-der-waals C-term W 329 - S6 F 75 N.S6.01
Polar ICL1 A 61 - s20c D 402 C.s20c.12
Hydrophobic ICL1 A 61 - s20c D 402 C.s20c.12
Van-der-waals ICL1 A 61 - s20c D 402 C.s20c.12
Hydrophobic ICL2 A 149 - s8s9 T 136 N.s8s9.07
Polar C-term I 327 - s5s6 T 74 N.s5s6.11
Hydrophobic ICL1 R 52 - s9s10 R 161 N.s9s10.13
Van-der-waals ICL1 R 52 - s9s10 R 161 N.s9s10.13
Hydrophobic ICL1 P 65 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL1 P 65 - s8s9 K 138 N.s8s9.09
Hydrophobic TM3 S 148 3x57 s8s9 T 136 N.s8s9.07
Van-der-waals TM3 S 148 3x57 s8s9 T 136 N.s8s9.07
Polar C-term R 324 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term R 324 - s5s6 T 74 N.s5s6.11
Polar TM2 S 67 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 S 67 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 S 67 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL1 P 57 - s20c E 405 C.s20c.15
Van-der-waals ICL1 P 57 - s20c E 405 C.s20c.15
Polar TM6 R 245 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 R 245 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 R 245 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 145 3x54 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 I 145 3x54 s5s6 D 67 N.s5s6.04
Ionic TM6 E 235 6x22 s5s6 R 65 N.s5s6.02
Polar TM6 E 235 6x22 s5s6 R 65 N.s5s6.02
Van-der-waals TM6 E 235 6x22 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 V 241 6x28 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 241 6x28 s5s6 L 73 N.s5s6.10
Ionic C-term R 324 - s5s6 D 69 N.s5s6.06
Polar C-term R 324 - s5s6 D 69 N.s5s6.06
Van-der-waals C-term R 324 - s5s6 D 69 N.s5s6.06
Polar C-term I 327 - S6 R 76 N.S6.02
Van-der-waals C-term I 327 - S6 R 76 N.S6.02
Polar C-term Q 321 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term Q 321 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term Q 321 - s9s10 K 157 N.s9s10.09
Ionic C-term E 326 - S5 R 62 N.S5.11
Hydrophobic TM6 M 238 6x25 s5s6 L 68 N.s5s6.05
Van-der-waals TM6 M 238 6x25 s5s6 L 68 N.s5s6.05
Polar C-term Q 321 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term Q 321 - s9s10 H 159 N.s9s10.11
Hydrophobic ICL1 P 65 - s5s6 D 69 N.s5s6.06
Van-der-waals ICL1 P 65 - s5s6 D 69 N.s5s6.06
Polar C-term W 329 - S6 R 76 N.S6.02
Polar C-term R 324 - s5s6 L 73 N.s5s6.10
Polar C-term Q 328 - S6 R 76 N.S6.02
Van-der-waals C-term Q 328 - S6 R 76 N.S6.02
Hydrophobic TM6 I 242 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 I 242 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic C-term I 327 - s5s6 L 73 N.s5s6.10
Polar ICL1 G 58 - s17s18 K 292 C.s17s18.18
Van-der-waals ICL1 G 58 - s17s18 K 292 C.s17s18.18
Polar TM2 A 66 2x38 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 A 66 2x38 s5s6 E 66 N.s5s6.03
Ionic C-term E 326 - S6 R 76 N.S6.02
Polar C-term E 326 - S6 R 76 N.S6.02
Hydrophobic C-term E 326 - S6 R 76 N.S6.02
Van-der-waals C-term E 326 - S6 R 76 N.S6.02
Hydrophobic TM6 I 242 6x29 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 242 6x29 s5s6 L 71 N.s5s6.08
Polar C-term Q 328 - S6 D 78 N.S6.04
Van-der-waals C-term Q 328 - S6 D 78 N.S6.04
Hydrophobic C-term W 329 - s15s16 F 244 C.s15s16.03
Hydrophobic TM3 V 144 3x53 s5s6 E 66 N.s5s6.03
Van-der-waals TM3 V 144 3x53 s5s6 E 66 N.s5s6.03
Polar ICL1 A 55 - s9s10 K 160 N.s9s10.12
Van-der-waals ICL1 A 55 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL1 P 54 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL1 A 55 - s20c E 405 C.s20c.15
Van-der-waals ICL1 A 55 - s20c E 405 C.s20c.15
Hydrophobic TM6 M 238 6x25 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 M 238 6x25 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 M 238 6x25 S6 F 75 N.S6.01
Van-der-waals TM6 M 238 6x25 S6 F 75 N.S6.01