Beta-arrestin-2 - GPR143 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR143 66.5
Beta-arrestin-2 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 R 245 6x32 s5s6 V 71 N.s5s6.07
Van-der-waals C-term I 327 - S6 R 77 N.S6.02
Hydrophobic ICL1 G 58 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 G 58 - s20c Y 404 C.s20c.14
Hydrophobic ICL3 Y 231 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 Y 231 - s15s16 F 245 C.s15s16.03
Hydrophobic TM3 Y 137 3x46 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 Y 137 3x46 s5s6 L 72 N.s5s6.08
Polar C-term S 322 - s5s6 G 73 N.s5s6.09
Polar ICL2 G 150 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 G 150 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 G 150 - s8s9 T 137 N.s8s9.07
Polar TM6 R 245 6x32 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 R 245 6x32 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 R 245 6x32 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 G 58 - s20c D 402 C.s20c.12
Van-der-waals ICL1 G 58 - s20c D 402 C.s20c.12
Polar ICL1 T 62 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 T 62 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 T 62 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 P 60 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 P 65 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 P 65 - s5s6 D 68 N.s5s6.04
Polar C-term K 325 - s5s6 S 75 N.s5s6.11
Polar ICL2 L 151 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 151 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 151 - s8s9 T 137 N.s8s9.07
Polar ICL1 P 60 - s20c D 402 C.s20c.12
Hydrophobic ICL1 P 60 - s20c D 402 C.s20c.12
Van-der-waals ICL1 P 60 - s20c D 402 C.s20c.12
Hydrophobic ICL2 L 151 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 L 151 - s8s9 E 135 N.s8s9.05
Polar ICL1 S 59 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 S 59 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 S 59 - s20c Y 404 C.s20c.14
Hydrophobic TM6 R 245 6x32 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 V 68 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 68 2x40 s5s6 V 71 N.s5s6.07
Polar ICL1 G 58 - s20c D 403 C.s20c.13
Hydrophobic C-term I 327 - s5s6 L 74 N.s5s6.10
Van-der-waals C-term I 327 - s5s6 L 74 N.s5s6.10
Hydrophobic TM2 L 71 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 71 2x43 s5s6 V 71 N.s5s6.07
Polar TM6 E 235 6x22 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 E 235 6x22 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 E 235 6x22 s15s16 F 245 C.s15s16.03
Polar TM3 V 144 3x53 s15s16 S 246 C.s15s16.04
Polar ICL2 A 149 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 A 149 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 A 149 - s8s9 T 137 N.s8s9.07
Ionic C-term R 324 - s5s6 D 70 N.s5s6.06
Polar C-term R 324 - s5s6 D 70 N.s5s6.06
Hydrophobic C-term R 324 - s5s6 D 70 N.s5s6.06
Van-der-waals C-term R 324 - s5s6 D 70 N.s5s6.06
Hydrophobic TM6 I 242 6x29 s5s6 L 74 N.s5s6.10
Ionic C-term E 326 - S5 R 63 N.S5.11
Polar C-term E 326 - S5 R 63 N.S5.11
Van-der-waals C-term E 326 - S5 R 63 N.S5.11
Hydrophobic TM6 M 238 6x25 S6 F 76 N.S6.01
Van-der-waals TM6 M 238 6x25 S6 F 76 N.S6.01
Polar TM2 S 67 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 67 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 67 2x39 s5s6 D 68 N.s5s6.04
Polar ICL1 P 65 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 P 65 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 P 65 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 L 151 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 L 151 - s8s9 P 134 N.s8s9.04
Ionic C-term E 326 - S6 R 77 N.S6.02
Polar C-term E 326 - S6 R 77 N.S6.02
Hydrophobic C-term E 326 - S6 R 77 N.S6.02
Van-der-waals C-term E 326 - S6 R 77 N.S6.02
Polar TM3 S 148 3x57 s15s16 T 247 C.s15s16.05
Polar TM2 A 66 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 A 66 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 66 2x38 s5s6 D 68 N.s5s6.04
Ionic C-term E 326 - S10 R 166 N.S10.03
Hydrophobic C-term R 324 - s5s6 S 75 N.s5s6.11
Van-der-waals C-term R 324 - s5s6 S 75 N.s5s6.11
Hydrophobic TM6 I 242 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 P 65 - s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 P 65 - s5s6 V 71 N.s5s6.07
Hydrophobic TM6 M 238 6x25 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 238 6x25 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 M 238 6x25 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 Y 137 3x46 s5s6 V 71 N.s5s6.07
Hydrophobic C-term W 329 - S6 F 76 N.S6.01
Hydrophobic TM6 V 241 6x28 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 241 6x28 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 S 148 3x57 S16 A 248 C.S16.01
Van-der-waals TM3 S 148 3x57 S16 A 248 C.S16.01
Hydrophobic TM6 I 242 6x29 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 M 238 6x25 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 M 238 6x25 s5s6 L 69 N.s5s6.05
Polar TM3 V 144 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 V 144 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 V 144 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic C-term W 329 - S6 K 78 N.S6.03
Van-der-waals C-term W 329 - S6 K 78 N.S6.03
Hydrophobic TM2 S 67 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 S 67 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 S 63 - s5s6 E 67 N.s5s6.03