S-arrestin - GPR146 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR146 67.9
S-arrestin 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL3 D 221 - s8s9 K 145 N.s8s9.09
Polar ICL3 D 221 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 D 221 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL3 D 221 - s8s9 K 145 N.s8s9.09
Hydrophobic TM6 T 224 6x26 s17s18 G 296 C.s17s18.12
Hydrophobic TM6 D 223 6x25 s8s9 A 139 N.s8s9.03
Van-der-waals TM6 D 223 6x25 s8s9 A 139 N.s8s9.03
Hydrophobic TM3 L 133 3x56 S5 Y 71 N.S5.12
Hydrophobic C-term M 326 - S11 E 195 C.S11.02
Polar ICL3 T 218 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 T 218 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL3 T 218 - s8s9 D 142 N.s8s9.06
Hydrophobic C-term A 333 - s18s19 G 341 C.s18s19.04
Van-der-waals C-term A 333 - s18s19 G 341 C.s18s19.04
Polar ICL2 R 135 - s8s9 S 146 N.s8s9.10
Hydrophobic ICL2 R 135 - s8s9 S 146 N.s8s9.10
Van-der-waals ICL2 R 135 - s8s9 S 146 N.s8s9.10
Hydrophobic C-term V 328 - S11 Q 199 C.S11.06
Van-der-waals C-term V 328 - S11 Q 199 C.S11.06
Polar TM3 A 132 3x55 S5 Y 71 N.S5.12
Hydrophobic TM3 A 132 3x55 S5 Y 71 N.S5.12
Van-der-waals TM3 A 132 3x55 S5 Y 71 N.S5.12
Hydrophobic C-term L 332 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term L 332 - s11s12 F 201 C.s11s12.02
Hydrophobic ICL3 D 221 - s8s9 S 143 N.s8s9.07
Hydrophobic C-term V 331 - S19 V 351 C.S19.03
Hydrophobic ICL3 L 220 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL3 L 220 - s8s9 P 138 N.s8s9.02
Polar ICL2 Y 137 - s15s16 Y 254 C.s15s16.03
Aromatic ICL2 Y 137 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 Y 137 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 Y 137 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 D 221 - s8s9 P 138 N.s8s9.02
Van-der-waals ICL3 D 221 - s8s9 P 138 N.s8s9.02
Hydrophobic ICL2 P 134 - S5 Y 71 N.S5.12
Van-der-waals ICL2 P 134 - S5 Y 71 N.S5.12
Polar TM6 D 223 6x25 s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 D 223 6x25 s8s9 Q 141 N.s8s9.05
Van-der-waals TM6 D 223 6x25 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL2 R 135 - s5s6 G 72 N.s5s6.01
Hydrophobic ICL2 R 135 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 135 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 A 132 3x55 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 A 132 3x55 s5s6 V 78 N.s5s6.07
Polar C-term Q 329 - S11 A 197 C.S11.04
Van-der-waals C-term Q 329 - S11 A 197 C.S11.04
Polar ICL3 L 220 - s8s9 A 139 N.s8s9.03
Hydrophobic ICL3 L 220 - s8s9 A 139 N.s8s9.03
Van-der-waals ICL3 L 220 - s8s9 A 139 N.s8s9.03
Hydrophobic C-term A 333 - s14s15 K 236 C.s14s15.04
Van-der-waals C-term A 333 - s14s15 K 236 C.s14s15.04
Polar ICL2 Y 137 - s15s16 V 252 C.s15s16.01
Hydrophobic TM3 L 133 3x56 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 D 221 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 D 221 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL3 L 220 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 L 220 - s8s9 Q 141 N.s8s9.05
Polar TM3 R 131 3x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 T 136 - S6 F 83 N.S6.01
Hydrophobic C-term V 331 - S11 W 198 C.S11.05
Van-der-waals C-term V 331 - S11 W 198 C.S11.05
Polar C-term V 331 - S11 Q 199 C.S11.06
Van-der-waals C-term V 331 - S11 Q 199 C.S11.06
Hydrophobic TM5 D 217 5x68 s8s9 D 142 N.s8s9.06
Ionic TM6 R 226 6x28 s8s9 D 142 N.s8s9.06
Polar TM6 R 226 6x28 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 R 226 6x28 s8s9 D 142 N.s8s9.06
Van-der-waals TM6 R 226 6x28 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 D 223 6x25 s8s9 P 140 N.s8s9.04
Van-der-waals TM6 D 223 6x25 s8s9 P 140 N.s8s9.04
Polar ICL3 L 220 - s8s9 S 143 N.s8s9.07
Hydrophobic ICL3 L 220 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL3 L 220 - s8s9 S 143 N.s8s9.07
Hydrophobic ICL2 R 135 - S5 Y 71 N.S5.12
Van-der-waals ICL2 R 135 - S5 Y 71 N.S5.12
Hydrophobic ICL2 R 135 - S5 F 69 N.S5.10
Van-der-waals ICL2 R 135 - S5 F 69 N.S5.10
Polar ICL2 Y 137 - S6 R 85 N.S6.03
Van-der-waals ICL2 Y 137 - S6 R 85 N.S6.03
Van-der-waals ICL3 D 221 - s8s9 P 140 N.s8s9.04
Polar ICL3 L 220 - s8s9 P 140 N.s8s9.04
Hydrophobic ICL3 L 220 - s8s9 P 140 N.s8s9.04
Van-der-waals ICL3 L 220 - s8s9 P 140 N.s8s9.04
Hydrophobic ICL2 R 135 - S9 C 147 N.S9.01
Van-der-waals ICL2 R 135 - S9 C 147 N.S9.01
Polar ICL3 P 219 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL3 P 219 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 P 219 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 Y 137 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 Y 137 - s15s16 L 253 C.s15s16.02
Hydrophobic TM3 L 133 3x56 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 P 219 - s8s9 P 140 N.s8s9.04
Van-der-waals ICL3 P 219 - s8s9 P 140 N.s8s9.04
Polar TM6 T 224 6x26 s8s9 A 139 N.s8s9.03
Hydrophobic TM6 T 224 6x26 s8s9 A 139 N.s8s9.03
Van-der-waals TM6 T 224 6x26 s8s9 A 139 N.s8s9.03
Polar TM6 R 222 6x24 s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 R 222 6x24 s8s9 Q 141 N.s8s9.05
Van-der-waals TM6 R 222 6x24 s8s9 Q 141 N.s8s9.05
Polar C-term V 331 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term V 331 - s11s12 F 201 C.s11s12.02
Hydrophobic ICL2 R 135 - S6 F 83 N.S6.01
Van-der-waals ICL2 R 135 - S6 F 83 N.S6.01
Hydrophobic ICL3 L 220 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL3 L 220 - s8s9 D 142 N.s8s9.06
Van-der-waals C-term A 333 - s18s19 F 342 C.s18s19.05
Hydrophobic C-term V 328 - S11 W 198 C.S11.05
Van-der-waals C-term V 328 - S11 W 198 C.S11.05
Hydrophobic ICL3 D 221 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL3 D 221 - s8s9 D 142 N.s8s9.06
Polar C-term Q 329 - S11 W 198 C.S11.05
Hydrophobic C-term Q 329 - S11 W 198 C.S11.05
Van-der-waals C-term Q 329 - S11 W 198 C.S11.05
Hydrophobic C-term V 328 - S11 A 197 C.S11.04
Van-der-waals C-term V 328 - S11 A 197 C.S11.04
Hydrophobic C-term V 328 - s11s12 P 206 C.s11s12.07
Hydrophobic TM3 L 133 3x56 S6 F 83 N.S6.01
Van-der-waals TM3 L 133 3x56 S6 F 83 N.S6.01
Polar ICL3 T 218 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL3 T 218 - s5s6 Q 73 N.s5s6.02
Hydrophobic C-term V 331 - s11s12 F 200 C.s11s12.01
Van-der-waals C-term V 331 - s11s12 F 200 C.s11s12.01
Hydrophobic ICL2 T 136 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 T 136 - s15s16 Y 254 C.s15s16.03
Hydrophobic C-term V 331 - S19 S 349 C.S19.01
Polar ICL3 T 218 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL3 T 218 - s8s9 S 143 N.s8s9.07
Polar C-term Q 329 - S11 Q 199 C.S11.06
Van-der-waals C-term Q 329 - S11 Q 199 C.S11.06
Hydrophobic C-term G 327 - S11 A 197 C.S11.04
Hydrophobic ICL3 T 218 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL3 T 218 - s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 T 224 6x26 S16 Y 259 C.S16.03
Hydrophobic C-term A 333 - s11s12 F 200 C.s11s12.01
Van-der-waals C-term A 333 - s11s12 F 200 C.s11s12.01
Hydrophobic C-term A 333 - S19 S 349 C.S19.01
Ionic TM3 R 131 3x54 s8s9 D 142 N.s8s9.06
Polar TM6 R 222 6x24 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 R 222 6x24 s8s9 D 142 N.s8s9.06
Van-der-waals TM6 R 222 6x24 s8s9 D 142 N.s8s9.06
Polar ICL2 R 135 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 R 135 - s8s9 G 144 N.s8s9.08
Polar ICL2 R 135 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 135 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 135 - s8s9 K 145 N.s8s9.09
Polar ICL3 D 221 - s8s9 A 139 N.s8s9.03
Hydrophobic ICL3 D 221 - s8s9 A 139 N.s8s9.03
Van-der-waals ICL3 D 221 - s8s9 A 139 N.s8s9.03
Polar C-term Q 330 - S11 Q 199 C.S11.06
Hydrophobic C-term Q 330 - S11 Q 199 C.S11.06
Van-der-waals C-term Q 330 - S11 Q 199 C.S11.06
Hydrophobic ICL3 P 219 - s8s9 D 142 N.s8s9.06
Polar ICL2 R 135 - S5 R 70 N.S5.11
Hydrophobic ICL2 R 135 - S5 R 70 N.S5.11
Van-der-waals ICL2 R 135 - S5 R 70 N.S5.11