Beta-arrestin-1 - GPR148 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR148 68.4
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 R 323 8x53 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 A 149 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 A 149 3x53 S6 F 75 N.S6.01
Hydrophobic TM6 T 262 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 262 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 I 251 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 I 251 - s5s6 L 73 N.s5s6.10
Polar H8 Q 326 8x56 s5s6 E 66 N.s5s6.03
Van-der-waals H8 Q 326 8x56 s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 L 157 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 L 157 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 P 153 34x50 S6 F 75 N.S6.01
Van-der-waals ICL2 P 153 34x50 S6 F 75 N.S6.01
Hydrophobic TM2 E 83 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 L 154 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 154 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 154 34x51 s15s16 N 245 C.s15s16.04
Ionic TM2 E 83 2x37 s5s6 R 65 N.s5s6.02
Polar TM2 E 83 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic TM2 E 83 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 E 83 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 R 258 6x29 s5s6 G 72 N.s5s6.09
Polar ICL2 R 155 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 155 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 155 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 154 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 154 34x51 S15 I 241 C.S15.14
Ionic TM2 H 85 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 H 85 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 H 85 2x39 s5s6 D 67 N.s5s6.04
Polar TM6 T 262 6x33 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 262 6x33 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 262 6x33 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 H 145 3x49 s5s6 V 70 N.s5s6.07
Polar ICL2 P 153 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 153 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 153 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 154 34x51 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 L 154 34x51 s15s16 F 244 C.s15s16.03
Polar TM6 A 259 6x30 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 259 6x30 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 259 6x30 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 Y 156 34x53 s8s9 K 138 N.s8s9.09
Hydrophobic H8 Y 324 8x54 s5s6 V 70 N.s5s6.07
Van-der-waals H8 Y 324 8x54 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 157 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 157 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 157 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 L 157 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic TM6 A 259 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 259 6x30 s5s6 L 73 N.s5s6.10
Polar ICL2 S 158 34x55 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 S 158 34x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 T 146 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 T 146 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 150 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 150 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 V 150 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 150 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 L 154 34x51 S5 F 61 N.S5.10
Van-der-waals ICL2 L 154 34x51 S5 F 61 N.S5.10
Polar ICL2 L 157 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 157 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 157 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 H 85 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 H 85 2x39 s5s6 V 70 N.s5s6.07
Ionic TM6 R 258 6x29 s5s6 D 69 N.s5s6.06
Polar TM6 R 258 6x29 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 R 258 6x29 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 R 258 6x29 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 A 149 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 149 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 154 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 154 34x51 S5 Y 63 N.S5.12
Hydrophobic TM6 R 258 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 153 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 153 34x50 s15s16 F 244 C.s15s16.03
Ionic H8 R 325 8x55 s20c E 407 C.s20c.17
Polar H8 R 325 8x55 s20c E 407 C.s20c.17
Van-der-waals H8 R 325 8x55 s20c E 407 C.s20c.17
Hydrophobic TM4 S 161 4x38 s8s9 T 136 N.s8s9.07
Polar ICL2 R 155 34x52 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 155 34x52 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 I 242 - s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 154 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 L 154 34x51 s15s16 L 243 C.s15s16.02
Polar TM6 A 259 6x30 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 A 259 6x30 s5s6 G 72 N.s5s6.09
Van-der-waals ICL2 L 157 34x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 L 263 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 263 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 150 3x54 s5s6 L 71 N.s5s6.08
Polar TM6 G 253 6x24 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 G 253 6x24 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 G 253 6x24 s9s10 K 157 N.s9s10.09