Arrestin-C - GPR148 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR148 67.8
Arrestin-C 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
01
iPTM Score: 0.3
01
PAE mean: 21.2
031


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
R02D03D04E06I08G09s5s6P04s8s9K12s9s10Y01S10Y03S04s15s16ArrestinQ6x25A6x30H2x39L34x51R34x52R12x49Y34x53Q8x56R6x29R8x53T6x33GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsArrestin segments:s5s6s8s9s9s10S10s15s16GPCR segments:ICL1TM2ICL2TM6H8

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null12x492x372x393x503x533x5434x5034x5134x5234x5334x546x246x256x296x306x338x538x548x558x56C.s20c.17C.S16.01C.s15s16.04C.s15s16.03C.s15s16.02N.S10.01N.s9s10.12N.s9s10.09N.s8s9.09N.s8s9.04N.S6.01N.s5s6.10N.s5s6.09N.s5s6.08N.s5s6.07N.s5s6.06N.s5s6.05N.s5s6.04N.s5s6.03N.s5s6.02N.S5.12Res. Pos.GPR148 (AFM_GP148_HUMAN_ARRC_HUMAN)- (AFM_GP148_HUMAN_ARRC_HUMAN)---------------------REHTAVPLRYLGQRATRYRQREHPLRYLTAVGQRATRYRQIPDKDVYFLSRDYILLTYKEGE

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.