Beta-arrestin-1 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR150 58.4
Beta-arrestin-1 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 P 158 4x39 s8s9 D 135 N.s8s9.06
Polar C-term S 429 - S16 K 250 C.S16.04
Van-der-waals C-term S 429 - S16 K 250 C.S16.04
Hydrophobic TM2 R 80 2x37 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 R 80 2x37 s5s6 L 68 N.s5s6.05
Hydrophobic C-term A 406 - s19s20 K 357 C.s19s20.04
Van-der-waals C-term A 406 - s19s20 K 357 C.s19s20.04
Polar C-term W 398 - s7s8 E 118 N.s7s8.01
Hydrophobic C-term W 398 - s7s8 E 118 N.s7s8.01
Van-der-waals C-term W 398 - s7s8 E 118 N.s7s8.01
Hydrophobic C-term H 402 - s19s20 P 361 C.s19s20.08
Aromatic C-term H 405 - ns1 R 7 N.ns1.15
Polar ICL2 H 155 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 H 155 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 155 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term Q 396 - s7s8 E 118 N.s7s8.01
Van-der-waals C-term Q 396 - s7s8 E 118 N.s7s8.01
Hydrophobic H8 D 359 8x50 s5s6 G 72 N.s5s6.09
Van-der-waals H8 D 359 8x50 s5s6 G 72 N.s5s6.09
Hydrophobic C-term P 401 - s3s4 H 30 N.s3s4.01
Van-der-waals C-term P 401 - s3s4 H 30 N.s3s4.01
Polar C-term H 402 - s19s20 E 359 C.s19s20.06
Van-der-waals C-term H 402 - s19s20 E 359 C.s19s20.06
Polar C-term R 407 - ns1 M 1 N.ns1.09
Van-der-waals C-term R 407 - ns1 M 1 N.ns1.09
Polar C-term H 405 - s19s20 K 357 C.s19s20.04
Hydrophobic C-term H 405 - s19s20 K 357 C.s19s20.04
Van-der-waals C-term H 405 - s19s20 K 357 C.s19s20.04
Polar TM6 Q 292 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 Q 292 6x32 s5s6 L 71 N.s5s6.08
Polar ICL2 H 155 - S16 A 247 C.S16.01
Hydrophobic ICL2 H 155 - S16 A 247 C.S16.01
Van-der-waals ICL2 H 155 - S16 A 247 C.S16.01
Hydrophobic C-term C 430 - S16 A 247 C.S16.01
Hydrophobic C-term Y 403 - s19s20 E 358 C.s19s20.05
Van-der-waals C-term Y 403 - s19s20 E 358 C.s19s20.05
Hydrophobic C-term P 425 - s17s18 K 284 C.s17s18.10
Van-der-waals C-term P 425 - s17s18 K 284 C.s17s18.10
Hydrophobic C-term C 430 - s8s9 D 135 N.s8s9.06
Polar ICL1 K 78 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 K 78 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 K 78 - s5s6 R 65 N.s5s6.02
Hydrophobic TM2 L 86 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic H8 Q 356 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals C-term F 434 - s15s16 T 246 C.s15s16.05
Polar H8 Q 356 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 Q 356 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 Q 356 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals C-term H 402 - s19s20 K 357 C.s19s20.04
Hydrophobic C-term L 426 - S16 M 255 C.S16.09
Van-der-waals C-term L 426 - S16 M 255 C.S16.09
Ionic C-term R 407 - ns1 D 3 N.ns1.11
Polar C-term R 407 - ns1 D 3 N.ns1.11
Hydrophobic C-term R 407 - ns1 D 3 N.ns1.11
Van-der-waals C-term R 407 - ns1 D 3 N.ns1.11
Hydrophobic C-term R 395 - s6h1 K 95 N.s6h1.09
Van-der-waals C-term R 395 - s6h1 K 95 N.s6h1.09
Hydrophobic C-term C 428 - S16 K 250 C.S16.04
Van-der-waals C-term C 428 - S16 K 250 C.S16.04
Ionic C-term R 408 - s17s18 E 296 C.s17s18.22
Polar C-term R 422 - s17s18 N 280 C.s17s18.06
Hydrophobic C-term R 422 - s17s18 N 280 C.s17s18.06
Van-der-waals C-term R 422 - s17s18 N 280 C.s17s18.06
Polar C-term Y 403 - s19s20 K 357 C.s19s20.04
Hydrophobic C-term Y 403 - s19s20 K 357 C.s19s20.04
Van-der-waals C-term Y 403 - s19s20 K 357 C.s19s20.04
Polar C-term C 428 - s17s18 G 286 C.s17s18.12
Hydrophobic C-term C 428 - s17s18 G 286 C.s17s18.12
Polar C-term H 390 - S6 Q 85 N.S6.11
Van-der-waals C-term H 390 - S6 Q 85 N.S6.11
Polar TM2 R 80 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 80 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 80 2x37 s5s6 D 67 N.s5s6.04
Ionic C-term E 431 - S16 K 250 C.S16.04
Polar C-term E 431 - S16 K 250 C.S16.04
Hydrophobic C-term E 431 - S16 K 250 C.S16.04
Van-der-waals C-term E 431 - S16 K 250 C.S16.04
Hydrophobic C-term W 398 - s3s4 L 33 N.s3s4.04
Van-der-waals C-term W 398 - s3s4 L 33 N.s3s4.04
Hydrophobic TM4 P 158 4x39 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 P 158 4x39 s8s9 T 136 N.s8s9.07
Polar C-term C 430 - S16 Q 248 C.S16.02
Hydrophobic C-term C 430 - S16 Q 248 C.S16.02
Van-der-waals C-term C 430 - S16 Q 248 C.S16.02
Hydrophobic TM2 M 82 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 M 82 2x39 s5s6 V 70 N.s5s6.07
Polar C-term C 428 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term C 428 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term C 428 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term L 426 - s17s18 K 284 C.s17s18.10
Van-der-waals C-term L 426 - s17s18 K 284 C.s17s18.10
Hydrophobic TM6 P 287 6x27 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 P 287 6x27 s15s16 F 244 C.s15s16.03
Polar ICL1 K 78 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 K 78 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 K 78 - s5s6 D 67 N.s5s6.04
Polar C-term R 395 - s6h1 K 94 N.s6h1.08
Hydrophobic C-term R 395 - s6h1 K 94 N.s6h1.08
Van-der-waals C-term R 395 - s6h1 K 94 N.s6h1.08
Hydrophobic C-term H 390 - s9s10 L 154 N.s9s10.03
Polar C-term C 430 - S16 Y 249 C.S16.03
Hydrophobic C-term C 430 - S16 Y 249 C.S16.03
Van-der-waals C-term C 430 - S16 Y 249 C.S16.03
Hydrophobic TM6 P 287 6x27 S6 F 75 N.S6.01
Van-der-waals TM6 P 287 6x27 S6 F 75 N.S6.01
Hydrophobic TM6 S 293 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 425 - s17s18 E 283 C.s17s18.09
Van-der-waals C-term P 425 - s17s18 E 283 C.s17s18.09
Polar C-term C 428 - S16 C 251 C.S16.05
Hydrophobic C-term C 428 - S16 C 251 C.S16.05
Van-der-waals C-term C 428 - S16 C 251 C.S16.05
Polar C-term R 395 - s6h1 D 93 N.s6h1.07
Hydrophobic C-term R 395 - s6h1 D 93 N.s6h1.07
Van-der-waals C-term R 395 - s6h1 D 93 N.s6h1.07
Hydrophobic C-term P 425 - S16 M 255 C.S16.09
Hydrophobic C-term W 398 - s7s8 P 121 N.s7s8.04
Van-der-waals C-term W 398 - s7s8 P 121 N.s7s8.04
Ionic TM4 R 157 4x38 s8s9 E 134 N.s8s9.05
Polar TM4 R 157 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 157 4x38 s8s9 E 134 N.s8s9.05
Polar C-term H 390 - S5 R 52 N.S5.01
Hydrophobic C-term P 401 - s3s4 L 33 N.s3s4.04
Van-der-waals C-term P 401 - s3s4 L 33 N.s3s4.04
Hydrophobic TM4 R 157 4x38 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 R 157 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic TM7 F 355 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 F 355 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 G 156 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 G 156 - s8s9 T 136 N.s8s9.07
Hydrophobic TM2 R 80 2x37 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 R 80 2x37 s5s6 D 69 N.s5s6.06
Polar ICL1 R 79 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 R 79 - s5s6 R 65 N.s5s6.02
Polar C-term R 397 - s7s8 E 118 N.s7s8.01
Hydrophobic C-term R 397 - s7s8 E 118 N.s7s8.01
Van-der-waals C-term R 397 - s7s8 E 118 N.s7s8.01
Hydrophobic TM6 M 296 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 296 6x36 s5s6 L 71 N.s5s6.08
Polar C-term E 431 - S16 Q 248 C.S16.02
Hydrophobic C-term E 431 - S16 Q 248 C.S16.02
Van-der-waals C-term E 431 - S16 Q 248 C.S16.02
Polar ICL2 H 155 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 H 155 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 155 - s8s9 T 136 N.s8s9.07
Hydrophobic TM2 R 80 2x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 80 2x37 s5s6 V 70 N.s5s6.07
Hydrophobic C-term H 402 - s19s20 E 358 C.s19s20.05
Van-der-waals C-term H 402 - s19s20 E 358 C.s19s20.05
Polar C-term Y 403 - s2s3 K 24 N.s2s3.02
Hydrophobic C-term Y 403 - s2s3 K 24 N.s2s3.02
Van-der-waals C-term Y 403 - s2s3 K 24 N.s2s3.02
Hydrophobic TM6 S 293 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 293 6x33 s5s6 L 71 N.s5s6.08
Polar ICL2 P 154 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 154 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 154 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term W 398 - s3s4 D 32 N.s3s4.03
Van-der-waals C-term W 398 - s3s4 D 32 N.s3s4.03
Hydrophobic C-term L 426 - S16 P 252 C.S16.06
Van-der-waals C-term L 426 - S16 P 252 C.S16.06
Polar C-term H 390 - S5 Y 54 N.S5.03
Aromatic C-term H 390 - S5 Y 54 N.S5.03
Hydrophobic C-term H 390 - S5 Y 54 N.S5.03
Van-der-waals C-term H 390 - S5 Y 54 N.S5.03
Polar C-term Y 403 - S4 D 38 N.S4.02
Polar ICL2 H 155 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 H 155 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 H 155 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term H 404 - s19s20 E 358 C.s19s20.05
Van-der-waals C-term H 404 - s19s20 E 358 C.s19s20.05
Hydrophobic C-term H 404 - s19s20 E 359 C.s19s20.06
Van-der-waals C-term P 399 - s3s4 P 36 N.s3s4.07
Hydrophobic ICL1 P 73 - s20c K 403 C.s20c.13
Hydrophobic ICL1 P 77 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 P 77 - s5s6 D 67 N.s5s6.04
Hydrophobic C-term P 401 - s3s4 P 36 N.s3s4.07
Polar C-term Y 403 - s19s20 E 359 C.s19s20.06
Hydrophobic C-term Y 403 - s19s20 E 359 C.s19s20.06
Van-der-waals C-term Y 403 - s19s20 E 359 C.s19s20.06
Polar C-term H 404 - s19s20 K 357 C.s19s20.04
Hydrophobic C-term H 404 - s19s20 K 357 C.s19s20.04
Van-der-waals C-term H 404 - s19s20 K 357 C.s19s20.04
Hydrophobic TM6 A 289 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 289 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 399 - s3s4 L 33 N.s3s4.04
Van-der-waals C-term P 399 - s3s4 L 33 N.s3s4.04
Hydrophobic C-term P 401 - s3s4 D 35 N.s3s4.06
Van-der-waals C-term P 401 - s3s4 D 35 N.s3s4.06
Polar TM6 K 290 6x30 s15s16 F 244 C.s15s16.03
Aromatic TM6 K 290 6x30 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 K 290 6x30 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 K 290 6x30 s15s16 F 244 C.s15s16.03
Polar C-term R 395 - s6h1 E 92 N.s6h1.06
Hydrophobic C-term R 395 - s6h1 E 92 N.s6h1.06
Van-der-waals C-term R 395 - s6h1 E 92 N.s6h1.06
Hydrophobic TM3 R 147 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 147 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic C-term C 428 - s17s18 K 284 C.s17s18.10
Hydrophobic TM6 Q 292 6x32 s5s6 L 73 N.s5s6.10