Beta-arrestin-2 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR150 59.1
Beta-arrestin-2 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM4 P 158 4x39 s8s9 E 135 N.s8s9.05
Polar ICL2 P 154 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 154 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 154 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 A 282 - S6 D 79 N.S6.04
Polar C-term C 428 - S16 C 252 C.S16.05
Hydrophobic C-term C 428 - S16 C 252 C.S16.05
Van-der-waals C-term C 428 - S16 C 252 C.S16.05
Ionic C-term R 422 - s17s18 D 281 C.s17s18.06
Polar C-term R 422 - s17s18 D 281 C.s17s18.06
Van-der-waals C-term R 422 - s17s18 D 281 C.s17s18.06
Polar C-term E 431 - S16 Q 249 C.S16.02
Van-der-waals C-term E 431 - S16 Q 249 C.S16.02
Polar TM3 L 153 3x56 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 L 153 3x56 s5s6 R 66 N.s5s6.02
Aromatic ICL3 R 279 - S6 F 81 N.S6.06
Hydrophobic ICL3 R 279 - S6 F 81 N.S6.06
Van-der-waals ICL3 R 279 - S6 F 81 N.S6.06
Hydrophobic C-term L 426 - S16 P 253 C.S16.06
Hydrophobic TM6 L 286 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 L 286 6x26 S6 F 76 N.S6.01
Polar ICL2 H 155 - S16 Y 250 C.S16.03
Aromatic ICL2 H 155 - S16 Y 250 C.S16.03
Hydrophobic ICL2 H 155 - S16 Y 250 C.S16.03
Van-der-waals ICL2 H 155 - S16 Y 250 C.S16.03
Hydrophobic ICL2 H 155 - S15 I 242 C.S15.14
Van-der-waals ICL2 H 155 - S15 I 242 C.S15.14
Hydrophobic ICL1 K 78 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 K 78 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 R 279 - s7s8 P 121 N.s7s8.03
Van-der-waals ICL3 R 279 - s7s8 P 121 N.s7s8.03
Polar TM5 H 262 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 262 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 262 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 M 82 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 M 82 2x39 s5s6 L 72 N.s5s6.08
Polar C-term S 429 - S16 K 251 C.S16.04
Van-der-waals C-term S 429 - S16 K 251 C.S16.04
Hydrophobic TM3 V 151 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 151 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 147 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 147 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic H8 Q 356 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Q 356 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 K 78 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL1 K 78 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL1 P 77 - s20c D 402 C.s20c.12
Hydrophobic C-term F 434 - s15s16 S 246 C.s15s16.04
Hydrophobic TM6 K 290 6x30 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 K 290 6x30 s15s16 F 245 C.s15s16.03
Polar TM6 K 290 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 290 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM4 P 158 4x39 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 L 286 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 L 286 6x26 S6 R 77 N.S6.02
Hydrophobic ICL2 P 154 - S5 Y 64 N.S5.12
Van-der-waals ICL2 P 154 - S5 Y 64 N.S5.12
Hydrophobic TM6 L 286 6x26 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 L 286 6x26 s15s16 F 245 C.s15s16.03
Polar C-term C 428 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 428 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 428 - s17s18 R 286 C.s17s18.11
Hydrophobic TM6 L 286 6x26 S6 K 78 N.S6.03
Hydrophobic ICL1 R 79 - s5s6 V 71 N.s5s6.07
Van-der-waals ICL1 R 79 - s5s6 V 71 N.s5s6.07
Polar ICL2 H 155 - S5 Y 64 N.S5.12
Aromatic ICL2 H 155 - S5 Y 64 N.S5.12
Hydrophobic ICL2 H 155 - S5 Y 64 N.S5.12
Van-der-waals ICL2 H 155 - S5 Y 64 N.S5.12
Hydrophobic TM6 K 290 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 290 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic C-term C 428 - s17s18 K 285 C.s17s18.10
Hydrophobic C-term F 434 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term F 434 - s15s16 T 247 C.s15s16.05
Ionic ICL1 K 78 - s5s6 E 67 N.s5s6.03
Polar ICL1 K 78 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 K 78 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 78 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 P 154 - s5s6 L 69 N.s5s6.05
Polar TM6 A 289 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 A 289 6x29 s5s6 L 74 N.s5s6.10
Polar TM6 A 285 6x25 S6 R 77 N.S6.02
Polar ICL1 K 78 - s8s9 G 138 N.s8s9.08
Hydrophobic ICL1 K 78 - s8s9 G 138 N.s8s9.08
Van-der-waals ICL1 K 78 - s8s9 G 138 N.s8s9.08
Hydrophobic C-term C 428 - S16 K 251 C.S16.04
Van-der-waals C-term C 428 - S16 K 251 C.S16.04
Hydrophobic C-term S 432 - S16 A 248 C.S16.01
Ionic C-term E 431 - S16 K 251 C.S16.04
Polar C-term E 431 - S16 K 251 C.S16.04
Hydrophobic C-term E 431 - S16 K 251 C.S16.04
Van-der-waals C-term E 431 - S16 K 251 C.S16.04
Polar ICL1 K 78 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 K 78 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 78 - s8s9 T 137 N.s8s9.07
Hydrophobic C-term P 425 - s17s18 K 285 C.s17s18.10
Van-der-waals C-term P 425 - s17s18 K 285 C.s17s18.10
Hydrophobic C-term C 428 - s17s18 G 287 C.s17s18.12
Hydrophobic C-term L 426 - S16 Q 256 C.S16.09
Van-der-waals C-term L 426 - S16 Q 256 C.S16.09
Hydrophobic ICL2 H 155 - S8 L 130 N.S8.03
Van-der-waals ICL2 H 155 - S8 L 130 N.S8.03
Polar ICL2 G 156 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 G 156 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 G 156 - s5s6 R 66 N.s5s6.02
Polar ICL1 K 78 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 K 78 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 K 78 - s5s6 D 68 N.s5s6.04
Polar TM6 S 293 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 S 293 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 293 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 H 155 - s5s6 R 66 N.s5s6.02
Polar C-term C 430 - S16 Y 250 C.S16.03
Hydrophobic C-term C 430 - S16 Y 250 C.S16.03
Van-der-waals C-term C 430 - S16 Y 250 C.S16.03
Hydrophobic TM6 A 289 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 A 289 6x29 s5s6 G 73 N.s5s6.09
Polar C-term A 433 - s15s16 T 247 C.s15s16.05
Polar ICL1 K 78 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL1 K 78 - s8s9 K 139 N.s8s9.09
Polar ICL2 H 155 - S9 C 141 N.S9.01
Hydrophobic ICL2 H 155 - S9 C 141 N.S9.01
Van-der-waals ICL2 H 155 - S9 C 141 N.S9.01
Hydrophobic TM6 S 293 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 S 293 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 H 155 - s8s9 A 140 N.s8s9.10
Hydrophobic ICL2 H 155 - s8s9 A 140 N.s8s9.10
Polar ICL1 P 77 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 P 77 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 P 77 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 A 282 - S6 I 82 N.S6.07
Van-der-waals ICL3 A 282 - S6 I 82 N.S6.07
Hydrophobic TM3 A 150 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 150 3x53 s5s6 L 69 N.s5s6.05