Beta-arrestin-2 - GPR151 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR151 66.5
Beta-arrestin-2 77.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term E 387 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term E 387 - s17s18 N 312 C.s17s18.37
Hydrophobic H8 E 312 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 E 312 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic C-term W 390 - s17s18 K 313 C.s17s18.38
Van-der-waals C-term W 390 - s17s18 K 313 C.s17s18.38
Hydrophobic C-term P 406 - S16 K 251 C.S16.04
Hydrophobic TM3 Y 139 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 Y 139 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 S 245 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic C-term W 390 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term W 390 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term R 393 - s15s16 T 247 C.s15s16.05
Polar TM3 Y 139 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 Y 139 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 Y 139 3x53 s5s6 R 66 N.s5s6.02
Polar ICL2 A 144 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 A 144 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 A 144 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic C-term V 386 - s17s18 V 315 C.s17s18.40
Van-der-waals C-term V 386 - s17s18 V 315 C.s17s18.40
Hydrophobic TM6 N 238 6x23 S6 F 76 N.S6.01
Polar C-term E 408 - S16 Q 256 C.S16.09
Hydrophobic TM2 I 73 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 I 73 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 N 241 6x26 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 N 241 6x26 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 V 248 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 248 6x33 s5s6 L 74 N.s5s6.10
Polar ICL1 K 69 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL1 K 69 - s8s9 D 136 N.s8s9.06
Polar TM6 R 244 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 244 6x29 s5s6 S 75 N.s5s6.11
Polar TM2 H 74 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 H 74 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 H 74 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 M 251 6x36 s5s6 L 72 N.s5s6.08
Polar C-term K 377 - s6h1 N 93 N.s6h1.06
Hydrophobic C-term K 377 - s6h1 N 93 N.s6h1.06
Polar ICL2 Q 146 34x53 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 Q 146 34x53 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 Q 146 34x53 s15s16 S 246 C.s15s16.04
Polar C-term W 390 - s17s18 N 312 C.s17s18.37
Hydrophobic C-term W 390 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term W 390 - s17s18 N 312 C.s17s18.37
Hydrophobic C-term I 380 - S6 F 81 N.S6.06
Van-der-waals C-term I 380 - S6 F 81 N.S6.06
Hydrophobic ICL2 A 144 34x51 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 144 34x51 s15s16 F 245 C.s15s16.03
Polar C-term R 393 - s15s16 C 243 C.s15s16.01
Hydrophobic C-term R 393 - s15s16 C 243 C.s15s16.01
Van-der-waals C-term W 407 - s8s9 E 135 N.s8s9.05
Polar H8 E 312 8x49 s5s6 V 71 N.s5s6.07
Hydrophobic H8 E 312 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 E 312 8x49 s5s6 V 71 N.s5s6.07
Polar ICL2 P 143 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic TM1 N 64 1x60 s5s6 V 71 N.s5s6.07
Van-der-waals TM1 N 64 1x60 s5s6 V 71 N.s5s6.07
Polar TM2 S 71 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 71 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 71 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 146 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 146 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL1 G 68 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 G 68 - s5s6 E 67 N.s5s6.03
Ionic C-term R 393 - s17s18 E 314 C.s17s18.39
Polar C-term R 393 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term R 393 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term R 393 - s17s18 E 314 C.s17s18.39
Hydrophobic TM6 V 248 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 248 6x33 s5s6 L 72 N.s5s6.08
Polar H8 S 310 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic H8 S 310 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 375 - s6h1 N 93 N.s6h1.06
Hydrophobic TM6 R 240 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 R 240 6x25 S6 R 77 N.S6.02
Hydrophobic C-term W 390 - s17s18 V 315 C.s17s18.40
Van-der-waals C-term W 390 - s17s18 V 315 C.s17s18.40
Polar ICL3 Q 237 - s17s18 N 312 C.s17s18.37
Van-der-waals ICL3 Q 237 - s17s18 N 312 C.s17s18.37
Polar ICL2 K 145 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 K 145 34x52 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 145 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic C-term T 375 - s6h1 P 92 N.s6h1.04
Van-der-waals C-term T 375 - s6h1 P 92 N.s6h1.04
Polar ICL1 K 67 - s20c Y 404 C.s20c.14
Hydrophobic C-term E 408 - S16 P 253 C.S16.06
Van-der-waals C-term E 408 - S16 P 253 C.S16.06
Polar ICL2 Q 146 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 Q 146 34x53 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 Q 146 34x53 s8s9 T 137 N.s8s9.07
Polar ICL1 K 69 - s8s9 P 134 N.s8s9.04
Hydrophobic ICL1 K 69 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL1 K 69 - s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 S 148 34x55 s8s9 T 137 N.s8s9.07
Polar ICL3 Q 237 - S6 K 78 N.S6.03
Hydrophobic ICL3 Q 237 - S6 K 78 N.S6.03
Van-der-waals ICL3 Q 237 - S6 K 78 N.S6.03
Hydrophobic ICL2 P 143 34x50 s15s16 F 245 C.s15s16.03
Polar C-term V 386 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term V 386 - s17s18 N 312 C.s17s18.37
Ionic C-term E 408 - S15 R 237 C.S15.09
Polar C-term E 408 - S15 R 237 C.S15.09
Van-der-waals C-term E 408 - S15 R 237 C.S15.09
Polar ICL1 K 69 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 69 - s8s9 E 135 N.s8s9.05
Hydrophobic C-term P 404 - S16 Q 249 C.S16.02
Hydrophobic H8 E 312 8x49 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 I 77 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic TM1 L 61 1x57 s5s6 V 71 N.s5s6.07
Polar ICL2 Q 146 34x53 S5 Y 64 N.S5.12
Hydrophobic TM6 N 241 6x26 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 N 241 6x26 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 146 34x53 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 Q 146 34x53 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 Q 146 34x53 s8s9 G 138 N.s8s9.08
Hydrophobic C-term P 404 - S16 A 248 C.S16.01
Polar TM6 R 244 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 244 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 244 6x29 s5s6 G 73 N.s5s6.09
Polar H8 F 313 8x50 s5s6 V 71 N.s5s6.07
Hydrophobic H8 F 313 8x50 s5s6 V 71 N.s5s6.07
Polar ICL2 A 144 34x51 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 144 34x51 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 R 240 6x25 S6 F 76 N.S6.01
Polar ICL1 K 69 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 69 - s5s6 E 67 N.s5s6.03
Hydrophobic TM6 R 244 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 R 244 6x29 s5s6 L 74 N.s5s6.10
Ionic C-term D 403 - S16 K 251 C.S16.04
Polar C-term D 403 - S16 K 251 C.S16.04
Hydrophobic C-term D 403 - S16 K 251 C.S16.04
Van-der-waals C-term D 403 - S16 K 251 C.S16.04
Polar TM2 H 74 2x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 H 74 2x40 s5s6 L 72 N.s5s6.08
Polar H8 S 310 8x47 s5s6 G 73 N.s5s6.09
Polar C-term E 376 - s6h1 N 93 N.s6h1.06
Hydrophobic C-term E 376 - s6h1 N 93 N.s6h1.06
Van-der-waals C-term E 376 - s6h1 N 93 N.s6h1.06
Hydrophobic C-term F 389 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term F 389 - s17s18 E 314 C.s17s18.39
Hydrophobic TM6 N 241 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 N 241 6x26 S6 F 76 N.S6.01
Polar TM2 H 74 2x40 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 H 74 2x40 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 H 74 2x40 s5s6 D 68 N.s5s6.04
Polar H8 S 310 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 S 310 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 N 238 6x23 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 N 238 6x23 s15s16 F 245 C.s15s16.03
Hydrophobic C-term F 389 - s17s18 N 312 C.s17s18.37
Van-der-waals C-term F 389 - s17s18 N 312 C.s17s18.37
Hydrophobic TM2 H 74 2x40 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 H 74 2x40 s5s6 E 67 N.s5s6.03