Beta-arrestin-1 - GPR156 complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR156 46.6
Beta-arrestin-1 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.7
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 F 149 3x58 s5s6 L 73 N.s5s6.10
Hydrophobic C-term F 332 - s5s6 G 64 N.s5s6.01
Hydrophobic TM4 K 161 4x28 s5s6 V 70 N.s5s6.07
Hydrophobic C-term P 351 - S16 Y 249 C.S16.03
Van-der-waals C-term P 351 - S16 Y 249 C.S16.03
Polar C-term R 352 - S16 Q 248 C.S16.02
Van-der-waals C-term R 352 - S16 Q 248 C.S16.02
Polar C-term C 349 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term C 349 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term C 349 - s17s18 R 285 C.s17s18.11
Polar C-term N 336 - s8s9 D 135 N.s8s9.06
Hydrophobic C-term N 336 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term N 336 - s8s9 D 135 N.s8s9.06
Hydrophobic H8 A 329 8x56 s15s16 N 245 C.s15s16.04
Van-der-waals H8 A 329 8x56 s15s16 N 245 C.s15s16.04
Hydrophobic C-term F 332 - s8s9 G 137 N.s8s9.08
Van-der-waals C-term F 332 - s8s9 G 137 N.s8s9.08
Polar ICL2 K 156 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 K 156 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 156 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term C 349 - s17s18 K 284 C.s17s18.10
Polar C-term T 334 - s8s9 D 135 N.s8s9.06
Van-der-waals C-term T 334 - s8s9 D 135 N.s8s9.06
Hydrophobic H8 I 325 8x52 s15s16 F 244 C.s15s16.03
Van-der-waals H8 I 325 8x52 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 F 149 3x58 s5s6 L 71 N.s5s6.08
Ionic C-term D 807 - S6 K 77 N.S6.03
Polar C-term D 807 - S6 K 77 N.S6.03
Hydrophobic C-term D 807 - S6 K 77 N.S6.03
Van-der-waals C-term D 807 - S6 K 77 N.S6.03
Ionic C-term E 346 - S18 K 326 C.S18.10
Polar C-term E 346 - S18 K 326 C.S18.10
Hydrophobic C-term E 346 - S18 K 326 C.S18.10
Van-der-waals C-term E 346 - S18 K 326 C.S18.10
Hydrophobic ICL3 V 254 - s5s6 L 73 N.s5s6.10
Hydrophobic H8 M 328 8x55 S6 F 75 N.S6.01
Hydrophobic ICL1 M 82 12x52 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 R 157 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 157 - s5s6 D 67 N.s5s6.04
Polar ICL1 R 78 12x48 s5s6 T 74 N.s5s6.11
Van-der-waals ICL1 R 78 12x48 s5s6 T 74 N.s5s6.11
Hydrophobic ICL1 M 82 12x52 s5s6 L 73 N.s5s6.10
Van-der-waals ICL1 M 82 12x52 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 351 - S16 Q 248 C.S16.02
Van-der-waals C-term P 351 - S16 Q 248 C.S16.02
Hydrophobic ICL2 I 160 - s5s6 V 70 N.s5s6.07
Van-der-waals ICL2 R 152 - s8s9 G 137 N.s8s9.08
Hydrophobic TM3 V 148 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 148 3x57 s5s6 L 68 N.s5s6.05
Polar C-term T 334 - s8s9 E 134 N.s8s9.05
Hydrophobic C-term T 334 - s8s9 E 134 N.s8s9.05
Van-der-waals C-term T 334 - s8s9 E 134 N.s8s9.05
Hydrophobic C-term F 332 - s5s6 T 74 N.s5s6.11
Hydrophobic C-term E 347 - S16 P 252 C.S16.06
Van-der-waals C-term E 347 - S16 P 252 C.S16.06
Ionic C-term K 810 - s9s10 E 155 N.s9s10.07
Hydrophobic C-term F 805 - S6 L 79 N.S6.05
Polar TM3 R 144 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 I 159 - s5s6 V 70 N.s5s6.07
Van-der-waals ICL2 I 159 - s5s6 V 70 N.s5s6.07
Hydrophobic C-term F 805 - s17s18 I 314 C.s17s18.40
Van-der-waals C-term F 805 - s17s18 I 314 C.s17s18.40
Polar C-term C 349 - S16 C 251 C.S16.05
Hydrophobic C-term C 349 - S16 C 251 C.S16.05
Van-der-waals C-term C 349 - S16 C 251 C.S16.05
Hydrophobic C-term F 332 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term F 332 - s5s6 L 73 N.s5s6.10
Hydrophobic C-term F 805 - S6 K 77 N.S6.03
Hydrophobic ICL2 R 152 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 152 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL1 M 82 12x52 s5s6 L 71 N.s5s6.08
Van-der-waals ICL1 M 82 12x52 s5s6 L 71 N.s5s6.08
Polar ICL2 R 152 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 R 152 - s8s9 P 133 N.s8s9.04
Hydrophobic C-term W 796 - s3s4 D 32 N.s3s4.03
Van-der-waals C-term W 796 - s3s4 D 32 N.s3s4.03
Ionic ICL2 R 157 - s5s6 E 66 N.s5s6.03
Polar ICL2 R 157 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 R 157 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL2 R 157 - s5s6 E 66 N.s5s6.03
Aromatic C-term F 332 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term F 332 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term F 332 - s15s16 F 244 C.s15s16.03
Hydrophobic TM3 V 148 3x57 s5s6 D 67 N.s5s6.04
Ionic H8 R 326 8x53 s17s18 E 313 C.s17s18.39
Polar H8 R 326 8x53 s17s18 E 313 C.s17s18.39
Van-der-waals H8 R 326 8x53 s17s18 E 313 C.s17s18.39
Ionic ICL2 R 157 - s20c E 405 C.s20c.15
Polar ICL2 R 157 - s20c E 405 C.s20c.15
Hydrophobic ICL2 R 157 - s20c E 405 C.s20c.15
Van-der-waals ICL2 R 157 - s20c E 405 C.s20c.15
Hydrophobic C-term C 349 - S16 P 252 C.S16.06
Van-der-waals C-term C 349 - S16 P 252 C.S16.06
Polar ICL2 R 152 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 152 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 152 - s8s9 E 134 N.s8s9.05
Hydrophobic H8 A 329 8x56 s15s16 F 244 C.s15s16.03
Van-der-waals H8 A 329 8x56 s15s16 F 244 C.s15s16.03
Hydrophobic H8 M 328 8x55 s15s16 F 244 C.s15s16.03
Van-der-waals H8 M 328 8x55 s15s16 F 244 C.s15s16.03
Ionic C-term E 374 - s18s19 R 331 C.s18s19.02
Polar C-term E 374 - s18s19 R 331 C.s18s19.02
Van-der-waals C-term E 374 - s18s19 R 331 C.s18s19.02
Hydrophobic C-term F 332 - s5s6 L 68 N.s5s6.05
Polar ICL2 V 153 - s5s6 R 65 N.s5s6.02
Ionic C-term E 346 - S15 R 236 C.S15.09
Polar C-term E 346 - S15 R 236 C.S15.09
Hydrophobic C-term E 346 - S15 R 236 C.S15.09
Van-der-waals C-term E 346 - S15 R 236 C.S15.09
Hydrophobic C-term C 349 - S16 K 250 C.S16.04
Van-der-waals C-term C 349 - S16 K 250 C.S16.04
Hydrophobic H8 I 325 8x52 S6 F 75 N.S6.01
Hydrophobic C-term H 350 - S16 Y 249 C.S16.03
Hydrophobic ICL2 I 159 - s5s6 D 67 N.s5s6.04
Polar ICL2 P 154 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 154 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term Q 375 - s11s12 L 191 C.s11s12.02
Van-der-waals C-term Q 375 - s11s12 L 191 C.s11s12.02
Hydrophobic TM3 R 144 3x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 144 3x53 s5s6 L 71 N.s5s6.08
Hydrophobic C-term E 347 - S16 M 255 C.S16.09
Van-der-waals C-term E 347 - S16 M 255 C.S16.09
Hydrophobic C-term E 346 - S16 P 252 C.S16.06
Van-der-waals C-term E 346 - S16 P 252 C.S16.06
Polar ICL2 R 157 - s20c E 404 C.s20c.14
Van-der-waals ICL2 R 157 - s20c E 404 C.s20c.14
Hydrophobic ICL2 V 158 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 V 158 - s5s6 D 67 N.s5s6.04
Hydrophobic C-term Y 331 - s5s6 L 73 N.s5s6.10
Van-der-waals C-term Y 331 - s5s6 L 73 N.s5s6.10
Polar C-term N 336 - s8s9 K 138 N.s8s9.09
Van-der-waals C-term N 336 - s8s9 K 138 N.s8s9.09
Hydrophobic TM3 F 149 3x58 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 F 149 3x58 s5s6 L 68 N.s5s6.05
Polar ICL2 R 152 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 152 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 152 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 V 254 - s5s6 L 71 N.s5s6.08
Ionic C-term E 346 - S18 K 324 C.S18.08
Polar C-term E 346 - S18 K 324 C.S18.08
Van-der-waals C-term E 346 - S18 K 324 C.S18.08
Aromatic C-term F 332 - S5 Y 63 N.S5.12
Hydrophobic C-term F 332 - S5 Y 63 N.S5.12
Van-der-waals C-term F 332 - S5 Y 63 N.S5.12
Hydrophobic ICL2 D 155 - s20c D 402 C.s20c.12
Van-der-waals ICL2 D 155 - s20c D 402 C.s20c.12