Beta-arrestin-1 - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR157 75.1
Beta-arrestin-1 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals ICL1 L 42 12x50 s5s6 D 69 N.s5s6.06
Ionic TM2 R 47 2x40 s5s6 D 69 N.s5s6.06
Polar TM2 R 47 2x40 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 R 47 2x40 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 R 47 2x40 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 L 104 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 104 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 R 113 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 113 - s15s16 T 246 C.s15s16.05
Hydrophobic TM6 M 222 6x32 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 M 222 6x32 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 A 46 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 A 46 2x39 s5s6 V 70 N.s5s6.07
Polar ICL2 R 113 - s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 R 113 - s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 R 113 - s15s16 L 243 C.s15s16.02
Hydrophobic TM7 F 279 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 279 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 L 50 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 50 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic ICL1 R 43 12x51 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 I 108 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 108 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic H8 T 283 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 T 283 8x47 s5s6 D 69 N.s5s6.06
Ionic H8 R 284 8x48 s20c E 407 C.s20c.17
Polar H8 R 284 8x48 s20c E 407 C.s20c.17
Hydrophobic H8 R 284 8x48 s20c E 407 C.s20c.17
Van-der-waals H8 R 284 8x48 s20c E 407 C.s20c.17
Polar H8 T 283 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 T 283 8x47 s5s6 V 70 N.s5s6.07
Polar TM3 Y 103 3x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 Y 103 3x49 s5s6 D 67 N.s5s6.04
Polar TM2 S 44 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 S 44 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 44 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 A 46 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 A 46 2x39 s5s6 D 67 N.s5s6.04
Ionic TM6 H 219 6x29 S6 D 78 N.S6.04
Polar TM6 H 219 6x29 S6 D 78 N.S6.04
Hydrophobic TM6 H 219 6x29 S6 D 78 N.S6.04
Van-der-waals TM6 H 219 6x29 S6 D 78 N.S6.04
Polar ICL2 R 113 - s15s16 C 242 C.s15s16.01
Hydrophobic ICL2 R 113 - s15s16 C 242 C.s15s16.01
Van-der-waals ICL2 R 113 - s15s16 C 242 C.s15s16.01
Hydrophobic TM6 I 230 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 230 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 R 47 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 47 2x40 s5s6 V 70 N.s5s6.07
Polar ICL2 R 113 - s15s16 F 244 C.s15s16.03
Aromatic ICL2 R 113 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 113 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 113 - s15s16 F 244 C.s15s16.03
Polar TM3 S 107 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 S 107 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 S 107 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 L 104 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 L 104 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic H8 T 283 8x47 s5s6 G 72 N.s5s6.09
Polar ICL2 R 113 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 113 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 113 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 108 3x54 s5s6 L 73 N.s5s6.10
Polar ICL1 L 42 12x50 s5s6 E 66 N.s5s6.03
Hydrophobic ICL1 L 42 12x50 s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 L 42 12x50 s5s6 E 66 N.s5s6.03
Ionic H8 R 284 8x48 s20c E 405 C.s20c.15
Polar H8 R 284 8x48 s20c E 405 C.s20c.15
Hydrophobic H8 R 284 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 R 284 8x48 s20c E 405 C.s20c.15
Polar TM2 S 44 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 S 44 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 S 44 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM7 F 279 7x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 F 279 7x53 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 R 45 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 D 41 12x49 s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 D 41 12x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 A 223 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 223 6x33 s5s6 L 73 N.s5s6.10
Polar TM6 K 226 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 226 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 K 226 6x36 s5s6 L 71 N.s5s6.08