Beta-arrestin-1 - GPR161 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR161 61.5
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 253 - S6 V 81 N.S6.07
Van-der-waals ICL3 R 253 - S6 V 81 N.S6.07
Ionic H8 K 329 8x48 s5s6 D 69 N.s5s6.06
Polar H8 K 329 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 329 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 329 8x48 s5s6 D 69 N.s5s6.06
Polar C-term S 401 - s17s18 R 285 C.s17s18.11
Hydrophobic TM5 A 215 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 215 5x65 s5s6 L 73 N.s5s6.10
Polar TM6 N 264 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 I 272 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 407 - S16 A 247 C.S16.01
Ionic C-term D 404 - S15 R 236 C.S15.09
Hydrophobic C-term D 410 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL3 F 256 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 M 133 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 M 133 34x51 S9 C 140 N.S9.01
Hydrophobic C-term M 406 - S16 K 250 C.S16.04
Van-der-waals C-term M 406 - S16 K 250 C.S16.04
Hydrophobic C-term T 403 - S16 Y 249 C.S16.03
Hydrophobic TM3 V 129 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic C-term M 405 - S16 Y 249 C.S16.03
Van-der-waals C-term M 405 - S16 Y 249 C.S16.03
Hydrophobic TM3 V 129 3x54 S6 F 75 N.S6.01
Hydrophobic TM5 V 222 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 V 222 5x72 S6 R 76 N.S6.02
Polar C-term T 403 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term T 403 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL3 V 228 - S6 F 80 N.S6.06
Van-der-waals ICL3 V 228 - S6 F 80 N.S6.06
Hydrophobic ICL2 M 133 34x51 S5 Y 63 N.S5.12
Hydrophobic TM3 A 128 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 128 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic C-term T 403 - S16 K 250 C.S16.04
Van-der-waals C-term T 403 - S16 K 250 C.S16.04
Hydrophobic TM3 R 125 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic C-term M 405 - S16 A 247 C.S16.01
Hydrophobic TM5 K 221 5x71 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 221 5x71 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 T 271 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term M 405 - S16 Q 248 C.S16.02
Van-der-waals C-term M 405 - S16 Q 248 C.S16.02
Hydrophobic ICL3 V 227 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 227 - S6 D 78 N.S6.04
Polar ICL3 E 231 - S6 N 83 N.S6.09
Van-der-waals ICL3 E 231 - S6 N 83 N.S6.09
Polar C-term D 404 - S16 K 250 C.S16.04
Hydrophobic C-term D 404 - S16 K 250 C.S16.04
Van-der-waals C-term D 404 - S16 K 250 C.S16.04
Polar TM6 A 268 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 268 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic C-term G 402 - S16 P 252 C.S16.06
Van-der-waals C-term G 402 - S16 P 252 C.S16.06
Hydrophobic C-term S 401 - s17s18 K 284 C.s17s18.10
Polar ICL3 R 253 - S6 N 83 N.S6.09
Hydrophobic ICL3 R 253 - S6 N 83 N.S6.09
Van-der-waals ICL3 R 253 - S6 N 83 N.S6.09
Hydrophobic ICL2 M 133 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 M 133 34x51 S15 I 241 C.S15.14
Hydrophobic ICL3 V 227 - S6 F 80 N.S6.06
Hydrophobic C-term P 348 - s20c G 411 C.s20c.21
Hydrophobic C-term L 408 - S16 Q 248 C.S16.02
Van-der-waals C-term L 408 - S16 Q 248 C.S16.02
Polar ICL2 M 133 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 M 133 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 M 133 34x51 S16 Y 249 C.S16.03
Hydrophobic TM5 Y 208 5x58 s5s6 L 71 N.s5s6.08
Ionic TM5 K 221 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 K 221 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 K 221 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 T 226 5x76 S6 K 77 N.S6.03
Hydrophobic TM5 T 226 5x76 S6 K 77 N.S6.03
Van-der-waals TM5 T 226 5x76 S6 K 77 N.S6.03
Hydrophobic ICL2 M 133 34x51 S16 A 247 C.S16.01
Hydrophobic TM5 V 222 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 V 222 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 V 227 - S6 L 79 N.S6.05
Hydrophobic TM3 V 129 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 V 129 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 211 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 I 211 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 125 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 125 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 A 268 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 K 267 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 267 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM2 T 60 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 T 60 2x37 s8s9 T 136 N.s8s9.07
Polar C-term R 352 - s20c S 412 C.s20c.22
Hydrophobic TM3 V 129 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 129 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 P 136 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 P 136 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 P 132 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 132 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL3 V 230 - S6 F 80 N.S6.06
Hydrophobic TM5 K 218 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 K 218 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 K 218 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 K 218 5x68 S6 F 75 N.S6.01
Polar ICL2 Y 135 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Y 135 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Y 135 34x53 s5s6 R 65 N.s5s6.02
Polar ICL3 V 228 - S6 L 79 N.S6.05
Van-der-waals ICL3 V 228 - S6 L 79 N.S6.05
Ionic H8 K 329 8x48 s20c E 405 C.s20c.15
Polar C-term L 408 - s15s16 T 246 C.s15s16.05
Hydrophobic C-term L 408 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term L 408 - s15s16 T 246 C.s15s16.05
Polar TM5 K 218 5x68 S5 Y 63 N.S5.12
Van-der-waals TM5 K 218 5x68 S5 Y 63 N.S5.12
Polar C-term T 403 - S16 C 251 C.S16.05
Hydrophobic C-term T 403 - S16 C 251 C.S16.05
Van-der-waals C-term T 403 - S16 C 251 C.S16.05
Ionic TM6 K 267 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 K 267 6x32 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 267 6x32 s5s6 D 69 N.s5s6.06
Polar C-term M 406 - S16 Q 248 C.S16.02
Van-der-waals C-term M 406 - S16 Q 248 C.S16.02
Hydrophobic TM2 L 61 2x38 s8s9 E 134 N.s8s9.05
Hydrophobic C-term L 408 - S15 D 240 C.S15.13
Polar TM4 G 141 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 G 141 4x39 s8s9 E 134 N.s8s9.05
Polar TM3 L 130 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic C-term T 403 - s17s18 G 286 C.s17s18.12
Polar TM6 T 271 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 271 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 271 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 328 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 407 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term L 407 - s15s16 T 246 C.s15s16.05
Polar C-term R 354 - s20c Q 394 C.s20c.04
Van-der-waals C-term R 354 - s20c Q 394 C.s20c.04
Hydrophobic C-term L 407 - s15s16 N 245 C.s15s16.04