Beta-arrestin-2 - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR171 82.0
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic H8 K 290 8x48 s5s6 D 70 N.s5s6.06
Polar H8 K 290 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 K 290 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 K 290 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 Y 123 34x54 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 Y 123 34x54 s8s9 P 134 N.s8s9.04
Polar ICL2 C 120 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 C 120 34x51 S16 Y 250 C.S16.03
Ionic ICL2 R 124 34x55 s8s9 E 135 N.s8s9.05
Polar ICL2 R 124 34x55 s8s9 E 135 N.s8s9.05
Polar ICL2 Y 123 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 Y 123 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 Y 123 34x54 s8s9 G 138 N.s8s9.08
Polar H8 K 290 8x48 s20c Q 407 C.s20c.17
Hydrophobic H8 K 290 8x48 s20c Q 407 C.s20c.17
Van-der-waals H8 K 290 8x48 s20c Q 407 C.s20c.17
Hydrophobic TM3 Q 115 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 Q 115 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 206 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 206 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 116 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 I 122 34x53 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 I 122 34x53 s8s9 T 137 N.s8s9.07
Polar TM6 N 224 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 N 224 6x36 s5s6 V 71 N.s5s6.07
Polar TM6 N 214 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 N 214 6x26 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 R 112 3x50 s5s6 L 72 N.s5s6.08
Polar TM3 H 118 3x56 S5 Y 64 N.S5.12
Aromatic TM3 H 118 3x56 S5 Y 64 N.S5.12
Hydrophobic TM3 H 118 3x56 S5 Y 64 N.S5.12
Van-der-waals TM3 H 118 3x56 S5 Y 64 N.S5.12
Aromatic TM3 H 118 3x56 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 H 118 3x56 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 H 118 3x56 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 L 116 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 116 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 Y 123 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Y 123 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Y 123 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 C 120 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 C 120 34x51 S16 A 248 C.S16.01
Hydrophobic H8 S 289 8x47 s5s6 V 71 N.s5s6.07
Polar TM3 H 118 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 H 118 3x56 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 H 118 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 H 118 3x56 s8s9 K 139 N.s8s9.09
Hydrophobic TM6 N 214 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 N 214 6x26 S6 R 77 N.S6.02
Polar ICL2 C 120 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 C 120 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 C 120 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 S 119 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 119 34x50 s8s9 T 137 N.s8s9.07
Ionic TM2 R 47 2x37 s5s6 D 68 N.s5s6.04
Polar TM2 R 47 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 47 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 47 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 E 127 4x38 s8s9 P 134 N.s8s9.04
Van-der-waals TM4 E 127 4x38 s8s9 P 134 N.s8s9.04
Hydrophobic TM6 A 221 6x33 s5s6 L 74 N.s5s6.10
Polar C-term A 319 - S1 K 11 N.S1.03
Hydrophobic C-term A 319 - S1 K 11 N.S1.03
Van-der-waals C-term A 319 - S1 K 11 N.S1.03
Hydrophobic ICL2 Y 123 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 Y 123 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic TM7 L 288 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 288 7x56 s5s6 V 71 N.s5s6.07
Polar TM3 Q 115 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 Q 115 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 Q 115 3x53 s8s9 K 139 N.s8s9.09
Polar TM6 N 217 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 N 217 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 N 217 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic ICL3 N 212 - S6 F 76 N.S6.01
Van-der-waals ICL3 N 212 - S6 F 76 N.S6.01
Polar TM6 A 221 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 221 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 221 6x33 s5s6 L 72 N.s5s6.08
Ionic C-term E 311 - s9s10 R 162 N.s9s10.13
Polar C-term E 311 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term E 311 - s9s10 R 162 N.s9s10.13
Ionic C-term K 312 - s20c D 406 C.s20c.16
Polar C-term K 312 - s20c D 406 C.s20c.16
Polar ICL3 E 213 - S6 D 79 N.S6.04
Polar TM6 N 217 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 V 218 6x30 s5s6 L 74 N.s5s6.10
Polar C-term C 315 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 315 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 315 - s1s2 C 17 N.s1s2.04
Polar ICL2 Y 123 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 123 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 123 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 I 225 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic C-term K 312 - s1s2 P 15 N.s1s2.02
Polar H8 R 293 8x51 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 293 8x51 s5s6 D 70 N.s5s6.06
Polar TM4 E 127 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 E 127 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 E 127 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic C-term A 308 - s9s10 R 162 N.s9s10.13
Hydrophobic ICL2 Y 123 34x54 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 Y 123 34x54 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 N 209 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 N 209 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 K 121 34x52 s8s9 T 137 N.s8s9.07
Polar ICL2 Y 123 34x54 s8s9 G 133 N.s8s9.03
Hydrophobic ICL2 Y 123 34x54 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 Y 123 34x54 s8s9 G 133 N.s8s9.03
Hydrophobic TM6 N 217 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 Y 123 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 Y 123 34x54 s8s9 P 132 N.s8s9.02