Beta-arrestin-2 - GPR174 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR174 76.3
Beta-arrestin-2 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 123 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 123 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 123 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 F 119 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 F 119 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic H8 T 296 8x47 s5s6 G 73 N.s5s6.09
Polar TM3 R 116 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 116 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 116 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM1 F 44 1x57 s5s6 V 71 N.s5s6.07
Polar ICL3 Y 216 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 Y 216 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 Y 216 - s17s18 E 314 C.s17s18.39
Polar ICL2 F 126 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 F 126 34x53 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 F 126 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 125 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 125 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 T 51 1x64 s5s6 E 67 N.s5s6.03
Polar TM1 Y 47 1x60 s5s6 D 68 N.s5s6.04
Hydrophobic TM1 Y 47 1x60 s5s6 D 68 N.s5s6.04
Van-der-waals TM1 Y 47 1x60 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 P 123 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 124 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 124 34x51 S16 A 248 C.S16.01
Polar ICL2 F 124 34x51 S5 Y 64 N.S5.12
Aromatic ICL2 F 124 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 124 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 124 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL1 R 53 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 R 53 - s5s6 R 66 N.s5s6.02
Ionic TM6 E 224 6x29 S6 R 77 N.S6.02
Polar TM6 E 224 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 E 224 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 E 224 6x29 S6 R 77 N.S6.02
Hydrophobic H8 T 296 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 T 296 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM1 T 51 1x64 s5s6 D 68 N.s5s6.04
Van-der-waals TM1 T 51 1x64 s5s6 D 68 N.s5s6.04
Ionic ICL1 R 53 - s5s6 D 68 N.s5s6.04
Polar ICL1 R 53 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 R 53 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 R 53 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 D 128 34x55 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 D 128 34x55 s8s9 P 134 N.s8s9.04
Hydrophobic H8 E 298 8x49 s5s6 V 71 N.s5s6.07
Van-der-waals H8 E 298 8x49 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 123 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 123 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 112 3x46 s5s6 L 72 N.s5s6.08
Polar ICL3 L 222 - S6 D 79 N.S6.04
Hydrophobic ICL3 L 222 - S6 D 79 N.S6.04
Van-der-waals ICL3 L 222 - S6 D 79 N.S6.04
Hydrophobic TM6 I 232 6x37 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 V 55 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 55 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 120 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 120 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 P 123 34x50 s8s9 K 139 N.s8s9.09
Polar ICL2 F 126 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 A 219 - S6 L 80 N.S6.05
Van-der-waals ICL3 A 219 - S6 L 80 N.S6.05
Hydrophobic ICL2 F 124 34x51 s8s9 G 138 N.s8s9.08
Hydrophobic H8 E 298 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 M 218 - S6 K 78 N.S6.03
Van-der-waals ICL3 M 218 - S6 K 78 N.S6.03
Hydrophobic ICL2 F 124 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic ICL3 A 219 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 219 - S6 D 79 N.S6.04
Hydrophobic TM3 R 115 3x49 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 116 3x50 s5s6 L 74 N.s5s6.10
Polar TM3 F 119 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 F 119 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 F 119 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 F 119 3x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 F 119 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 Q 220 - S6 I 82 N.S6.07
Hydrophobic ICL2 F 124 34x51 S9 C 141 N.S9.01
Hydrophobic TM2 M 58 2x43 s5s6 L 72 N.s5s6.08
Ionic ICL2 D 128 34x55 s5s6 R 66 N.s5s6.02
Polar ICL2 D 128 34x55 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 124 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 124 34x51 S16 Y 250 C.S16.03
Polar ICL2 H 127 34x54 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 H 127 34x54 s8s9 E 135 N.s8s9.05
Polar TM6 E 224 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 E 224 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 E 224 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals C-term L 314 - s20c Y 404 C.s20c.14
Hydrophobic H8 T 296 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 T 296 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 F 124 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 F 124 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 F 124 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 F 124 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 124 34x51 S15 I 242 C.S15.14
Polar TM1 Y 47 1x60 s5s6 E 67 N.s5s6.03
Hydrophobic TM1 Y 47 1x60 s5s6 E 67 N.s5s6.03
Van-der-waals TM1 Y 47 1x60 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 M 218 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 M 218 - s17s18 V 315 C.s17s18.40
Hydrophobic TM6 M 231 6x36 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 M 231 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic ICL1 A 54 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 A 54 - s5s6 D 68 N.s5s6.04
Hydrophobic TM6 A 228 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 H 127 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 127 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 H 127 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 F 119 3x53 S6 F 76 N.S6.01
Hydrophobic ICL3 M 218 - S6 L 80 N.S6.05
Hydrophobic ICL1 A 54 - s5s6 L 72 N.s5s6.08
Van-der-waals ICL1 A 54 - s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 120 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 120 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 222 - S6 I 82 N.S6.07
Van-der-waals ICL3 L 222 - S6 I 82 N.S6.07
Ionic H8 R 301 8x52 s5s6 E 67 N.s5s6.03
Polar H8 R 301 8x52 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 M 58 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 M 58 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 124 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 124 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM1 Y 47 1x60 s5s6 V 71 N.s5s6.07
Van-der-waals TM1 Y 47 1x60 s5s6 V 71 N.s5s6.07