S-arrestin - GPR182 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR182 70.9
S-arrestin 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 84 12x50 s8s9 K 145 N.s8s9.09
Polar C-term T 357 - S16 K 261 C.S16.05
Hydrophobic TM3 T 154 3x53 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 T 154 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 259 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 L 259 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic ICL1 R 84 12x50 s8s9 P 140 N.s8s9.04
Van-der-waals ICL1 R 84 12x50 s8s9 P 140 N.s8s9.04
Polar H8 P 325 8x48 s5s6 D 75 N.s5s6.04
Hydrophobic H8 P 325 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals H8 P 325 8x48 s5s6 D 75 N.s5s6.04
Polar H8 H 326 8x49 s8s9 G 144 N.s8s9.08
Hydrophobic H8 H 326 8x49 s8s9 G 144 N.s8s9.08
Van-der-waals H8 H 326 8x49 s8s9 G 144 N.s8s9.08
Ionic ICL3 K 252 - s5s6 E 74 N.s5s6.03
Polar ICL3 K 252 - s5s6 E 74 N.s5s6.03
Van-der-waals ICL3 K 252 - s5s6 E 74 N.s5s6.03
Polar H8 H 326 8x49 s5s6 Q 73 N.s5s6.02
Hydrophobic H8 H 326 8x49 s5s6 Q 73 N.s5s6.02
Van-der-waals H8 H 326 8x49 s5s6 Q 73 N.s5s6.02
Polar C-term C 355 - S16 K 261 C.S16.05
Hydrophobic C-term C 355 - S16 K 261 C.S16.05
Van-der-waals C-term C 355 - S16 K 261 C.S16.05
Polar H8 H 326 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 H 326 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 H 326 8x49 s5s6 D 75 N.s5s6.04
Ionic TM4 H 167 4x39 S16 D 257 C.S16.01
Polar TM4 H 167 4x39 S16 D 257 C.S16.01
Hydrophobic TM6 L 260 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 260 6x37 s5s6 I 79 N.s5s6.08
Polar TM4 Q 166 4x38 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 N 321 7x54 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 N 321 7x54 s5s6 V 78 N.s5s6.07
Polar TM6 H 256 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 H 256 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 L 259 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 259 6x36 s5s6 I 79 N.s5s6.08
Ionic TM3 R 151 3x50 s5s6 D 77 N.s5s6.06
Polar TM3 R 151 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 151 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 151 3x50 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 L 155 3x54 S6 F 83 N.S6.01
Polar TM6 H 256 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 H 256 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 H 256 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic H8 P 325 8x48 s5s6 E 74 N.s5s6.03
Van-der-waals H8 P 325 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 Q 163 34x55 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 Q 163 34x55 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 Y 320 7x53 s5s6 D 77 N.s5s6.06
Polar TM6 Y 263 6x40 s5s6 D 77 N.s5s6.06
Polar ICL1 R 84 12x50 s8s9 A 139 N.s8s9.03
Hydrophobic ICL1 R 84 12x50 s8s9 A 139 N.s8s9.03
Van-der-waals ICL1 R 84 12x50 s8s9 A 139 N.s8s9.03
Hydrophobic TM7 Y 320 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 320 7x53 s5s6 V 78 N.s5s6.07
Ionic ICL1 R 84 12x50 s8s9 D 142 N.s8s9.06
Hydrophobic ICL1 R 84 12x50 s8s9 D 142 N.s8s9.06
Van-der-waals ICL1 R 84 12x50 s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 G 249 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 G 249 - s9s10 E 165 N.s9s10.07
Polar ICL2 R 164 34x56 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 R 164 34x56 s15s16 S 256 C.s15s16.05
Hydrophobic TM7 L 323 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 323 7x56 s5s6 V 78 N.s5s6.07
Polar H8 S 324 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic H8 S 324 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 S 324 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic H8 H 326 8x49 s8s9 S 143 N.s8s9.07
Hydrophobic TM5 L 245 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 245 5x65 s5s6 L 81 N.s5s6.10
Polar ICL2 Q 163 34x55 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 Q 163 34x55 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 Q 163 34x55 s15s16 S 256 C.s15s16.05
Hydrophobic H8 S 324 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 S 324 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 L 319 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 319 7x52 s5s6 V 78 N.s5s6.07
Polar ICL1 R 84 12x50 s8s9 Q 141 N.s8s9.05
Hydrophobic ICL1 R 84 12x50 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 R 84 12x50 s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 H 256 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 H 256 6x33 s5s6 L 81 N.s5s6.10
Polar ICL3 P 251 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 P 251 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 P 251 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 Q 163 34x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM4 Q 166 4x38 s15s16 S 255 C.s15s16.04
Van-der-waals TM6 Y 263 6x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 147 3x46 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 L 147 3x46 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 Q 163 34x55 s15s16 L 253 C.s15s16.02
Hydrophobic ICL3 Q 250 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 Q 250 - s9s10 D 166 N.s9s10.08
Hydrophobic TM2 M 88 2x39 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 M 88 2x39 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 R 151 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 151 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 Q 163 34x55 s15s16 V 252 C.s15s16.01
Hydrophobic ICL2 Q 163 34x55 s15s16 V 252 C.s15s16.01
Van-der-waals ICL2 Q 163 34x55 s15s16 V 252 C.s15s16.01
Hydrophobic TM2 I 92 2x43 s5s6 D 77 N.s5s6.06
Polar ICL3 Q 250 - S6 R 84 N.S6.02
Van-der-waals ICL3 Q 250 - S6 R 84 N.S6.02
Hydrophobic TM3 L 155 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 Y 263 6x40 s5s6 I 79 N.s5s6.08