Beta-arrestin-2 - GPBA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPBA 76.1
Beta-arrestin-2 76.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 120 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 P 120 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 P 120 - s8s9 D 136 N.s8s9.06
Hydrophobic TM6 L 214 6x25 S6 D 79 N.S6.04
Polar TM3 A 113 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 A 113 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM5 V 188 5x61 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 A 192 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 202 5x75 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 L 202 5x75 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 V 206 5x79 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 V 206 5x79 s17s18 V 315 C.s17s18.40
Polar TM5 Q 195 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 195 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 195 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 L 202 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 L 202 5x75 S6 K 78 N.S6.03
Hydrophobic ICL2 L 118 - s8s9 P 132 N.s8s9.02
Polar TM6 R 221 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 221 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 221 6x32 s5s6 G 73 N.s5s6.09
Polar TM5 R 201 5x74 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 L 189 5x62 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 189 5x62 s5s6 L 72 N.s5s6.08
Polar TM5 I 199 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 I 199 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 I 199 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 L 202 5x75 S6 L 80 N.S6.05
Hydrophobic TM5 A 192 5x65 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 199 5x72 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 I 199 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 199 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 P 120 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 P 120 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 118 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 L 118 - s8s9 K 139 N.s8s9.09
Polar H8 R 286 8x49 s5s6 E 67 N.s5s6.03
Polar ICL2 Q 119 - s5s6 R 66 N.s5s6.02
Polar TM5 L 202 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 L 202 5x75 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 L 202 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 A 205 5x78 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 A 205 5x78 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 Q 195 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 Q 195 5x68 S6 F 76 N.S6.01
Hydrophobic ICL2 L 118 - S16 Y 250 C.S16.03
Van-der-waals ICL2 L 118 - S16 Y 250 C.S16.03
Ionic H8 R 286 8x49 s5s6 D 70 N.s5s6.06
Polar H8 R 286 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 286 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 286 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 118 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 L 118 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 P 121 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 121 - s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 202 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 L 202 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic ICL2 L 118 - S8 L 130 N.S8.03
Hydrophobic TM3 V 114 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 L 118 - S15 I 242 C.S15.14
Hydrophobic TM6 L 218 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 218 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 202 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 L 202 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM3 A 113 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 113 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 A 225 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 225 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 117 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 P 117 - s8s9 K 139 N.s8s9.09
Hydrophobic TM3 V 114 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 V 114 3x54 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 V 114 3x54 s5s6 V 71 N.s5s6.07
Polar TM3 R 110 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 110 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 117 - S5 Y 64 N.S5.12
Van-der-waals ICL2 P 117 - S5 Y 64 N.S5.12
Ionic TM5 R 201 5x74 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 201 5x74 s17s18 E 314 C.s17s18.39
Polar H8 R 286 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 R 286 8x49 s5s6 D 68 N.s5s6.04
Polar ICL2 Q 119 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Q 119 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Q 119 - s8s9 D 136 N.s8s9.06