S-arrestin - GPRC5B complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPRC5B 67.7
S-arrestin 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term Y 330 - s10s11 P 190 C.s10s11.07
Polar H8 F 308 8x54 S5 Y 71 N.S5.12
Aromatic H8 F 308 8x54 S5 Y 71 N.S5.12
Hydrophobic H8 F 308 8x54 S5 Y 71 N.S5.12
Van-der-waals H8 F 308 8x54 S5 Y 71 N.S5.12
Polar H8 Y 307 8x53 S16 D 257 C.S16.01
Hydrophobic H8 Y 307 8x53 S16 D 257 C.S16.01
Van-der-waals H8 Y 307 8x53 S16 D 257 C.S16.01
Hydrophobic C-term F 320 - S18 S 330 C.S18.04
Polar H8 Y 307 8x53 s15s16 S 256 C.s15s16.05
Hydrophobic H8 Y 307 8x53 s15s16 S 256 C.s15s16.05
Van-der-waals H8 Y 307 8x53 s15s16 S 256 C.s15s16.05
Polar C-term E 321 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term E 321 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term E 321 - s17s18 R 322 C.s17s18.38
Hydrophobic H8 T 304 8x50 S16 Y 258 C.S16.02
Van-der-waals H8 T 304 8x50 S16 Y 258 C.S16.02
Hydrophobic H8 F 308 8x54 S8 L 136 N.S8.03
Van-der-waals H8 F 308 8x54 S8 L 136 N.S8.03
Hydrophobic C-term F 320 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term F 320 - s17s18 I 316 C.s17s18.32
Hydrophobic C-term L 326 - S19 R 358 C.S19.10
Van-der-waals C-term L 326 - S19 R 358 C.S19.10
Hydrophobic C-term F 320 - S18 V 329 C.S18.03
Polar H8 N 306 8x52 s8s9 D 142 N.s8s9.06
Hydrophobic H8 N 306 8x52 s8s9 D 142 N.s8s9.06
Van-der-waals H8 N 306 8x52 s8s9 D 142 N.s8s9.06
Aromatic H8 Y 307 8x53 S16 Y 258 C.S16.02
Hydrophobic H8 Y 307 8x53 S16 Y 258 C.S16.02
Van-der-waals H8 Y 307 8x53 S16 Y 258 C.S16.02
Hydrophobic H8 F 308 8x54 S9 C 147 N.S9.01
Van-der-waals H8 F 308 8x54 S9 C 147 N.S9.01
Polar C-term F 320 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term F 320 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term F 320 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term F 320 - S18 L 328 C.S18.02
Van-der-waals C-term F 320 - S18 L 328 C.S18.02
Hydrophobic H8 F 308 8x54 s15s16 S 255 C.s15s16.04
Van-der-waals H8 F 308 8x54 s15s16 S 255 C.s15s16.04
Polar H8 T 304 8x50 S16 V 260 C.S16.04
Van-der-waals H8 T 304 8x50 S16 V 260 C.S16.04
Hydrophobic H8 Y 307 8x53 s15s16 S 255 C.s15s16.04
Van-der-waals H8 Y 307 8x53 s15s16 S 255 C.s15s16.04
Polar C-term R 316 - S16 Y 258 C.S16.02
Van-der-waals C-term R 316 - S16 Y 258 C.S16.02
Hydrophobic H8 T 304 8x50 S16 Y 259 C.S16.03
Van-der-waals H8 T 304 8x50 S16 Y 259 C.S16.03
Hydrophobic C-term R 328 - s10s11 P 190 C.s10s11.07
Van-der-waals C-term R 328 - s10s11 P 190 C.s10s11.07
Hydrophobic C-term D 339 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term D 339 - s11s12 F 201 C.s11s12.02
Aromatic C-term H 341 - s11s12 F 201 C.s11s12.02
Hydrophobic C-term H 341 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term H 341 - s11s12 F 201 C.s11s12.02
Polar H8 P 305 8x51 S16 Y 258 C.S16.02
Hydrophobic H8 P 305 8x51 S16 Y 258 C.S16.02
Van-der-waals H8 P 305 8x51 S16 Y 258 C.S16.02
Polar H8 T 304 8x50 S16 K 261 C.S16.05
Hydrophobic H8 T 304 8x50 S16 K 261 C.S16.05
Van-der-waals H8 T 304 8x50 S16 K 261 C.S16.05
Aromatic H8 F 308 8x54 S16 Y 259 C.S16.03
Hydrophobic H8 F 308 8x54 S16 Y 259 C.S16.03
Van-der-waals H8 F 308 8x54 S16 Y 259 C.S16.03
Polar C-term T 318 - S16 Y 258 C.S16.02
Hydrophobic C-term T 318 - S16 Y 258 C.S16.02
Van-der-waals C-term T 318 - S16 Y 258 C.S16.02
Polar H8 F 308 8x54 S16 D 257 C.S16.01
Hydrophobic H8 F 308 8x54 S16 D 257 C.S16.01
Van-der-waals H8 F 308 8x54 S16 D 257 C.S16.01
Hydrophobic H8 F 308 8x54 S15 V 251 C.S15.14
Ionic H8 D 309 8x55 s8s9 K 145 N.s8s9.09
Polar H8 D 309 8x55 s8s9 K 145 N.s8s9.09
Hydrophobic H8 D 309 8x55 s8s9 K 145 N.s8s9.09
Van-der-waals H8 D 309 8x55 s8s9 K 145 N.s8s9.09
Hydrophobic C-term F 320 - s17s18 T 314 C.s17s18.30
Hydrophobic C-term L 326 - s12s13 E 216 C.s12s13.03
Van-der-waals C-term L 326 - s12s13 E 216 C.s12s13.03
Hydrophobic H8 F 308 8x54 s8s9 K 145 N.s8s9.09
Van-der-waals H8 F 308 8x54 s8s9 K 145 N.s8s9.09
Polar H8 N 306 8x52 s8s9 K 145 N.s8s9.09
Hydrophobic H8 N 306 8x52 s8s9 K 145 N.s8s9.09
Van-der-waals H8 N 306 8x52 s8s9 K 145 N.s8s9.09
Polar C-term R 314 - s15s16 S 256 C.s15s16.05
Van-der-waals C-term R 314 - s15s16 S 256 C.s15s16.05
Hydrophobic C-term M 315 - s17s18 T 323 C.s17s18.39
Van-der-waals C-term M 315 - s17s18 T 323 C.s17s18.39
Hydrophobic C-term E 322 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term E 322 - s17s18 R 322 C.s17s18.38
Polar H8 E 302 8x48 S16 K 261 C.S16.05
Hydrophobic H8 L 300 8x46 S18 K 336 C.S18.10
Hydrophobic H8 N 306 8x52 S16 D 257 C.S16.01
Van-der-waals H8 N 306 8x52 S16 D 257 C.S16.01
Polar H8 N 306 8x52 S16 Y 259 C.S16.03